Detalhe da pesquisa
1.
Circulating microRNAs as promising testicular translatable safety biomarkers: current state and future perspectives.
Arch Toxicol
; 97(4): 947-961, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36795116
2.
A Biomarker-Centric Approach to Drug Discovery and Development: Lessons Learned from the Coronavirus Disease 2019 Pandemic.
J Pharmacol Exp Ther
; 376(1): 12-20, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33115823
3.
Nephron segment specific microRNA biomarkers of pre-clinical drug-induced renal toxicity: Opportunities and challenges.
Toxicol Appl Pharmacol
; 312: 34-41, 2016 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26827821
4.
Regulatory Forum Opinion Piece*: Veterinary Pathologists in Translational Pharmacology and Biomarker Integration in Drug Discovery and Development.
Toxicol Pathol
; 44(2): 137-46, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26839329
5.
Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.
J Immunol
; 191(9): 4540-50, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24068666
6.
Nontraditional applications in clinical pathology.
Toxicol Pathol
; 42(7): 1058-68, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24705882
7.
Mechanistic investigations of test article-induced pancreatic toxicity at the endocrine-exocrine interface in the rat.
Toxicol Pathol
; 42(1): 229-42, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24226507
8.
Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case-control study.
Diagn Progn Res
; 7(1): 18, 2023 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37697410
9.
Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.
Nat Commun
; 14(1): 1215, 2023 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36869085
10.
Evaluation of potential gastrointestinal biomarkers in a PAK4 inhibitor-treated preclinical toxicity model to address unmonitorable gastrointestinal toxicity.
Toxicol Pathol
; 40(3): 482-90, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22395791
11.
Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species.
Mol Ther Methods Clin Dev
; 25: 264-277, 2022 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35505662
12.
Best practices for evaluation of bone marrow in nonclinical toxicity studies.
Toxicol Pathol
; 39(2): 435-48, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21300792
13.
Safety and disease monitoring biomarkers in Duchenne muscular dystrophy: results from a Phase II trial.
Biomark Med
; 15(15): 1389-1396, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34533053
14.
Evaluating the Sensitivity and Specificity of Promising Circulating Biomarkers to Diagnose Liver Injury in Humans.
Toxicol Sci
; 181(1): 23-34, 2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483742
15.
Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury.
Regul Toxicol Pharmacol
; 56(3): 237-46, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19903504
16.
Next-Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development.
Clin Pharmacol Ther
; 107(2): 333-346, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31314926
17.
The influence of estrogen on hepatobiliary osteopontin (SPP1) expression in a female rodent model of alcoholic steatohepatitis.
Toxicol Pathol
; 37(4): 492-501, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19387089
18.
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.
Cancer Res
; 67(6): 2816-23, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17363604
19.
Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways.
Cancer Res
; 67(2): 674-83, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234778
20.
Identification of proteins to predict the molecular basis for the observed gender susceptibility in a rat model of alcoholic steatohepatitis by 2-D gel proteomics.
Proteomics
; 8(20): 4327-37, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18924223