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1.
Holist Nurs Pract ; 38(2): 67-72, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38363967

RESUMO

This innovative project was funded by the Health Resources and Services Administration (HRSA) Nursing Workforce Diversity (NWD) grant (2017), with a resultant increase in the diversity of the nursing workforce in the rural Pee Dee Region of South Carolina. The project provided resources to at-risk students (n = 100) and compared participants with a control group (n = 92). The project provided participants mentors, financial assistance, experiential learning, advising, and professional development. The project descriptively compared program outcome benchmarks between groups. The project's multifaceted approach was key to success, providing implications for other programs to increase diversity of the nursing workforce.


Assuntos
Estudantes , Humanos , South Carolina , Recursos Humanos
2.
Am J Physiol Regul Integr Comp Physiol ; 322(3): R204-R218, 2022 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-35043683

RESUMO

After Roux-en-Y gastric bypass (RYGB), rats consume less high-energy foods and fluids, though whether this reflects a concomitant change in palatability remains unclear. By measuring behavior during intraorally delivered liquid meals across days (1 water, 8 sucrose sessions), we showed that RYGB rats (RYGB, n = 8/sex) consumed less 1.0 M sucrose than their sham surgery counterparts (SHAM, n = 8 males, n = 11 females) but displayed similarly high levels of ingestive taste reactivity responses at the start of infusions. Relative to water, both groups increased intake of sucrose, and ingestive responses were dominated by tongue protrusions rather than mouth movements. Thus, RYGB animals still found sucrose palatable despite consuming less than the SHAM group. As the intraoral infusion progressed but before meal termination, aversive behavior remained low and both RYGB and SHAM animals showed fewer ingestive responses, predominantly mouth movements as opposed to tongue protrusions. This shift in responsiveness unrelated to surgical manipulation suggests negative alliesthesia, or a decreased palatability, as rats approach satiation. Notably, only in RYGB rats, across sessions, there was a striking emergence of aversive behavior immediately after the sucrose meal. Thus, although lower intake in RYGB rats seems independent of the hedonic taste properties of sucrose, taste reactivity behavior in these animals immediately after termination of a liquid meal appears to be influenced by postoral events and reflects a state of nimiety or excessive consumption. Measurement of taste reactivity behaviors during an intraorally delivered meal represents a promising way to make inferences about internal state in nonverbal preclinical models.


Assuntos
Derivação Gástrica , Refeições , Sacarose/metabolismo , Paladar/fisiologia , Animais , Comportamento Animal/fisiologia , Ingestão de Alimentos/fisiologia , Comportamento Alimentar/fisiologia , Feminino , Derivação Gástrica/métodos , Masculino , Ratos Sprague-Dawley , Sacarose/administração & dosagem
3.
J Nutr ; 152(11): 2319-2332, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36774099

RESUMO

BACKGROUND: Lack of robust research methodology for assessing ingestive behavior has impeded clarification of the mediators of food intake following gastric bypass (GBP) surgery. OBJECTIVES: To evaluate changes in directly measured 24-h energy intake (EI), energy density (ED) (primary outcomes), eating patterns, and food preferences (secondary outcomes) in patients and time-matched weight-stable comparator participants. METHODS: Patients [n = 31, 77% female, BMI (in kg/m2) 45.5 ± 1.3] and comparators (n = 32, 47% female, BMI 27.2 ± 0.8) were assessed for 36 h under fully residential conditions at baseline (1 mo presurgery) and at 3 and 12 mo postsurgery. Participants had ad libitum access to a personalized menu (n = 54 foods) based on a 6-macronutrient mix paradigm. Food preferences were assessed by the Leeds Food Preference Questionnaire. Body composition was measured by whole-body DXA. RESULTS: In the comparator group, there was an increase in relative fat intake at 3 mo postsurgery; otherwise, no changes were observed in food intake or body composition. At 12 mo postsurgery, patients lost 27.7 ± 1.6% of initial body weight (P < 0.001). The decline in EI at 3 mo postsurgery (-44% from baseline, P < 0.001) was followed by a partial rebound at 12 mo (-18% from baseline), but at both times, dietary ED and relative macronutrient intake remained constant. The decline in EI was due to eating the same foods as consumed presurgery and by decreasing the size (g, MJ), but not the number, of eating occasions. In patients, reduction in explicit liking at 3 mo (-11.56 ± 4.67, P = 0.007) and implicit wanting at 3 (-15.75 ± 7.76, P = 0.01) and 12 mo (-15.18 ± 6.52, P = 0.022) for sweet foods were not matched by reduced intake of these foods. Patients with the greatest reduction in ED postsurgery reduced both EI and preference for sweet foods. CONCLUSIONS: After GBP, patients continue to eat the same foods but in smaller amounts. These findings challenge prevailing views about the dynamics of food intake following GBP surgery. This trial was registered as clinicaltrials.gov as NCT03113305.


Assuntos
Derivação Gástrica , Humanos , Feminino , Masculino , Derivação Gástrica/métodos , Comportamento Alimentar , Ingestão de Alimentos , Ingestão de Energia , Dieta , Preferências Alimentares
4.
Eur J Nutr ; 60(4): 2203-2215, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33104865

RESUMO

PURPOSE: To determine the small intestinal concentration of endocannabinoids (ECs), N-acylethanolamines (NAEs) and their precursors N-acylphosphatidylethanolamines (NAPEs) in humans. To identify relationships between those concentrations and habitual diet composition as well as individual inflammatory status. METHODS: An observational study was performed involving 35 participants with an ileostomy (18W/17M, aged 18-70 years, BMI 17-40 kg/m2). Overnight fasting samples of ileal fluid and plasma were collected and ECs, NAEs and NAPEs concentrations were determined by LC-HRMS. Dietary data were estimated from self-reported 4-day food diaries. RESULTS: Regarding ECs, N-arachidonoylethanolamide (AEA) was not detected in ileal fluids while 2-arachidonoylglycerol (2-AG) was identified in samples from two participants with a maximum concentration of 129.3 µg/mL. In contrast, mean plasma concentration of AEA was 2.1 ± 0.06 ng/mL and 2-AG was 4.9 ± 1.05 ng/mL. NAEs concentrations were in the range 0.72-17.6 µg/mL in ileal fluids and 0.014-0.039 µg/mL in plasma. NAPEs concentrations were in the range 0.3-71.5 µg/mL in ileal fluids and 0.19-1.24 µg/mL in plasma being more abundant in participants with obesity than normal weight and overweight. Significant correlations between the concentrations of AEA, OEA and LEA in biological fluids with habitual energy or fat intakes were identified. Plasma PEA positively correlated with serum C-reactive protein. CONCLUSION: We quantified ECs, NAEs and NAPEs in the intestinal lumen. Fat and energy intake may influence plasma and intestinal concentrations of these compounds. The luminal concentrations reported would allow modulation of the homeostatic control of food intake via activation of GPR119 receptors located on the gastro-intestinal mucosa. CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE: NCT04143139; www.clinicaltrials.gov .


Assuntos
Dieta , Endocanabinoides , Etanolaminas , Humanos , Obesidade , Sobrepeso , Receptores Acoplados a Proteínas G
5.
Chem Senses ; 44(3): 155-163, 2019 03 11.
Artigo em Inglês | MEDLINE | ID: mdl-30517609

RESUMO

This article provides a summary of the topics discussed at the symposium titled "Bariatric Surgery and Its Effects on Taste and Food Selection," which was held at the Fortieth Annual Meeting of the Association for Chemoreception Sciences. Bariatric surgery such as Roux-en-Y gastric bypass (RYGB) is currently one of the most effective treatments available for weight loss and Type 2 diabetes. For this reason, it is of great interest to clinicians as well as to basic scientists studying the controls of feeding and energy balance. Despite the commonly held view by clinicians that RYGB patients change their food preferences away from fats and sugars in favor of less energy dense alternatives such as vegetables, the empirical support for this claim is equivocal. It is currently thought that the taste and palatability of fats and sugars are affected by the surgery. Some key preclinical and clinical findings addressing these issues were evaluated in this symposium.


Assuntos
Cirurgia Bariátrica , Preferências Alimentares , Paladar , Humanos
6.
Nurs Educ Perspect ; 40(6): E25-E27, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644461

RESUMO

This funded project assisted veteran students to obtain a baccalaureate in nursing by aligning the skills learned through military training with concepts and skills valued by professional nursing and taught to nursing students. Nine concepts or skills were identified by nursing faculty that validated for course credit. The identified concepts and skills were incorporated into four simulation scenarios. Veteran students' skills were validated through simulation experiences in place of taking a three-credit nursing course. Anecdotal data from the debriefing process were rich with students' experiences and gratitude for being recognized for their military knowledge and service.


Assuntos
Bacharelado em Enfermagem/organização & administração , Inovação Organizacional , Estudantes de Enfermagem , Veteranos , Docentes de Enfermagem , Humanos
7.
Holist Nurs Pract ; 30(4): 211-5, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27223618

RESUMO

The current job market for nurses is variable and although there remains a projected shortage of nurses for the future, availability of entry-level positions has changed. This mixed-methods pilot study describes the successful use of simulated role-play to prepare senior nursing students (N = 66) for competitive job markets. The simulation laboratory was set up as a human resource department. The students and interviewers were evaluated by surveys. The majority of students rated the experience high for understanding interviews and assisting them with readiness for interviews. Qualitative results revealed themes of nervousness, confidence, and readiness. Interviewers also discussed student nervousness and the benefits of simulated interviews. These results affirmed that the overall learning outcome of the experience was positive and can assist in promoting professional role transition. The project will continue to be implemented, and it will be extended to graduate students in the future.


Assuntos
Bacharelado em Enfermagem/métodos , Modelos Educacionais , Estudantes de Enfermagem/estatística & dados numéricos , Humanos , Papel do Profissional de Enfermagem , Projetos Piloto
8.
Br J Nutr ; 113(3): 445-53, 2015 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-25585164

RESUMO

The bran and particularly the aleurone fraction of wheat are high in betaine and other physiological methyl donors, which may exert beneficial physiological effects. We conducted two randomised, controlled, cross-over postprandial studies to assess and compare plasma betaine and other methyl donor-related responses following the consumption of minimally processed bran and aleurone fractions (study A) and aleurone bread (study B). For both studies, standard pharmacokinetic parameters were derived for betaine, choline, folate, dimethylglycine (DMG), total homocysteine and methionine from plasma samples taken at 0, 0·5, 1, 2 and 3 h. In study A (n 14), plasma betaine concentrations were significantly and substantially elevated from 0·5 to 3 h following the consumption of both bran and aleurone compared with the control; however, aleurone gave significantly higher responses than bran. Small, but significant, increases were also observed in DMG measures; however, no significant responses were observed in other analytes. In study B (n 13), plasma betaine concentrations were significantly and substantially higher following consumption of the aleurone bread compared with the control bread; small, but significant, increases were also observed in DMG and folate measures in response to consumption of the aleurone bread; however, no significant responses were observed in other analytes. Peak plasma betaine concentrations, which were 1·7-1·8 times the baseline levels, were attained earlier following the consumption of minimally processed aleurone compared with the aleurone bread (time taken to reach peak concentration 1·2 v. 2·1 h). These results showed that the consumption of minimally processed wheat bran, and particularly the aleurone fraction, yielded substantial postprandial increases in plasma betaine concentrations. Furthermore, these effects appear to be maintained when aleurone was incorporated into bread.


Assuntos
Betaína/sangue , Pão , Fibras na Dieta/administração & dosagem , Período Pós-Prandial , Sementes , Triticum , Adulto , Betaína/análise , Betaína/farmacocinética , Colina/análise , Colina/sangue , Estudos Cross-Over , Feminino , Ácido Fólico/análise , Ácido Fólico/sangue , Manipulação de Alimentos , Humanos , Masculino , Sarcosina/análogos & derivados , Sarcosina/sangue , Sementes/química , Triticum/química
9.
Public Health Nutr ; 18(1): 100-11, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25100625

RESUMO

OBJECTIVE: To (i) explore the factors influencing family out-of-home (OH) eating events and (ii) identify possible opportunities for food businesses to support families in making healthier OH choices. DESIGN: Focus group discussions were conducted with parents (six to eight participants per group) and friendship pair discussions (informal interviews with two children who are friends) were conducted with children (5-12 years) throughout the island of Ireland. Both discussions were audio-recorded and analysed using a thematic content analysis. SETTING: Eight focus groups and sixteen friendship pairs were conducted in Northern Ireland and sixteen focus groups and thirty-two friendship pairs were conducted in the Republic of Ireland. SUBJECTS: Purposive sampling was used to recruit a sample of non-related parents and children that represented equal numbers of gender, age, socio-economic status and demographic backgrounds. RESULTS: The main, overarching theme was that families perceived OH eating to be a treat, while health was not currently a key priority for many parents and children. Children were reported to have most responsibility for their own food choice decisions in this environment, with taste and food neophobia having the greatest influences. Parents believed that if food businesses could meet parent and child priorities in addition to health influences, e.g. change cooking methods, and increase flexibility, then families would be more likely to patronise these establishments. CONCLUSIONS: The entire family OH eating experience needs to be considered when developing public health interventions and this research has highlighted key opportunities that caterers could employ to support healthier family OH food choices.


Assuntos
Fenômenos Fisiológicos da Nutrição Infantil , Saúde da Família , Refeições , Política Nutricional , Pais , Cooperação do Paciente , Restaurantes , Criança , Fenômenos Fisiológicos da Nutrição Infantil/etnologia , Pré-Escolar , Saúde da Família/etnologia , Feminino , Grupos Focais , Preferências Alimentares/etnologia , Amigos , Humanos , Irlanda , Masculino , Refeições/etnologia , Irlanda do Norte , Poder Familiar/etnologia , Cooperação do Paciente/etnologia , Pesquisa Qualitativa
10.
J Perinat Neonatal Nurs ; 28(4): 300-4, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25347108

RESUMO

To evaluate differences in feeding tolerance between infants maintained on continuous positive airway pressure (CPAP) and those receiving high-flow (nasal) cannula (HFC) with or without CPAP. This is a retrospective, cross-sectional study. Two groups of very low-birth-weight infants (750-1500 g) were compared on the basis of respiratory support: (1) infants born between the January 2002 and December 2004 treated with CPAP; and (2) infants born between January 2005 and December 2006 treated with HFC with or without CPAP. The groups were compared to determine which of the two attained full feedings sooner. Successful achievement of full feedings was measured in days from birth and defined by discontinuation of hyperalimentation-supplementation and attainment of 120 mL/kg/d of enteral feedings. A total of 185 infants met inclusion criteria (103 who received CPAP exclusively and 82 who received HFC with or without CPAP). There was no statistical difference in time to full enteral feedings between the 2 groups. There was also no difference in time of initiation of oral feeding or days to full oral feedings between 2 groups. The use of HFC was not associated with changes in feeding tolerance in premature infants. Further studies are needed to investigate efficacy and potential advantages and disadvantages to the use of HFC in the very low-birth-weight infant population.


Assuntos
Pressão Positiva Contínua nas Vias Aéreas/métodos , Nutrição Enteral , Recém-Nascido Prematuro , Recém-Nascido de muito Baixo Peso/fisiologia , Nutrição Parenteral Total , Estudos Transversais , Nutrição Enteral/efeitos adversos , Nutrição Enteral/métodos , Feminino , Humanos , Recém-Nascido , Tempo de Internação , Masculino , Nutrição Parenteral Total/efeitos adversos , Nutrição Parenteral Total/métodos , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento , Aumento de Peso
11.
J Nurs Meas ; 22(3): 361-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25608425

RESUMO

BACKGROUND AND PURPOSE: The original Emancipated Decision-Making (EDM) scale was revised to test 3 subconcepts (flexible environment, personal knowledge, and awareness of social norms) of an emancipated decision-making process. METHODS: The original EDM scale was significantly related to the Satisfaction with Decision (SWD) scale in two separate studies (r = 0.79, r = 0.59). Two of the original 5 subconcepts showed a lack of contribution. The third study (N = 50) had good total scale reliability (r = 0.89). RESULTS: The revised EDM (EDM-r) scale was then leveled to the SWD scores and quantified into 2 categories and the subscales for the 3 subconcepts were reanalyzed for reliability and scale-if-item contribution. CONCLUSION: The final EDM-r is a generically worded, 20-item, 3-subscale instrument with good total and individual subscale reliability.


Assuntos
Tomada de Decisões , Conhecimentos, Atitudes e Prática em Saúde , Poder Psicológico , Saúde da Mulher , Adulto , Feminino , Humanos , Modelos Teóricos , Projetos Piloto , Desenvolvimento de Programas , Reprodutibilidade dos Testes , Normas Sociais , Valores Sociais
12.
Brain Stimul ; 17(4): 782-793, 2024 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-38797370

RESUMO

BACKGROUND: Insomnia is a prevalent health concern in the general population associated with a range of adverse health effects. New, effective, safe and low-cost treatments, suitable for long-term use, are urgently required. Previous studies have shown the potential of electrical vestibular nerve stimulation (VeNS) in improving insomnia symptoms, however only one sham-controlled trial has been conducted on people with chronic insomnia. OBJECTIVES: /Hypothesis: Repeated VeNS delivered by the Modius Sleep device prior to sleep onset will show superior improvement in Insomnia Severity Index (ISI) scores over a 4-week period compared to sham stimulation. METHODS: In this double-blinded, multi-site, randomised, sham-controlled study, 147 participants with moderate to severe insomnia (ISI≥15) were recruited and allocated a VeNS or a sham device (1:1 ratio) which they were asked to use at home for 30 min daily (minimum 5 days per week) for 4 weeks. RESULTS: After 4 weeks, mean ISI score reduction was 2.26 greater in the VeNS treatment group than the sham group (p = 0.002). In the per protocol analysis, the treatment group had a mean ISI score decrease of 5.8 (95 % CI [-6.8, -4.81], approaching the clinically meaningful threshold of a 6-point reduction, with over half achieving a clinically significant decrease. Furthermore, the treatment group showed superior improvement to the sham group in the SF-36 (Quality of Life) energy/fatigue component (PP p = 0.004, effect size 0.26; ITT p = 0.006, effect size 0.22). CONCLUSIONS: Modius sleep has the potential to provide a viable, non-invasive and safe clinically meaningful alternative treatment option for insomnia.

13.
J Adv Nurs ; 69(11): 2470-80, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23488910

RESUMO

AIM: To increase understanding of women's decision-making process concerning the medication use for anxiety and/or depression while pregnant. BACKGROUND: Anxiety and depression affects many pregnant women, yet the decision to take psychotropic medication is complex and possibly subject to social oppression. DESIGN: Cross-sectional descriptive survey design. METHODS: A web-based survey was used to collect data from a convenience sample of 143 pregnant women over 3 months beginning in early 2011. An independent t-test was conducted to determine differences in satisfaction between women with high and low levels of emancipated decision-making (EDM). A multiple regression analysis was conducted to determine which subscales of the emancipation scale best predict level of satisfaction with the decision. FINDINGS: The majority of respondents were White, between 25-34 years of age. The group with lower levels of emancipation reported lower mean satisfaction scores compared with those with higher levels of emancipation. Regression analysis showed that the three subscale emancipation model was a statistically significant predictor of satisfaction with the decision and accounted for 54% of the variance in satisfaction. The subconcept of personal knowledge was most predictive of satisfaction with decision. CONCLUSIONS: Women may be able to overcome oppressive forces by using an EDM process. EDM allows them to make a decision that feels right for them and to feel satisfied with the decision.


Assuntos
Transtornos de Ansiedade/tratamento farmacológico , Tomada de Decisões , Transtorno Depressivo/tratamento farmacológico , Complicações na Gravidez/psicologia , Psicotrópicos/administração & dosagem , Adolescente , Adulto , Estudos Transversais , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Pessoa de Meia-Idade , Satisfação do Paciente , Gravidez , Inquéritos e Questionários , Adulto Jovem
14.
BMJ Open Qual ; 12(2)2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-37068854

RESUMO

BACKGROUND: Medicines optimisation and adherence support are essential to secondary prevention after myocardial infarction (MI). Following successful implementation of a consultant pharmacist-led post-MI medicines optimisation clinic, the service was expanded by training advanced clinical pharmacists to manage clinics (with appropriate multidisciplinary team support). METHODS: Key steps in the development process were: definition of a key competency framework based on relevant qualifications and experience, knowledge, skills and clinic management practicalities; creation and enaction of trainee-specific development plans to address gaps (including independent learning, teaching from multidisciplinary colleagues and shadowing in clinics); establishment of relevant protocols and proformas to ensure consistent standards (eg, a patient self-reporting tool for identifying adherence barriers, consultation proforma, directory of clinical parameters and pathway for onward referral when needed); phased clinic roll-out, initially under supervision; and gathering of feedback from patients and colleagues. Clinic letters from 50 attending patients were reviewed to quantify resulting interventions; the first 50 anonymously completed patient feedback questionnaires were also analysed. RESULTS: Expansion of the service initially doubled capacity. A review of clinic letters from attending patients demonstrated that various interventions were recommended, including further investigations, medication changes, lifestyle adjustments and onward referrals. Most respondents to the patient feedback questionnaire thought the clinic was patient friendly and welcoming (n=48/50; 96%); felt listened to (n=48/50; 96%); considered that adequate explanation was given (n=47/50; 94%); and felt clear plans were provided (n=45/49; 92%). Most agreed that it was valuable (n=44/50; 88%), and the mean rating was 4.48 (on a scale of 1 (very poor) to 5 (excellent)). CONCLUSIONS: A person-centred post-MI medicines optimisation service was successfully delivered by appropriately trained advanced cardiology pharmacists. A structured competency framework and training programme were required, but once completed, the clinic was highly valued by patients. A similar model could be rolled out elsewhere with adaption to local requirements.


Assuntos
Infarto do Miocárdio , Farmacêuticos , Humanos , Retroalimentação , Inquéritos e Questionários , Autorrelato , Infarto do Miocárdio/tratamento farmacológico
15.
Food Res Int ; 165: 112472, 2023 03.
Artigo em Inglês | MEDLINE | ID: mdl-36869485

RESUMO

Chloroplasts are abundant organelles in a diverse range of plant materials; they are predominantly composed of multicomponent thylakoid membranes which are lipid and protein rich. Intact or unravelled thylakoid membranes should, in principle, have interfacial activity, but little has been published on their activity in oil-in-water systems, and nothing on their performance on an oil continuous system. In this work different physical methods were used to produce a range of chloroplast/thylakoid suspensions with varying degrees of membrane integrity. Transmission electron microscopy revealed that pressure homogenisation led to the greatest extent of membrane and organelle disruption compared to less energy intensive preparation methods The ability of the derived materials to modulate the flow behaviour of a chocolate model system (65% (w/w) sugar/ sunflower oil (natural amphiphiles removed) suspension) was investigated by acquiring rheological parameters. All chloroplast/thylakoid preparations reduced yield stress, apparent viscosity, tangent flow point and cross over point in a concentration-dependent fashion, although not as significantly as polyglycerol polyricinoleate applied at a commercially relevant concentration in the same chocolate model system. Confocal laser scanning microscopy confirmed presence of the alternative flow enhancer material at the sugar surfaces. This research reveals that low-energy processing methods that do not extensively disrupt thylakoid membranes are applicable to generating materials with marked capacity to affect the flow behaviour of a chocolate model system. In conclusion, chloroplast/thylakoid materials hold strong potential as natural alternatives to synthetic rheology modifiers for lipid-based systems such as PGPR.


Assuntos
Cacau , Tilacoides , Cloroplastos , Ácidos Ricinoleicos , Açúcares
16.
PLoS One ; 18(8): e0289911, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37624789

RESUMO

BACKGROUND AND AIM: Attempts at personalisation of exercise programmes in head and neck cancer (HaNC) have been limited. The main aim of the present study is to investigate the feasibility and acceptability of introducing a remotely delivered, fully personalised, collaborative, and flexible approach to prescribing and delivering exercise programmes into the HaNC usual care pathway. METHODS: This is a single arm, feasibility study. Seventy patients diagnosed with HaNC will be recruited from two regional HaNC centres in the United Kingdom. Patients will undertake an 8-week exercise programme designed and delivered by cancer exercise specialists. The exercise programme will start any time between the time of diagnosis and up to 8 weeks after completing treatment, depending on patient preference. The content of the exercise programme will be primarily based on patient needs, preferences, and goals, but guided by current physical activity guidelines for people with cancer. The primary outcome measure is retention to the study. Secondary quantitative outcomes are uptake to the exercise programme, different measures of exercise adherence, pre- and post-intervention assessments of fatigue (Multidimensional Fatigue Symptom Inventory-Short Form), quality of life (SF-36), physical activity levels (International Physical Activity Questionnaire-Short Form), and various components of physical fitness. The outcomes of the nested qualitative study are acceptability and feasibility of the intervention evaluated via interviews with patients, health care professionals, and the cancer exercise specialists. Intervention and participant fidelity will be determined using checklists and scrutiny of each patient's logbook and the cancer exercise specialists' meeting notes. Analysis of quantitative data will be via standard summary statistics. Qualitative data will be analysed using thematic analysis. EXPECTED RESULTS: This feasibility study will inform the design and conduct of a future randomised controlled trial. Success will be defined according to a traffic light system for identifying the appropriateness of progression to a randomised controlled trial. TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number registry (ISRCTN82505455).


Assuntos
Neoplasias de Cabeça e Pescoço , Qualidade de Vida , Humanos , Estudos de Viabilidade , Neoplasias de Cabeça e Pescoço/terapia , Exercício Físico , Fadiga , Ensaios Clínicos Controlados Aleatórios como Assunto
17.
Crit Rev Food Sci Nutr ; 52(6): 553-68, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22452734

RESUMO

Over the last three decades substantial attention has been given to the role of dietary fiber in health and disease, in particular diabetes, cardiovascular disease, intestinal health, and some types of cancer. As a result the food industry started to add back fiber to refined foods and develop fiber rich foods. Scientists suggested that whole grain foods are superior to foods enriched with fibers obtained/synthesized using enzyme treatment, and thermal or chemical processing because the content of bioactive components and micronutrients in whole grain is more abundant. This triggered interest in how to isolate the micronutrient rich aleurone fiber fraction from wheat. Aleurone is a single cell layer at the inner site of the bran. It contains most of the minerals, vitamins, phenolic antioxidants, and lignans of the wheat grain. Novel milling and dry-fractionation techniques have recently allowed for full-scale separation of aleurone cells from the other layers of wheat bran, yielding a fiber rich concentrate which potentially contains many of the "whole grain kernel bioactives," which recently have been used in a variety of studies. The present review highlights available data on aleurone isolation, composition, intestinal physiology, and its metabolism and potential health benefits as well as its use in food.


Assuntos
Fibras na Dieta , Manipulação de Alimentos , Triticum/química , Aditivos Alimentares , Humanos , Micronutrientes
18.
Br J Nutr ; 108(9): 1644-51, 2012 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-22243564

RESUMO

Observational data show an inverse association between the consumption of whole-grain foods, and inflammation and related diseases. Although the underlying mechanisms are unclear, whole grains, and in particular the aleurone layer, contain a wide range of components with putative antioxidant and anti-inflammatory effects. We evaluated the effects of a diet high in wheat aleurone on plasma antioxidants status, markers of inflammation and endothelial function. In this parallel, participant-blinded intervention, seventy-nine healthy, older, overweight participants (45-65 years, BMI>25 kg/m²) incorporated either aleurone-rich cereal products (27 g aleurone/d), or control products balanced for fibre and macronutrients, into their habitual diets for 4 weeks. Fasting blood samples were taken at baseline and on day 29. Results showed that, compared to control, consumption of aleurone-rich products provided substantial amounts of micronutrients and phytochemicals which may function as antioxidants. Additionally, incorporating these products into a habitual diet resulted in significantly lower plasma concentrations of the inflammatory marker, C-reactive protein (P = 0·035), which is an independent risk factor for CVD. However, no changes were observed in other markers of inflammation, antioxidant status or endothelial function. These results provide a possible mechanism underlying the beneficial effects of longer-term whole-grain intake. However, it is unclear whether this effect is owing to a specific component, or a combination of components in wheat aleurone.


Assuntos
Envelhecimento/imunologia , Antioxidantes/análise , Endosperma/química , Endotélio Vascular/imunologia , Alimentos Fortificados , Sobrepeso/imunologia , Triticum/química , Idoso , Envelhecimento/sangue , Envelhecimento/fisiologia , Antioxidantes/administração & dosagem , Biomarcadores/sangue , Índice de Massa Corporal , Proteína C-Reativa/análise , Fibras na Dieta/administração & dosagem , Proteínas Alimentares/administração & dosagem , Endotélio Vascular/fisiologia , Endotélio Vascular/fisiopatologia , Feminino , Humanos , Masculino , Micronutrientes/administração & dosagem , Micronutrientes/sangue , Pessoa de Meia-Idade , Sobrepeso/sangue , Sobrepeso/fisiopatologia , Proteínas de Armazenamento de Sementes/administração & dosagem , Método Simples-Cego
19.
J Clin Nurs ; 21(17-18): 2545-54, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22564117

RESUMO

AIM AND OBJECTIVE: The objective of this literature review is to discuss human olfactory development, function and assessment through the lifespan. This article will highlight the importance of accurate olfactory function assessment. BACKGROUND: Olfactory function in humans is an understudied sense and may contribute significantly to patient safety and quality of life. Studies related to olfactory function are presented for different life stages. Olfactory development is reviewed as is terminology used to describe functionality. This article highlights the need for nursing assessment of olfactory function to develop holistic nursing interventions since there are implications for patient safety, quality of life issues related to respiratory function, bonding and nutrition. DESIGN: Literature review. METHOD: Articles were searched in CINAHL, PsychInfo and PubMed limited to those published in English to 2010 with the key terms 'olfactory and nursing'. The search yielded 47 articles that were clinically based on patient care. Those articles that dealt specifically with traumatic brain syndrome were excluded. However, peer reviewed and research article were both specified. RESULTS: There is evidence that olfactory assessment should be completed by nurses on high risk populations to ensure patent safety and enhance quality of life. CONCLUSIONS: More studies are needed to improve clinical knowledge about the role of olfactory function. RELEVANCE TO CLINICAL PRACTICE: Nurses are in a prime position to assess olfactory function for patients at high risk for deficits to provide holistic nursing care.


Assuntos
Avaliação em Enfermagem , Olfato , Saúde Holística , Humanos , Qualidade de Vida
20.
J Nurs Educ ; 51(11): 642-6, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22978275

RESUMO

Research indicates that having electronic resources readily available increases learners' ability to make clinical decisions and confidence in patient care. This mixed-method, descriptive pilot study collected data about senior prelicensure nursing students using smartphones, a type of mobile electronic device (MED), in the clinical area. The smartphones contained nursing diagnosis, pharmacology, and laboratory information; an encyclopedia; and the MEDLINE database. Student (n = 7) data about smartphone use during a 10-week clinical rotation were collected via student-recorded usage logs and focus group recordings. Staff nurses' (n = 5) perceptions of students' use of smartphones for clinical educational resources were collected by anonymous survey. Both the focus group transcript and staff surveys were evaluated and the themes summarized by content analysis. Positive results and barriers to use, such as cost and technological comfort levels, are discussed. The results may help nurse educators and administrators initiate further research of MEDs as a clinical resource.


Assuntos
Telefone Celular , Bacharelado em Enfermagem/métodos , Informática em Enfermagem/métodos , Recursos Humanos de Enfermagem/psicologia , Estudantes de Enfermagem/psicologia , Adulto , Atitude Frente aos Computadores , Computadores de Mão , Coleta de Dados , Feminino , Grupos Focais , Humanos , Masculino , Pesquisa em Avaliação de Enfermagem , Projetos Piloto
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