Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer.

Wagner, Johanna; Rapsomaniki, Maria Anna; Chevrier, Stéphane; Anzeneder, Tobias; Langwieder, Claus; Dykgers, August; Rees, Martin; Ramaswamy, Annette; Muenst, Simone; Soysal, Savas Deniz; Jacobs, Andrea; Windhager, Jonas; Silina, Karina; van den Broek, Maries; Dedes, Konstantin Johannes; Rodríguez Martínez, Maria; Weber, Walter Paul; Bodenmiller, Bernd.

Cell ; 177(5): 1330-1345.e18, 2019 05 16.

Artigo em Inglês | MEDLINE | ID: mdl-30982598

2.

Structure of the native myosin filament in the relaxed cardiac sarcomere.

Tamborrini, Davide; Wang, Zhexin; Wagner, Thorsten; Tacke, Sebastian; Stabrin, Markus; Grange, Michael; Kho, Ay Lin; Rees, Martin; Bennett, Pauline; Gautel, Mathias; Raunser, Stefan.

Nature ; 623(7988): 863-871, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37914933

3.

Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing.

Park-Holohan, So-Jin; Brunello, Elisabetta; Kampourakis, Thomas; Rees, Martin; Irving, Malcolm; Fusi, Luca.

Proc Natl Acad Sci U S A ; 118(16)2021 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-33850019

4.

Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation.

Rees, Martin; Nikoopour, Roksana; Alexandrovich, Alexander; Pfuhl, Mark; Lopes, Luis R; Akhtar, Mohammed M; Syrris, Petros; Elliott, Perry; Carr-White, Gerry; Gautel, Mathias.

J Struct Biol ; 215(3): 108009, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37549721

5.

When is an obscurin variant pathogenic? The impact of Arg4344Gln and Arg4444Trp variants on protein-protein interactions and protein stability.

Fukuzawa, Atsushi; Koch, Daniel; Grover, Sarah; Rees, Martin; Gautel, Mathias.

Hum Mol Genet ; 30(12): 1131-1141, 2021 06 09.

Artigo em Inglês | MEDLINE | ID: mdl-33438037

6.

Mars: do we still need astronauts?

Goldsmith, Donald; Rees, Martin.

Nature ; 606(7914): 463, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35701621

7.

Making sense of missense variants in TTN-related congenital myopathies.

Rees, Martin; Nikoopour, Roksana; Fukuzawa, Atsushi; Kho, Ay Lin; Fernandez-Garcia, Miguel A; Wraige, Elizabeth; Bodi, Istvan; Deshpande, Charu; Özdemir, Özkan; Daimagüler, Hülya-Sevcan; Pfuhl, Mark; Holt, Mark; Brandmeier, Birgit; Grover, Sarah; Fluss, Joël; Longman, Cheryl; Farrugia, Maria Elena; Matthews, Emma; Hanna, Michael; Muntoni, Francesco; Sarkozy, Anna; Phadke, Rahul; Quinlivan, Ros; Oates, Emily C; Schröder, Rolf; Thiel, Christian; Reimann, Jens; Voermans, Nicol; Erasmus, Corrie; Kamsteeg, Erik-Jan; Konersman, Chaminda; Grosmann, Carla; McKee, Shane; Tirupathi, Sandya; Moore, Steven A; Wilichowski, Ekkehard; Hobbiebrunken, Elke; Dekomien, Gabriele; Richard, Isabelle; Van den Bergh, Peter; Domínguez-González, Cristina; Cirak, Sebahattin; Ferreiro, Ana; Jungbluth, Heinz; Gautel, Mathias.

Acta Neuropathol ; 141(3): 431-453, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33449170

8.

Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase.

Maiocchi, Sophie; Ku, Jacqueline; Hawtrey, Tom; De Silvestro, Irene; Malle, Ernst; Rees, Martin; Thomas, Shane R; Morris, Jonathan C.

Chem Res Toxicol ; 34(6): 1681-1692, 2021 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-34085520

9.

COVID-19 shows UK-EU collaborations are irreplaceable.

Fernando, Benjamin; Brown, Gordon; Thomas, Emily; Head, Michael; Nurse, Paul; Rees, Martin.

Nature ; 586(7828): 200, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32963368

10.

Impact of molecular subtypes on the prediction of distant recurrence in estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer upon five years of endocrine therapy.

Laible, Mark; Hartmann, Kerstin; Gürtler, Claudia; Anzeneder, Tobias; Wirtz, Ralph; Weber, Stephan; Keller, Thomas; Sahin, Ugur; Rees, Martin; Ramaswamy, Annette.

BMC Cancer ; 19(1): 694, 2019 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-31307414

11.

Stephen Hawking (1942-2018).

Rees, Martin.

Nature ; 555(7697): 444, 2018 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-32034344

12.

Extraction of Ejection Fraction from Echocardiography Notes for Constructing a Cohort of Patients having Heart Failure with reduced Ejection Fraction (HFrEF).

Wagholikar, Kavishwar B; Fischer, Christina M; Goodson, Alyssa; Herrick, Christopher D; Rees, Martin; Toscano, Eloy; MacRae, Calum A; Scirica, Benjamin M; Desai, Akshay S; Murphy, Shawn N.

J Med Syst ; 42(11): 209, 2018 Sep 25.

Artigo em Inglês | MEDLINE | ID: mdl-30255347

13.

UK research reform: poor timing.

Rees, Martin.

Nature ; 539(7629): 357, 2016 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-27853205

14.

Donald Lynden-Bell (1935-2018).

Rees, Martin J.

Proc Natl Acad Sci U S A ; 115(14): 3510-3511, 2018 04 03.

Artigo em Inglês | MEDLINE | ID: mdl-29549151

15.

A Longitude Prize for the twenty-first century.

Rees, Martin.

Nature ; 509(7501): 401, 2014 May 22.

Artigo em Inglês | MEDLINE | ID: mdl-24848027

16.

Human indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide.

Freewan, Mohammed; Rees, Martin D; Plaza, Tito S Sempértegui; Glaros, Elias; Lim, Yean J; Wang, Xiao Suo; Yeung, Amanda W S; Witting, Paul K; Terentis, Andrew C; Thomas, Shane R.

J Biol Chem ; 288(3): 1548-67, 2013 Jan 18.

Artigo em Inglês | MEDLINE | ID: mdl-23209301

17.

Time for global statistics we can count on.

Rees, Martin.

Nature ; 502(7471): 273, 2013 Oct 17.

Artigo em Inglês | MEDLINE | ID: mdl-24132252

18.

Walking with giants: The challenges of variant impact assessment in the giant sarcomeric protein titin.

Weston, Timir G R; Rees, Martin; Gautel, Mathias; Fraternali, Franca.

WIREs Mech Dis ; 16(2): e1638, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38155593

19.

Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold.

de Chiara, Cesira; Rees, Martin; Menon, Raj P; Pauwels, Kris; Lawrence, Ceri; Konarev, Petr V; Svergun, Dmitri I; Martin, Stephen R; Chen, Yu Wai; Pastore, Annalisa.

Biophys J ; 104(6): 1304-13, 2013 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-23528090

20.

Cancer-associated fibroblast classification in single-cell and spatial proteomics data.

Cords, Lena; Tietscher, Sandra; Anzeneder, Tobias; Langwieder, Claus; Rees, Martin; de Souza, Natalie; Bodenmiller, Bernd.

Nat Commun ; 14(1): 4294, 2023 07 18.

Artigo em Inglês | MEDLINE | ID: mdl-37463917

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A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer.

Structure of the native myosin filament in the relaxed cardiac sarcomere.

Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing.

Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation.

When is an obscurin variant pathogenic? The impact of Arg4344Gln and Arg4444Trp variants on protein-protein interactions and protein stability.

Mars: do we still need astronauts?

Making sense of missense variants in TTN-related congenital myopathies.

Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase.

COVID-19 shows UK-EU collaborations are irreplaceable.

Impact of molecular subtypes on the prediction of distant recurrence in estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer upon five years of endocrine therapy.

Stephen Hawking (1942-2018).

Extraction of Ejection Fraction from Echocardiography Notes for Constructing a Cohort of Patients having Heart Failure with reduced Ejection Fraction (HFrEF).

UK research reform: poor timing.

Donald Lynden-Bell (1935-2018).

A Longitude Prize for the twenty-first century.

Human indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide.

Time for global statistics we can count on.

Walking with giants: The challenges of variant impact assessment in the giant sarcomeric protein titin.

Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold.

Cancer-associated fibroblast classification in single-cell and spatial proteomics data.