Detalhe da pesquisa
1.
Risankizumab as maintenance therapy for moderately to severely active Crohn's disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial.
Lancet
; 399(10340): 2031-2046, 2022 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35644155
2.
Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials.
Lancet
; 399(10340): 2015-2030, 2022 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35644154
3.
Mechanistic study of classical translocation-dead SpoIIIE36 reveals the functional importance of the hinge within the SpoIIIE motor.
J Bacteriol
; 196(13): 2481-90, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24769697
4.
SpoIIIE protein achieves directional DNA translocation through allosteric regulation of ATPase activity by an accessory domain.
J Biol Chem
; 288(40): 28962-74, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23974211
5.
Risankizumab: Mechanism of action, clinical and translational science.
Clin Transl Sci
; 17(1): e13706, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266061
6.
Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease Patients.
J Crohns Colitis
; 18(3): 431-445, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37776235
7.
Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn's disease.
J Crohns Colitis
; 2023 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37551994
8.
Baseline TREM-1 Whole Blood Gene Expression Does Not Predict Response to Adalimumab Treatment in Patients with Ulcerative Colitis or Crohn's Disease in the SERENE Studies.
J Crohns Colitis
; 2023 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37801628
9.
Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
BMC Struct Biol
; 12: 22, 2012 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22995073
10.
The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum.
J Biol Chem
; 285(27): 20732-9, 2010 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20435896
11.
Mechanisms and regulation of IL-22-mediated intestinal epithelial homeostasis and repair.
Life Sci
; 271: 119195, 2021 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33581125
12.
A population of proinflammatory T cells coexpresses αß and γδ T cell receptors in mice and humans.
J Exp Med
; 217(5)2020 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32106283