Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice.

Zhou, Junsong; Wu, Yi; Rauova, Lubica; Koma, Gavin; Wang, Lu; Poncz, Mortimer; Li, Hong; Liu, Tong; Fong, Karen P; Bennett, Joel S; Kunapuli, Satya P; Essex, David W.

Blood ; 139(13): 2050-2065, 2022 03 31.

Artigo em Inglês | MEDLINE | ID: mdl-34752599

2.

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes.

Khandelwal, Sanjay; Barnes, Ayiesha; Rauova, Lubica; Sarkar, Amrita; Rux, Ann H; Yarovoi, Serge V; Zaitsev, S Sergei; Lambris, John D; Myoung, Sooho S; Johnson, Alexandra; Lee, Grace M; Duarte, Madelaine; Poncz, Mortimer; Arepally, Gowthami M; Cines, Douglas B.

Blood ; 138(21): 2106-2116, 2021 11 25.

Artigo em Inglês | MEDLINE | ID: mdl-34189574

3.

Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.

Gollomp, Kandace; Sarkar, Amrita; Harikumar, Sanjiv; Seeholzer, Steven H; Arepally, Gowthami M; Hudock, Kristin; Rauova, Lubica; Kowalska, M Anna; Poncz, Mortimer.

Blood ; 135(10): 743-754, 2020 03 05.

Artigo em Inglês | MEDLINE | ID: mdl-31722003

4.

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.

Johnston, Ian; Sarkar, Amrita; Hayes, Vincent; Koma, Gavin T; Arepally, Gowthami M; Chen, Junmei; Chung, Dominic W; López, José A; Cines, Douglas B; Rauova, Lubica; Poncz, Mortimer.

Blood ; 135(15): 1270-1280, 2020 04 09.

Artigo em Inglês | MEDLINE | ID: mdl-32077913

5.

FcRn augments induction of tissue factor activity by IgG-containing immune complexes.

Cines, Douglas B; Zaitsev, Sergei; Rauova, Lubica; Rux, Ann H; Stepanova, Victoria; Krishnaswamy, Sriram; Sarkar, Amrita; Kowalska, M Anna; Zhao, Guohua; Mast, Alan E; Blumberg, Laurence J; McCrae, Keith R; Poncz, Mortimer; Hubbard, Jonathan J; Pyzik, Michal; Blumberg, Richard S.

Blood ; 135(23): 2085-2093, 2020 06 04.

Artigo em Inglês | MEDLINE | ID: mdl-32187355

6.

In systemic lupus erythematosus anti-dsDNA antibodies can promote thrombosis through direct platelet activation.

Andrianova, Izabella A; Ponomareva, Anastasiya A; Mordakhanova, Elmira R; Le Minh, Giang; Daminova, Amina G; Nevzorova, Tatiana A; Rauova, Lubica; Litvinov, Rustem I; Weisel, John W.

J Autoimmun ; 107: 102355, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31732191

7.

Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.

Dai, Jing; Madeeva, Daria; Hayes, Vincent; Ahn, Hyun Sook; Tutwiler, Valerie; Arepally, Gowthami M; Cines, Douglas B; Poncz, Mortimer; Rauova, Lubica.

Blood ; 132(7): 727-734, 2018 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-29914979

8.

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.

Khandelwal, Sanjay; Ravi, Joann; Rauova, Lubica; Johnson, Alexandra; Lee, Grace M; Gilner, Jennifer B; Gunti, Sreenivasulu; Notkins, Abner L; Kuchibhatla, Maragatha; Frank, Michael; Poncz, Mortimer; Cines, Douglas B; Arepally, Gowthami M.

Blood ; 132(23): 2431-2440, 2018 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-30309891

9.

Platelet Activation in Heparin-Induced Thrombocytopenia is Followed by Platelet Death via Complex Apoptotic and Non-Apoptotic Pathways.

Mordakhanova, Elmira R; Nevzorova, Tatiana A; Synbulatova, Gulnaz E; Rauova, Lubica; Weisel, John W; Litvinov, Rustem I.

Int J Mol Sci ; 21(7)2020 Apr 07.

Artigo em Inglês | MEDLINE | ID: mdl-32272655

10.

Platelets get particular.

Rauova, Lubica; Cines, Douglas B.

Blood ; 140(5): 413-414, 2022 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-35925641

11.

The disulfide isomerase ERp72 supports arterial thrombosis in mice.

Zhou, Junsong; Wu, Yi; Chen, Fengwu; Wang, Lu; Rauova, Lubica; Hayes, Vincent M; Poncz, Mortimer; Li, Hong; Liu, Tong; Liu, Junling; Essex, David W.

Blood ; 130(6): 817-828, 2017 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-28576878

12.

Understanding VITT(ual) reality.

Rauova, Lubica; Poncz, Mortimer.

Blood ; 138(4): 285-286, 2021 07 29.

Artigo em Inglês | MEDLINE | ID: mdl-34323943

13.

The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).

Khandelwal, Sanjay; Lee, Grace M; Hester, C Garren; Poncz, Mortimer; McKenzie, Steven E; Sachais, Bruce S; Rauova, Lubica; Kelsoe, Garnett; Cines, Douglas B; Frank, Michael; Arepally, Gowthami M.

Blood ; 128(14): 1789-1799, 2016 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-27412887

14.

Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia.

Tutwiler, Valerie; Madeeva, Daria; Ahn, Hyun Sook; Andrianova, Izabella; Hayes, Vincent; Zheng, X Long; Cines, Douglas B; McKenzie, Steven E; Poncz, Mortimer; Rauova, Lubica.

Blood ; 127(4): 464-72, 2016 Jan 28.

Artigo em Inglês | MEDLINE | ID: mdl-26518435

15.

Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin.

Cines, Douglas B; Lebedeva, Tatiana; Nagaswami, Chandrasekaran; Hayes, Vincent; Massefski, Walter; Litvinov, Rustem I; Rauova, Lubica; Lowery, Thomas J; Weisel, John W.

Blood ; 123(10): 1596-603, 2014 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-24335500

16.

Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.

Zhi, Huiying; Rauova, Lubica; Hayes, Vincent; Gao, Cunji; Boylan, Brian; Newman, Debra K; McKenzie, Steven E; Cooley, Brian C; Poncz, Mortimer; Newman, Peter J.

Blood ; 121(10): 1858-67, 2013 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-23264598

17.

Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.

Litvinov, Rustem I; Yarovoi, Serge V; Rauova, Lubica; Barsegov, Valeri; Sachais, Bruce S; Rux, Ann H; Hinds, Jillian L; Arepally, Gowthami M; Cines, Douglas B; Weisel, John W.

J Biol Chem ; 288(46): 33060-70, 2013 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-24097975

18.

T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept.

Skewis, Lynell R; Lebedeva, Tatiana; Papkov, Vyacheslav; Thayer, Edward C; Massefski, Walter; Cuker, Adam; Nagaswami, Chandrasekaran; Litvinov, Rustem I; Kowalska, M Anna; Rauova, Lubica; Poncz, Mortimer; Weisel, John W; Lowery, Thomas J; Cines, Douglas B.

Clin Chem ; 60(9): 1174-82, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-24958814

19.

"Radical" model of thrombosis.

Rauova, Lubica.

Blood ; 119(8): 1798-9, 2012 Feb 23.

Artigo em Inglês | MEDLINE | ID: mdl-22361971

20.

Dynamic antibody-binding properties in the pathogenesis of HIT.

Sachais, Bruce S; Litvinov, Rustem I; Yarovoi, Serge V; Rauova, Lubica; Hinds, Jillian L; Rux, Ann H; Arepally, Gowthami M; Poncz, Mortimer; Cuker, Adam; Weisel, John W; Cines, Douglas B.

Blood ; 120(5): 1137-42, 2012 Aug 02.

Artigo em Inglês | MEDLINE | ID: mdl-22577175

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