Detalhe da pesquisa
1.
First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors.
Bioorg Med Chem Lett
; 29(14): 1836-1841, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31104993
2.
The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA.
Apoptosis
; 19(1): 201-9, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24072590
3.
Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.
J Biol Chem
; 286(28): 24882-95, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21628457
4.
Nature of pharmacophore influences active site specificity of proteasome inhibitors.
J Biol Chem
; 285(51): 40125-34, 2010 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20937826
5.
Role of PLEXIND1/TGFß Signaling Axis in Pancreatic Ductal Adenocarcinoma Progression Correlates with the Mutational Status of KRAS.
Cancers (Basel)
; 13(16)2021 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34439202
6.
Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
Biosci Rep
; 38(4)2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29472314
7.
Highly efficient ruthenium catalysts for the formation of tetrasubstituted olefins via ring-closing metathesis.
Org Lett
; 9(8): 1589-92, 2007 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-17378575
8.
Inhibition of the Proteasome ß2 Site Sensitizes Triple-Negative Breast Cancer Cells to ß5 Inhibitors and Suppresses Nrf1 Activation.
Cell Chem Biol
; 24(2): 218-230, 2017 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28132893
9.
Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex.
Nat Chem Biol
; 5(3): 129-30; author reply 130, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19219009
10.
Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth.
Mol Cancer Ther
; 13(10): 2264-75, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25125675
11.
Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain.
Biosci Rep
; 38(4)2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29871975
12.
A small fluorophore reporter of protein conformation and redox state.
Chem Commun (Camb)
; 47(20): 5714-6, 2011 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21487611
13.
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells.
Sci Signal
; 4(179): rs5, 2011 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21712546
14.
Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib.
Chem Biol
; 18(5): 608-18, 2011 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21609842
15.
Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.
J Biol Chem
; 284(1): 158-164, 2009 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19001417
16.
Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.
Chem Biol
; 16(12): 1278-89, 2009 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20064438
17.
General synthesis of pyrroloquinolizidines: synthesis of an unnatural homologue of the pyrroloindolizidine myrmicarin alkaloid 215B.
J Org Chem
; 72(6): 2015-20, 2007 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17315932
18.
Carbopalladation of nitriles: synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of omega-(2-iodoaryl)alkanenitriles and related compounds.
J Org Chem
; 67(26): 9428-38, 2002 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12492349
19.
Carbopalladation of nitriles: synthesis of 3,4-disubstituted 2-aminonaphthalenes and 1,3-benzoxazine derivatives by the palladium-catalyzed annulation of alkynes by (2-Iodophenyl)acetonitrile.
J Org Chem
; 68(2): 339-47, 2003 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12530858
20.
Carbopalladation of nitriles: synthesis of 2,3-diarylindenones and polycyclic aromatic ketones by the Pd-catalyzed annulation of alkynes and bicyclic alkenes by 2-iodoarenenitriles.
J Org Chem
; 67(26): 9276-87, 2002 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12492329