Detalhe da pesquisa
1.
Pharmacokinetic Profile of Brepocitinib with Topical Administration in Atopic Dermatitis and Psoriasis Populations: Strategy to Inform Clinical Trial Design in Adult and Pediatric Populations.
Pharm Res
; 41(4): 623-636, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38519816
2.
Evaluation of the effect of ritlecitinib on the pharmacokinetics of caffeine in healthy participants.
Br J Clin Pharmacol
; 89(7): 2208-2215, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36808638
3.
Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity.
Pharm Res
; 40(11): 2639-2651, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37561322
4.
Crisaborole and atopic dermatitis skin biomarkers: An intrapatient randomized trial.
J Allergy Clin Immunol
; 144(5): 1274-1289, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31419544
5.
A phase 2 study of filibuvir in combination with pegylated IFN alfa and ribavirin for chronic HCV.
Ann Hepatol
; 13(4): 364-75, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24927607
6.
Moving Beyond Boundaries: Utilization of Longitudinal Exposure-Response Model for Bounded Outcome Score to Inform Decision Making in the Accelerated Drug Development Paradigm.
Clin Pharmacokinet
; 63(3): 381-394, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38358645
7.
Antiviral activity of the hepatitis C virus polymerase inhibitor filibuvir in genotype 1-infected patients.
Hepatology
; 54(1): 50-9, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21488067
8.
Population PK and PD Analysis of Domagrozumab in Pediatric Patients with Duchenne Muscular Dystrophy.
Clin Pharmacol Ther
; 112(6): 1291-1302, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36104012
9.
Phase 1 study of crisaborole in Japanese healthy volunteers and patients with atopic dermatitis.
J Dermatol
; 47(1): 25-32, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31657024
10.
Randomized phase 2 trial and open-label extension of domagrozumab in Duchenne muscular dystrophy.
Neuromuscul Disord
; 30(6): 492-502, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32522498
11.
IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments.
Clin Immunol
; 132(1): 71-82, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19395317
12.
Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning.
J Clin Pharmacol
; 59(6): 811-820, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30556911
13.
Phosphatidylserine containing liposomes reduce immunogenicity of recombinant human factor VIII (rFVIII) in a murine model of hemophilia A.
J Pharm Sci
; 97(4): 1386-98, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17705286
14.
FDA Public Meeting Report on "Drug Interactions With Hormonal Contraceptives: Public Health and Drug Development Implications".
J Clin Pharmacol
; 58(12): 1655-1665, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30144093
15.
Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice.
J Pharm Sci
; 95(2): 358-71, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16372314
16.
Industrial Perspective on the Benefits Realized From the FDA's Model-Informed Drug Development Paired Meeting Pilot Program.
Clin Pharmacol Ther
; 110(5): 1172-1175, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991429
17.
Corrigendum to "Randomized phase 2 trial and open-label extension of domagrozumab in Duchenne muscular dystrophy" [Neuromuscular Disorders, Vol. 30 (6) 2020, 492-502].
Neuromuscul Disord
; 31(2): 167-168, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33451933
18.
Topology of factor VIII bound to phosphatidylserine-containing model membranes.
Biochim Biophys Acta
; 1617(1-2): 31-8, 2003 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-14637017
19.
Lipid binding region (2303-2332) is involved in aggregation of recombinant human FVIII (rFVIII).
J Pharm Sci
; 94(6): 1288-99, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15858858
20.
Intravenous administration of Factor VIII-O-Phospho-L-Serine (OPLS) complex reduces immunogenicity and preserves pharmacokinetics of the therapeutic protein.
Eur J Pharm Sci
; 66: 157-62, 2015 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25459532