Advanced Data Processing of Pancreatic Cancer Data Integrating Ontologies and Machine Learning Techniques to Create Holistic Health Records.

The modern healthcare landscape is overwhelmed by data derived from heterogeneous IoT data sources and Electronic Health Record (EHR) systems. Based on the advancements in data science and Machine Learning (ML), an improved ability to integrate and process the so-called primary and secondary data fosters the provision of real-time and personalized decisions. In that direction, an innovative mechanism for processing and integrating health-related data is introduced in this article. It describes the details of the mechanism and its internal subcomponents and workflows, together with the results from its utilization, validation, and evaluation in a real-world scenario. It also highlights the potential derived from the integration of primary and secondary data into Holistic Health Records (HHRs) and from the utilization of advanced ML-based and Semantic Web techniques to improve the quality, reliability, and interoperability of the examined data. The viability of this approach is evaluated through heterogeneous healthcare datasets pertaining to personalized risk identification and monitoring related to pancreatic cancer. The key outcomes and innovations of this mechanism are the introduction of the HHRs, which facilitate the capturing of all health determinants in a harmonized way, and a holistic data ingestion mechanism for advanced data processing and analysis.

Discovering Composite Lifestyle Biomarkers With Artificial Intelligence From Clinical Studies to Enable Smart eHealth and Digital Therapeutic Services.

Discovery of biomarkers is a continuous activity of the research community in the clinical domain that recently shifted its focus toward digital, non-traditional biomarkers that often use physiological, psychological, social, and environmental data to derive an intermediate biomarker. Such biomarkers, by triggering smart services, can be used in a clinical trial framework and eHealth or digital therapeutic services. In this work, we discuss the APACHE trial for determining the quality of life (QoL) of cervical cancer patients and demonstrate how we are discovering a biomarker for this therapeutic area that predicts significant QoL variations. To this extent, we present how real-world data can unfold a big potential for detecting the cervical cancer QoL biomarker and how it can be used for novel treatments. The presented methodology, derived in APACHE, is introduced by Healthentia eClinical solution, and it is beginning to be used in several clinical studies.

Audio-visual active speaker tracking in cluttered indoors environments.

We propose a system for detecting the active speaker in cluttered and reverberant environments where more than one person speaks and moves. Rather than using only audio information, the system utilizes audiovisual information from multiple acoustic and video sensors that feed separate audio and video tracking modules. The audio module operates using a particle filter (PF) and an information-theoretic framework to provide accurate acoustic source location under reverberant conditions. The video subsystem combines in 3-D a number of 2-D trackers based on a variation of Stauffer's adaptive background algorithm with spatiotemporal adaptation of the learning parameters and a Kalman tracker in a feedback configuration. Extensive experiments show that gains are to be expected when fusion of the separate modalities is performed to detect the active speaker.

Audio-visual active speaker tracking in cluttered indoors environments.

We propose a system for detecting the active speaker in cluttered and reverberant environments where more than one person speaks and moves. Rather than using only audio information, the system utilizes audiovisual information from multiple acoustic and video sensors that feed separate audio and video tracking modules. The audio module operates using a particle filter (PF) and an information-theoretic framework to provide accurate acoustic source location under reverberant conditions. The video subsystem combines in 3-D a number of 2-D trackers based on a variation of Stauffer's adaptive background algorithm with spatiotemporal adaptation of the learning parameters and a Kalman tracker in a feedback configuration. Extensive experiments show that gains are to be expected when fusion of the separate modalities is performed to detect the active speaker.