Detalhe da pesquisa
1.
Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein.
J Virol
; 86(12): 6643-55, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22496222
2.
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 23(9): 2585-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23545108
3.
Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Bioorg Med Chem Lett
; 23(24): 6879-85, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24176401
4.
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.
Bioorg Med Chem Lett
; 23(11): 3401-5, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23601710
5.
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Nature
; 426(6963): 186-9, 2003 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14578911
6.
Implementation of an electronic medical record in family practice: a case study.
Inform Prim Care
; 18(1): 31-40, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20429976
7.
Peptide-based inhibitors of the hepatitis C virus NS3 protease: structure-activity relationship at the C-terminal position.
J Med Chem
; 47(10): 2511-22, 2004 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15115394
8.
Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase.
J Med Chem
; 47(1): 18-21, 2004 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14695816
9.
A systematic approach to the optimization of substrate-based inhibitors of the hepatitis C virus NS3 protease: discovery of potent and specific tripeptide inhibitors.
J Med Chem
; 47(26): 6584-94, 2004 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15588093
10.
Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).
J Med Chem
; 57(5): 1845-54, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24159919
11.
Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallography.
ACS Chem Biol
; 8(5): 1074-82, 2013 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23496828
12.
Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486.
Antimicrob Agents Chemother
; 49(12): 4834-42, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16304143
13.
Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase.
J Virol
; 79(20): 13105-15, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16189012