Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Redox homeostasis maintained by GPX4 facilitates STING activation.

Jia, Mutian; Qin, Danhui; Zhao, Chunyuan; Chai, Li; Yu, Zhongxia; Wang, Wenwen; Tong, Li; Lv, Lin; Wang, Yuanyuan; Rehwinkel, Jan; Yu, Jinming; Zhao, Wei.

Nat Immunol ; 21(7): 727-735, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32541831

2.

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.

Tang, Qiannan; Rigby, Rachel E; Young, George R; Hvidt, Astrid Korning; Davis, Tanja; Tan, Tiong Kit; Bridgeman, Anne; Townsend, Alain R; Kassiotis, George; Rehwinkel, Jan.

Immunity ; 54(9): 1961-1975.e5, 2021 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-34525337

3.

Interferon induction held captive in tumor cells.

Bridgeman, Anne; Rehwinkel, Jan.

Mol Cell ; 81(20): 4109-4110, 2021 10 21.

Artigo em Inglês | MEDLINE | ID: mdl-34686311

4.

ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.

Roderick-Richardson, Justine E; Lim, Sung-Eun; Suzuki, Sakiko; Ahmad, Mohd Hafiz; Selway, Jonathan; Suleiman, Reem; Karna, Keshab; Lehman, Jesse; O'Donnell, Joanne; Castilla, Lucio H; Maelfait, Jonathan; Rehwinkel, Jan; Kelliher, Michelle A.

Proc Natl Acad Sci U S A ; 121(4): e2309628121, 2024 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-38227660

5.

Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.

Hertzog, Jonny; Zhou, Wen; Fowler, Gerissa; Rigby, Rachel E; Bridgeman, Anne; Blest, Henry Tw; Cursi, Chiara; Chauveau, Lise; Davenne, Tamara; Warner, Benjamin E; Kinchington, Paul R; Kranzusch, Philip J; Rehwinkel, Jan.

EMBO J ; 41(14): e109217, 2022 07 18.

Artigo em Inglês | MEDLINE | ID: mdl-35670106

6.

RECONsidering Sensing of Cyclic Dinucleotides.

Maelfait, Jonathan; Rehwinkel, Jan.

Immunity ; 46(3): 337-339, 2017 03 21.

Artigo em Inglês | MEDLINE | ID: mdl-28329697

7.

RIG-I detects viral genomic RNA during negative-strand RNA virus infection.

Rehwinkel, Jan; Tan, Choon Ping; Goubau, Delphine; Schulz, Oliver; Pichlmair, Andreas; Bier, Katja; Robb, Nicole; Vreede, Frank; Barclay, Wendy; Fodor, Ervin; Reis e Sousa, Caetano.

Cell ; 140(3): 397-408, 2010 Feb 05.

Artigo em Inglês | MEDLINE | ID: mdl-20144762

8.

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.

Erdal, Erkin; Haider, Syed; Rehwinkel, Jan; Harris, Adrian L; McHugh, Peter J.

Genes Dev ; 31(4): 353-369, 2017 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-28279982

9.

SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.

Husain, Afzal; Xu, Jianliang; Fujii, Hodaka; Nakata, Mikiyo; Kobayashi, Maki; Wang, Ji-Yang; Rehwinkel, Jan; Honjo, Tasuku; Begum, Nasim A.

EMBO J ; 39(15): e102931, 2020 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-32511795

10.

Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.

Peng, Ruoshi; Wang, Chris Kedong; Wang-Kan, Xuan; Idorn, Manja; Kjaer, Majken; Zhou, Felix Y; Fiil, Berthe Katrine; Timmermann, Frederik; Orozco, Susana L; McCarthy, Julia; Leung, Carol S; Lu, Xin; Bagola, Katrin; Rehwinkel, Jan; Oberst, Andrew; Maelfait, Jonathan; Paludan, Søren R; Gyrd-Hansen, Mads.

EMBO Rep ; 23(12): e55839, 2022 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-36268590

11.

Mitochondrial double-stranded RNA triggers antiviral signalling in humans.

Dhir, Ashish; Dhir, Somdutta; Borowski, Lukasz S; Jimenez, Laura; Teitell, Michael; Rötig, Agnès; Crow, Yanick J; Rice, Gillian I; Duffy, Darragh; Tamby, Christelle; Nojima, Takayuki; Munnich, Arnold; Schiff, Manuel; de Almeida, Claudia Ribeiro; Rehwinkel, Jan; Dziembowski, Andrzej; Szczesny, Roman J; Proudfoot, Nicholas J.

Nature ; 560(7717): 238-242, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-30046113

12.

2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice.

Rodríguez-Carrio, Javier; Burska, Agata; Conaghan, Philip G; Dik, Willem A; Biesen, Robert; Eloranta, Maija-Leena; Cavalli, Giulio; Visser, Marianne; Boumpas, Dimitrios T; Bertsias, George; Wahren-Herlenius, Marie; Rehwinkel, Jan; Frémond, Marie-Louise; Crow, Mary K; Rönnblom, Lars; Versnel, Marjan A; Vital, Edward M.

Ann Rheum Dis ; 82(6): 754-762, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-36858821

13.

Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.

Chauveau, Lise; Bridgeman, Anne; Tan, Tiong K; Beveridge, Ryan; Frost, Joe N; Rijal, Pramila; Pedroza-Pacheco, Isabela; Partridge, Thomas; Gilbert-Jaramillo, Javier; Knight, Michael L; Liu, Xu; Russell, Rebecca A; Borrow, Persephone; Drakesmith, Hal; Townsend, Alain R; Rehwinkel, Jan.

EMBO Rep ; 22(8): e52447, 2021 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-34142428

14.

Regulation and inhibition of the DNA sensor cGAS.

Hertzog, Jonny; Rehwinkel, Jan.

EMBO Rep ; 21(12): e51345, 2020 12 03.

Artigo em Inglês | MEDLINE | ID: mdl-33155371

15.

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.

Maelfait, Jonathan; Liverpool, Layal; Bridgeman, Anne; Ragan, Katherine B; Upton, Jason W; Rehwinkel, Jan.

EMBO J ; 36(17): 2529-2543, 2017 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-28716805

16.

A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.

Mlcochova, Petra; Sutherland, Katherine A; Watters, Sarah A; Bertoli, Cosetta; de Bruin, Rob Am; Rehwinkel, Jan; Neil, Stuart J; Lenzi, Gina M; Kim, Baek; Khwaja, Asim; Gage, Matthew C; Georgiou, Christiana; Chittka, Alexandra; Yona, Simon; Noursadeghi, Mahdad; Towers, Greg J; Gupta, Ravindra K.

EMBO J ; 36(5): 604-616, 2017 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-28122869

17.

Deoxyguanosine is a TLR7 agonist.

Davenne, Tamara; Bridgeman, Anne; Rigby, Rachel E; Rehwinkel, Jan.

Eur J Immunol ; 50(1): 56-62, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31608988

18.

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.

Hansen, Anne Louise; Buchan, Gregory J; Rühl, Michael; Mukai, Kojiro; Salvatore, Sonia R; Ogawa, Emari; Andersen, Sidsel D; Iversen, Marie B; Thielke, Anne L; Gunderstofte, Camilla; Motwani, Mona; Møller, Charlotte T; Jakobsen, Andreas S; Fitzgerald, Katherine A; Roos, Jessica; Lin, Rongtuan; Maier, Thorsten J; Goldbach-Mansky, Raphaela; Miner, Cathrine A; Qian, Wei; Miner, Jonathan J; Rigby, Rachel E; Rehwinkel, Jan; Jakobsen, Martin R; Arai, Hiroyuki; Taguchi, Tomohiko; Schopfer, Francisco J; Olagnier, David; Holm, Christian K.

Proc Natl Acad Sci U S A ; 115(33): E7768-E7775, 2018 08 14.

Artigo em Inglês | MEDLINE | ID: mdl-30061387

19.

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.

Goubau, Delphine; Schlee, Martin; Deddouche, Safia; Pruijssers, Andrea J; Zillinger, Thomas; Goldeck, Marion; Schuberth, Christine; Van der Veen, Annemarthe G; Fujimura, Tsutomu; Rehwinkel, Jan; Iskarpatyoti, Jason A; Barchet, Winfried; Ludwig, Janos; Dermody, Terence S; Hartmann, Gunther; Reis e Sousa, Caetano.

Nature ; 514(7522): 372-375, 2014 10 16.

Artigo em Inglês | MEDLINE | ID: mdl-25119032

20.

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.

Hertzog, Jonny; Dias Junior, Antonio Gregorio; Rigby, Rachel E; Donald, Claire L; Mayer, Alice; Sezgin, Erdinc; Song, Chaojun; Jin, Boquan; Hublitz, Philip; Eggeling, Christian; Kohl, Alain; Rehwinkel, Jan.

Eur J Immunol ; 48(7): 1120-1136, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29572905

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