[Epidemiological characterisation of acute and chronic hepatitis B in Uzbekistan]. / Epidemiologicheskaia kharakteristika ostrogo i khronicheskogo gepatita B v Uzbekistane.

The epidemiological survey of 126 foci with patients having acute hepatitis B (AHB) and 120 foci with patients having chronic hepatitis B (CHB) was conducted. The observation of the susceptible members of the family showed that a significantly higher level of infection was found in persons having contacts with CHB patients (44.4 +/- 2.3%) in comparison with the members of the families of AHB patients (33.2 +/- 2.3%). The study revealed that children under 14 years were actively involved into the epidemic process; in these children the highest levels of infection were observed in the families of AHB patients (40.2 +/- 3.7%) and CHB patients (57.1 +/- 3.5%). High detection rate of HbsAg were noted in brothers and sisters in the foci of AHB (42.3 +/- 6.4%) and the foci of CHB (52.3 +/- 5.4%), also in parents: 32.4 +/- 5.2% and 46.5 +/- 4.2%, in children: 28.8 +/- 3.4% and 35.6 +/- 3.6% respectively.

[The neutrophil receptor apparatus in typhoid fever]. / Retseptornyi apparat neitrofilov pri briushnom tife.

In 157 typhoid fever patients and 36 practically healthy persons the content of neutrophils forming complement-dependent rosettes (NEAC rosette-forming cells), as well as rosettes with sheep red blood cells (NE rosette-forming cells) and with typhoid erythrocyte diagnosticum (NS rosette-forming cells), has been studied. The data obtained in this investigation indicate that antigen-binding neutrophils play an active functional role in the pathogenesis of typhoid fever at its acute stage. The values characterizing the content of N rosette-forming cells may be used as a criterion for the evaluation of the severity of infection, as well as for the prognostication of complications and relapses.

[Clinical course and treatment regimes of Salmonella infection in children]. / Klinicheskoe techenie i sposoby lecheniia sal'monelleznoi infektsii u detei.

Salmonella infection in children caused by polyresistant S. typhimurium strains is characterized by a highly severe course with possible complications. In the treatment of young children with salmonellosis the use of the locally manufactured biologically active additive Bektit-M, possessing adsorption capacity, is recommended. The use of this preparation in complex treatment has made it possible to establish its clinical effect and positive influence on the biochemical characteristics of the blood.

[Cellular immunity and phagocytosis in pregnant patients with viral hepatitis B]. / Sostoianie kletochnogo immuniteta i fagotsitoza u beremennykh, bol'nykh virusnym gepatitom B.

The work deals with the results of the study of cell-mediated immunity factors (T and B lymphocytes, 0 lymphocytes, T helpers, T suppressors) and phagocytosis in pregnant women with viral hepatitis B, depending on the duration of pregnancy and the severity of the disease. The authors suggest that the severe course of viral hepatitis B in pregnant women may be regarded as the consequence of secondary immunodeficiency.

[The clinico-allergic indices of yersiniosis patients]. / Kliniko-allergicheskie pokazateli u bol'nykh iersiniozami.

Eighty patients with yersiniosis (40 with intestinal yersiniosis, 40 with pseudotuberculosis) were examined for clinical and allergic characteristics (collection of allergological histories, identification of the most common allergic symptoms of the disease and determination of the index of mast cell degranulation). According to the data obtained, the patients with yersiniosis are admitted to the hospital with an aggravated premorbid condition in the form of body allergization, in whose origin both hereditary and acquired factors are of importance. The allergic manifestations of the disease are more pronounced in patients with pseudotuberculosis. In the acute disease period, noticeable allergization of the sick body develops whatever the gravity of the disease in both infections whereas during convalescence, only in patients with the recurrent infectious process.

[Coamide stimulation of immunogenesis during experimental levomycetin therapy]. / Izuchenie stimuliatsii immunogeneza koamida pri levomitsetino-terapii v éksperimente.

The effect of various doses of levomycetin on immunogenesis and capacity of coamide for stimulation of immunogenesis in levomycetin therapy was studied. It was found that massive five-fold doses of levomycetin sodium succinate (I and 0.5 g/kg) administered parenterally or orally inhibited immunogenesis, the inhibition being more pronounced on administration of the antibiotic per os. When levomycetin sodium succinate was used in massive doses (1 g/kg) in combination with coamide (0.5 mg/kg) the inhibition of the immune response to the antigenic stimulation was less pronounced.