Detalhe da pesquisa
1.
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature
; 629(8011): 435-442, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38658751
2.
Formation of α-SF5-Enolate Enables Preparation of 3-SF5-Quinolin-2-ones, 3-SF5-Quinolines, and 3-SF5-Pyridin-2-ones: Evaluation of their Physicochemical Properties.
Angew Chem Int Ed Engl
; 55(6): 2113-7, 2016 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26732047
3.
Adventures in drug-like chemistry space: from oxetanes to spiroazetidines and beyond!
Chimia (Aarau)
; 68(7-8): 492-9, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25437389
4.
Small-Molecule Lead-Finding Trends across the Roche and Genentech Research Organizations.
J Med Chem
; 65(4): 3606-3615, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35138850
5.
Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes.
Bioorg Med Chem Lett
; 21(1): 191-4, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21134747
6.
Gene expression-based in vivo and in vitro prediction of liver toxicity allows compound selection at an early stage of drug development.
J Biochem Mol Toxicol
; 25(3): 183-94, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21671310
7.
Selective naphthalene H(3) receptor inverse agonists with reduced potential to induce phospholipidosis and their quinoline analogs.
Bioorg Med Chem Lett
; 19(15): 4495-500, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19524437
8.
Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.
Bioorg Med Chem Lett
; 19(9): 2595-8, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19328688
9.
Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.
J Med Chem
; 51(7): 2115-27, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18335976
10.
Stereoselective synthesis of methyl monate C.
Org Lett
; 8(26): 6111-4, 2006 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17165942
11.
Systematic investigation of halogen bonding in protein-ligand interactions.
Angew Chem Int Ed Engl
; 50(1): 314-8, 2011 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21184410
12.
Evaluation of tert-butyl isosteres: case studies of physicochemical and pharmacokinetic properties, efficacies, and activities.
ChemMedChem
; 10(3): 461-9, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25630804
13.
Synthesis and stability of oxetane analogs of thalidomide and lenalidomide.
Org Lett
; 15(17): 4312-5, 2013 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23937240
14.
The histamine H3 receptor as a therapeutic drug target for metabolic disorders: status, challenges and opportunities.
Curr Top Med Chem
; 11(12): 1430-46, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21510840
15.
Halogen bonding at the active sites of human cathepsinâ L and MEK1 kinase: efficient interactions in different environments.
ChemMedChem
; 6(11): 2048-54, 2011 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21898833
16.
5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.
J Med Chem
; 52(13): 3855-68, 2009 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19456097
17.
Aminothiazole derivatives as neuropeptide Y5 receptor ligands: finding the balance between affinity and physicochemical properties.
ChemMedChem
; 1(1): 45-8, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16892333