Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.

Ulges, Alexander; Klein, Matthias; Reuter, Sebastian; Gerlitzki, Bastian; Hoffmann, Markus; Grebe, Nadine; Staudt, Valérie; Stergiou, Natascha; Bohn, Toszka; Brühl, Till-Julius; Muth, Sabine; Yurugi, Hajime; Rajalingam, Krishnaraj; Bellinghausen, Iris; Tuettenberg, Andrea; Hahn, Susanne; Reißig, Sonja; Haben, Irma; Zipp, Frauke; Waisman, Ari; Probst, Hans-Christian; Beilhack, Andreas; Buchou, Thierry; Filhol-Cochet, Odile; Boldyreff, Brigitte; Breloer, Minka; Jonuleit, Helmut; Schild, Hansjörg; Schmitt, Edgar; Bopp, Tobias.

Nat Immunol ; 16(3): 267-75, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-25599562

2.

SnapShot: Expanding the Ubiquitin Code.

Rajalingam, Krishnaraj; Dikic, Ivan.

Cell ; 164(5): 1074-1074.e1, 2016 Feb 25.

Artigo em Inglês | MEDLINE | ID: mdl-26919436

3.

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.

Shin, Donghyuk; Mukherjee, Rukmini; Grewe, Diana; Bojkova, Denisa; Baek, Kheewoong; Bhattacharya, Anshu; Schulz, Laura; Widera, Marek; Mehdipour, Ahmad Reza; Tascher, Georg; Geurink, Paul P; Wilhelm, Alexander; van der Heden van Noort, Gerbrand J; Ovaa, Huib; Müller, Stefan; Knobeloch, Klaus-Peter; Rajalingam, Krishnaraj; Schulman, Brenda A; Cinatl, Jindrich; Hummer, Gerhard; Ciesek, Sandra; Dikic, Ivan.

Nature ; 587(7835): 657-662, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32726803

4.

SIK2 orchestrates actin-dependent host response upon Salmonella infection.

Hahn, Marcel; Covarrubias-Pinto, Adriana; Herhaus, Lina; Satpathy, Shankha; Klann, Kevin; Boyle, Keith B; Münch, Christian; Rajalingam, Krishnaraj; Randow, Felix; Choudhary, Chunaram; Dikic, Ivan.

Proc Natl Acad Sci U S A ; 118(19)2021 05 11.

Artigo em Inglês | MEDLINE | ID: mdl-33947818

5.

Patterning of Oncogenic Ras Clustering in Live Cells Using Vertically Aligned Nanostructure Arrays.

Mu, Huanwen; Zeng, Yongpeng; Zhuang, Yinyin; Gao, Weibo; Zhou, Yong; Rajalingam, Krishnaraj; Zhao, Wenting.

Nano Lett ; 22(3): 1007-1016, 2022 02 09.

Artigo em Inglês | MEDLINE | ID: mdl-35044178

6.

Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection.

Mukherjee, Rukmini; Bhattacharya, Anshu; Bojkova, Denisa; Mehdipour, Ahmad Reza; Shin, Donghyuk; Khan, Khadija Shahed; Hei-Yin Cheung, Hayley; Wong, Kam-Bo; Ng, Wai-Lung; Cinatl, Jindrich; Geurink, Paul P; van der Heden van Noort, Gerbrand J; Rajalingam, Krishnaraj; Ciesek, Sandra; Hummer, Gerhard; Dikic, Ivan.

J Biol Chem ; 297(2): 100925, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34214498

7.

Multiomic analysis of papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCÎ´ for tumorigenesis.

Renaud, Emilie; Riegel, Kristina; Romero, Rossana; Suryamohan, Kushal; Distler, Ute; Tenzer, Stefan; Schad, Arno; Musholt, Thomas J; Rajalingam, Krishnaraj.

Mol Cancer ; 21(1): 195, 2022 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-36217175

8.

Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity.

Buehler, Ulrike; Schulenburg, Katharina; Yurugi, Hajime; Solman, Maja; Abankwa, Daniel; Ulges, Alexander; Tenzer, Stefan; Bopp, Tobias; Thiede, Bernd; Zipp, Frauke; Rajalingam, Krishnaraj.

EMBO J ; 37(16)2018 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-30049713

9.

A subset of flavaglines inhibits KRAS nanoclustering and activation.

Yurugi, Hajime; Zhuang, Yinyin; Siddiqui, Farid A; Liang, Hong; Rosigkeit, Sebastian; Zeng, Yongpeng; Abou-Hamdan, Hussein; Bockamp, Ernesto; Zhou, Yong; Abankwa, Daniel; Zhao, Wenting; Désaubry, Laurent; Rajalingam, Krishnaraj.

J Cell Sci ; 133(12)2020 06 24.

Artigo em Inglês | MEDLINE | ID: mdl-32501281

10.

Regulation of mRNA export through API5 and nuclear FGF2 interaction.

Bong, Seoung Min; Bae, Seung-Hyun; Song, Bomin; Gwak, HyeRan; Yang, Seung-Won; Kim, Sunshin; Nam, Seungyoon; Rajalingam, Krishnaraj; Oh, Se Jin; Kim, Tae Woo; Park, SangYoun; Jang, Hyonchol; Lee, Byung Il.

Nucleic Acids Res ; 48(11): 6340-6352, 2020 06 19.

Artigo em Inglês | MEDLINE | ID: mdl-32383752

11.

Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.

Wiechmann, Svenja; Maisonneuve, Pierre; Grebbin, Britta M; Hoffmeister, Meike; Kaulich, Manuel; Clevers, Hans; Rajalingam, Krishnaraj; Kurinov, Igor; Farin, Henner F; Sicheri, Frank; Ernst, Andreas.

J Biol Chem ; 295(14): 4526-4540, 2020 04 03.

Artigo em Inglês | MEDLINE | ID: mdl-32086379

12.

Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases.

Wang, Dong; Tabti, Redouane; Elderwish, Sabria; Abou-Hamdan, Hussein; Djehal, Amel; Yu, Peng; Yurugi, Hajime; Rajalingam, Krishnaraj; Nebigil, Canan G; Désaubry, Laurent.

Cell Mol Life Sci ; 77(18): 3525-3546, 2020 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-32062751

13.

E4BP4/NFIL3 modulates the epigenetically repressed RAS effector RASSF8 function through histone methyltransferases.

Karthik, Isai Pratha; Desai, Pavitra; Sukumar, Sudarkodi; Dimitrijevic, Aleksandra; Rajalingam, Krishnaraj; Mahalingam, Sundarasamy.

J Biol Chem ; 293(15): 5624-5635, 2018 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-29467226

14.

The non-enzymatic RAS effector RASSF7 inhibits oncogenic c-Myc function.

Kumaraswamy, Anbarasu; Mamidi, Anitha; Desai, Pavitra; Sivagnanam, Ananthi; Perumalsamy, Lakshmi Revathi; Ramakrishnan, Chandrasekaran; Gromiha, Michael; Rajalingam, Krishnaraj; Mahalingam, Sundarasamy.

J Biol Chem ; 293(40): 15691-15705, 2018 10 05.

Artigo em Inglês | MEDLINE | ID: mdl-30139745

15.

Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2.

Imre, Gergely; Berthelet, Jean; Heering, Jan; Kehrloesser, Sebastian; Melzer, Inga Maria; Lee, Byung Il; Thiede, Bernd; Dötsch, Volker; Rajalingam, Krishnaraj.

EMBO Rep ; 18(5): 733-744, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28336776

16.

Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.

Takeda, Armelle-Natsuo; Oberoi-Khanuja, Tripat Kaur; Glatz, Gabor; Schulenburg, Katharina; Scholz, Rolf-Peter; Carpy, Alejandro; Macek, Boris; Remenyi, Attila; Rajalingam, Krishnaraj.

EMBO J ; 33(16): 1784-801, 2014 Aug 18.

Artigo em Inglês | MEDLINE | ID: mdl-24975362

17.

IAPs and cell migration.

Dubrez, Laurence; Rajalingam, Krishnaraj.

Semin Cell Dev Biol ; 39: 124-31, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-25769935

18.

IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation.

Oberoi, Tripat Kaur; Dogan, Taner; Hocking, Jennifer C; Scholz, Rolf-Peter; Mooz, Juliane; Anderson, Carrie L; Karreman, Christiaan; Meyer zu Heringdorf, Dagmar; Schmidt, Gudula; Ruonala, Mika; Namikawa, Kazuhiko; Harms, Gregory S; Carpy, Alejandro; Macek, Boris; Köster, Reinhard W; Rajalingam, Krishnaraj.

EMBO J ; 31(1): 14-28, 2012 Jan 04.

Artigo em Inglês | MEDLINE | ID: mdl-22117219

19.

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis.

Imre, Gergely; Heering, Jan; Takeda, Armelle-Natsuo; Husmann, Matthias; Thiede, Bernd; zu Heringdorf, Dagmar Meyer; Green, Douglas R; van der Goot, F Gisou; Sinha, Bhanu; Dötsch, Volker; Rajalingam, Krishnaraj.

EMBO J ; 31(11): 2615-28, 2012 May 30.

Artigo em Inglês | MEDLINE | ID: mdl-22531785

20.

A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation.

Hornburger, Michael C; Mayer, Bettina A; Leonhardt, Stefanie; Willer, Elisabeth A; Zahler, Stefan; Beyerle, Andrea; Rajalingam, Krishnaraj; Vollmar, Angelika M; Fürst, Robert.

FASEB J ; 28(4): 1938-46, 2014 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-24371121

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