Detalhe da pesquisa
1.
Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody.
Cancer Immunol Immunother
; 71(2): 473-489, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-34247273
2.
Phase 1 study of anti-CD47 monoclonal antibody CC-90002 in patients with relapsed/refractory acute myeloid leukemia and high-risk myelodysplastic syndromes.
Ann Hematol
; 101(3): 557-569, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34981142
3.
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.
Blood
; 126(6): 779-89, 2015 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26002965
4.
Pomalidomide in combination with dexamethasone results in synergistic anti-tumour responses in pre-clinical models of lenalidomide-resistant multiple myeloma.
Br J Haematol
; 172(6): 889-901, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26914976
5.
An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin.
Br J Haematol
; 165(6): 870-82, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24635723
6.
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.
Bioorg Med Chem Lett
; 22(3): 1427-32, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22226655
7.
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.
Bioorg Med Chem Lett
; 22(3): 1433-8, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22244937
8.
1,1-Diarylalkenes as anticancer agents: dual inhibitors of tubulin polymerization and phosphodiesterase 4.
Bioorg Med Chem
; 19(21): 6356-74, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21955454
9.
First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy.
Cancer Manag Res
; 11: 10463-10476, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31853198
10.
Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies.
Clin Cancer Res
; 25(18): 5623-5637, 2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31266833
11.
The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-alpha production with antitumor activity.
Cancer Res
; 66(2): 951-9, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16424030
12.
Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1-S Checkpoint.
Mol Cancer Ther
; 17(8): 1727-1738, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29866747
13.
CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro.
Oncotarget
; 8(43): 74688-74702, 2017 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29088817
14.
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.
Mol Cancer Ther
; 14(6): 1295-305, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25855786
15.
Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
J Med Chem
; 58(13): 5323-33, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26083478
16.
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.
J Med Chem
; 58(14): 5599-608, 2015 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26102506
17.
Small molecule inhibitors of cell signaling: novel future therapeutics for asthma and chronic obstructive pulmonary diseases.
Curr Opin Investig Drugs
; 4(5): 544-51, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12833647
18.
The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.
Clin Cancer Res
; 19(20): 5722-32, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24030701
19.
Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.
J Med Chem
; 52(6): 1522-4, 2009 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19256507
20.
Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line--studies in vitro and after intracerebral grafting in vivo.
Mol Cell Neurosci
; 34(3): 390-9, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17222562