Detalhe da pesquisa
1.
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
EMBO J
; 39(21): e105111, 2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32945574
2.
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
Proc Natl Acad Sci U S A
; 116(36): 17990-18000, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31439820
3.
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Blood
; 129(21): 2882-2895, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283481
4.
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance.
Int J Cancer
; 142(10): 2139-2152, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29243224
5.
A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.
Genome Res
; 25(2): 201-12, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25452314
6.
Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth.
Nucleic Acids Res
; 44(16): 7646-58, 2016 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27207882
7.
Targeting the ribosome to treat multiple myeloma.
Mol Ther Oncol
; 32(1): 200771, 2024 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38596309
8.
c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation.
Nucleic Acids Res
; 39(8): 3267-81, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21177653
9.
Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation.
Blood
; 112(6): 2305-17, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18621930
10.
rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.
Front Cell Dev Biol
; 8: 568, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32719798
11.
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Nat Commun
; 11(1): 2641, 2020 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32457376
12.
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.
Commun Biol
; 2: 39, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30701204
13.
First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Cancer Discov
; 9(8): 1036-1049, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092402
14.
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.
Mol Cell Biol
; 23(23): 8862-77, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14612424
15.
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
PLoS Negl Trop Dis
; 11(3): e0005432, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28263991
16.
Genomic characterisation of Eµ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.
Nat Commun
; 8: 14581, 2017 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262675
17.
Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.
Cancer Discov
; 6(1): 59-70, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26490423
18.
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Oncotarget
; 7(31): 49800-49818, 2016 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27391441
19.
S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.
Cell Signal
; 27(10): 2045-53, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26215099
20.
Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.
Nat Commun
; 6: 7404, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26074141