Detalhe da pesquisa
1.
Increasing Linker Chain Length and Intestinal Stability Enhances Lymphatic Transport and Lymph Node Exposure of Triglyceride Mimetic Prodrugs of a Model Immunomodulator Mycophenolic Acid.
Mol Pharm
; 20(5): 2675-2685, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36996486
2.
A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.
J Biol Chem
; 296: 100345, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33515548
3.
Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles.
Pharm Res
; 38(9): 1497-1518, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34463935
4.
Lymphatic Transport and Lymphocyte Targeting of a Triglyceride Mimetic Prodrug Is Enhanced in a Large Animal Model: Studies in Greyhound Dogs.
Mol Pharm
; 13(10): 3351-3361, 2016 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27608166
5.
Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability.
Angew Chem Int Ed Engl
; 55(44): 13700-13705, 2016 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27482655
6.
Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug.
Pharm Res
; 32(5): 1830-44, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25446770
7.
Galanin-3 receptor antagonism by SNAP 37889 reduces motivation to self-administer alcohol and attenuates cue-induced reinstatement of alcohol-seeking in iP rats.
J Pharmacol Sci
; 125(2): 211-6, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24881957
8.
Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation.
Mol Pharm
; 10(5): 1874-89, 2013 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23480483
9.
Total synthesis of the proposed structure of 8-deshydroxyajudazol A: a modified approach to 2,4-disubstituted oxazoles.
J Org Chem
; 78(1): 116-23, 2013 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23126596
10.
Corrigendum: Triglyceride-mimetic prodrugs of buprenorphine enhance oral bioavailability via promotion of lymphatic transport.
Front Pharmacol
; 13: 1014363, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36133812
11.
Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport.
Front Pharmacol
; 13: 879660, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35496278
12.
Copper(I)-catalyzed cycloaddition of silver acetylides and azides: incorporation of volatile acetylenes into the triazole core.
Org Biomol Chem
; 9(17): 6082-8, 2011 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21748192
13.
The Impact of Conjugation Position and Linker Chemistry on the Lymphatic Transport of a Series of Glyceride and Phospholipid Mimetic Prodrugs.
J Pharm Sci
; 110(1): 489-499, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33069711
14.
Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice.
J Control Release
; 332: 636-651, 2021 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33609620
15.
Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity.
Nat Metab
; 3(9): 1175-1188, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34545251
16.
Total synthesis of enigmazole A from Cinachyrella enigmatica. Bidirectional bond constructions with an ambident 2,4-disubstituted oxazole synthon.
J Am Chem Soc
; 132(30): 10286-92, 2010 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20590095
17.
Oxazoline-oxazinone oxidative rearrangement. divergent syntheses of (2S,3S)-4,4,4-trifluorovaline and (2S,4S)-5,5,5-Trifluoroleucine.
J Org Chem
; 74(15): 5510-5, 2009 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19537688
18.
Amplification of the Cotton effect of a single chromophore through liposomal ordering-stereochemical assignment of plakinic acids I and J.
Angew Chem Int Ed Engl
; 48(24): 4367-71, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19437515
19.
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.
Sci Transl Med
; 9(392)2017 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28566424
20.
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.
Nat Commun
; 8(1): 69, 2017 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28701733