Detalhe da pesquisa
1.
Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Bioorg Med Chem
; 100: 117618, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38309201
2.
Preclinical Characterization and In Vivo Efficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein.
Antimicrob Agents Chemother
; 59(10): 6539-50, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26259798
3.
Design and synthesis of spirocyclic compounds as HCV replication inhibitors by targeting viral NS4B protein.
Bioorg Med Chem Lett
; 24(10): 2288-94, 2014 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24731273
4.
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.
J Med Chem
; 62(7): 3254-3267, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30763090
5.
The role of TDP1 from budding yeast in the repair of DNA damage.
DNA Repair (Amst)
; 3(6): 593-601, 2004 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15135727
6.
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
J Med Chem
; 57(5): 1902-13, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23672667
7.
Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization.
ACS Med Chem Lett
; 3(7): 565-9, 2012 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900511
8.
Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.
Proc Natl Acad Sci U S A
; 99(23): 14970-5, 2002 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-12397185
9.
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.
J Biol Chem
; 277(30): 27162-8, 2002 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-12023295
10.
TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II.
J Biol Chem
; 279(53): 55618-25, 2004 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-15494395