RESUMO
Foregut duplication cysts (FDCs) are rare malformations arising along primitively derived alimentary tract. Head and neck cases comprise 0.3% of all FDCs with 60% occurring in the oral cavity. We present a case of neonatal airway obstruction secondary to a prenatally diagnosed massive lingual FDC. Definitive treatment requires surgical excision. Histologically, the cysts are lined gastric and respiratory epithelium. FDC should be a consideration in prenatally diagnosed masses affecting the oral cavity.
Assuntos
Obstrução das Vias Respiratórias/etiologia , Cistos/complicações , Doenças da Língua/complicações , Língua/diagnóstico por imagem , Obstrução das Vias Respiratórias/diagnóstico , Obstrução das Vias Respiratórias/cirurgia , Biópsia , Cistos/congênito , Cistos/diagnóstico , Humanos , Recém-Nascido , Imageamento por Ressonância Magnética , Masculino , Procedimentos Cirúrgicos Bucais/métodos , Língua/cirurgia , Doenças da Língua/congênito , Doenças da Língua/diagnóstico , UltrassonografiaRESUMO
Despite advances in chemotherapy and the BCG (Bacillus Calmette-Guérin) vaccine, tuberculosis remains a significant infectious disease. Although it can be cured, the therapy takes at least 6-9 months, and the laborious and lengthy treatment brings with it dangers of noncompliance, significant toxicity and drug resistance. The increasing emergence of drug resistance and the problem of mycobacterial persistence highlight the need to develop novel TB drugs that are active against drug resistant bacteria but, more importantly, kill persistent bacteria and shorten the length of treatment. Recent new and exciting developments in tuberculosis drug discovery show good promise of a possible revolution in the chemotherapy of tuberculosis.