Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.

Erickson, Rebecca I; Schutt, Leah K; Tarrant, Jacqueline M; McDowell, Michelle; Liu, Lichuan; Johnson, Adam R; Lewin-Koh, Sock-Cheng; Hedehus, Maj; Ross, Jed; Carano, Richard A D; Staflin, Karin; Zhong, Fiona; Crawford, James J; Zhong, Shelly; Reif, Karin; Katewa, Arna; Wong, Harvey; Young, Wendy B; Dambach, Donna M; Misner, Dinah L.

J Pharmacol Exp Ther ; 360(1): 226-238, 2017 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-27821712

2.

Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies.

Tran, John C; Tran, Daniel; Hilderbrand, Amy; Andersen, Nisana; Huang, Tao; Reif, Karin; Hotzel, Isidro; Stefanich, Eric G; Liu, Yichin; Wang, Jianyong.

Anal Chem ; 88(23): 11521-11526, 2016 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-27797494

3.

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.

Young, Wendy B; Barbosa, James; Blomgren, Peter; Bremer, Meire C; Crawford, James J; Dambach, Donna; Eigenbrot, Charles; Gallion, Steve; Johnson, Adam R; Kropf, Jeffrey E; Lee, Seung H; Liu, Lichuan; Lubach, Joseph W; Macaluso, Jen; Maciejewski, Pat; Mitchell, Scott A; Ortwine, Daniel F; Di Paolo, Julie; Reif, Karin; Scheerens, Heleen; Schmitt, Aaron; Wang, Xiaojing; Wong, Harvey; Xiong, Jin-Ming; Xu, Jianjun; Yu, Christine; Zhao, Zhongdong; Currie, Kevin S.

Bioorg Med Chem Lett ; 26(2): 575-579, 2016 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-26675441

4.

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.

Young, Wendy B; Barbosa, James; Blomgren, Peter; Bremer, Meire C; Crawford, James J; Dambach, Donna; Gallion, Steve; Hymowitz, Sarah G; Kropf, Jeffrey E; Lee, Seung H; Liu, Lichuan; Lubach, Joseph W; Macaluso, Jen; Maciejewski, Pat; Maurer, Brigitte; Mitchell, Scott A; Ortwine, Daniel F; Di Paolo, Julie; Reif, Karin; Scheerens, Heleen; Schmitt, Aaron; Sowell, C Gregory; Wang, Xiaojing; Wong, Harvey; Xiong, Jin-Ming; Xu, Jianjun; Zhao, Zhongdong; Currie, Kevin S.

Bioorg Med Chem Lett ; 25(6): 1333-7, 2015 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-25701252

5.

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.

Di Paolo, Julie A; Huang, Tao; Balazs, Mercedesz; Barbosa, James; Barck, Kai H; Bravo, Brandon J; Carano, Richard A D; Darrow, James; Davies, Douglas R; DeForge, Laura E; Diehl, Lauri; Ferrando, Ronald; Gallion, Steven L; Giannetti, Anthony M; Gribling, Peter; Hurez, Vincent; Hymowitz, Sarah G; Jones, Randall; Kropf, Jeffrey E; Lee, Wyne P; Maciejewski, Patricia M; Mitchell, Scott A; Rong, Hong; Staker, Bart L; Whitney, J Andrew; Yeh, Sherry; Young, Wendy B; Yu, Christine; Zhang, Juan; Reif, Karin; Currie, Kevin S.

Nat Chem Biol ; 7(1): 41-50, 2011 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-21113169

6.

Identification of GNE-293, a potent and selective PI3KÎ´ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.

Safina, Brian S; Sweeney, Zachary K; Li, Jun; Chan, Bryan K; Bisconte, Angelina; Carrera, Diane; Castanedo, Georgette; Flagella, Michael; Heald, Robert; Lewis, Cristina; Murray, Jeremy M; Nonomiya, Jim; Pang, Jodie; Price, Steve; Reif, Karin; Salphati, Laurent; Seward, Eileen M; Wei, Binqing; Sutherlin, Daniel P.

Bioorg Med Chem Lett ; 23(17): 4953-9, 2013 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-23867164

7.

Potent and selective inhibitors of PI3KÎ´: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.

Sutherlin, Daniel P; Baker, Stewart; Bisconte, Angelina; Blaney, Paul M; Brown, Anthony; Chan, Bryan K; Chantry, David; Castanedo, Georgette; DePledge, Paul; Goldsmith, Paul; Goldstein, David M; Hancox, Timothy; Kaur, Jasmit; Knowles, David; Kondru, Rama; Lesnick, John; Lucas, Matthew C; Lewis, Cristina; Murray, Jeremy; Nadin, Alan J; Nonomiya, Jim; Pang, Jodie; Pegg, Neil; Price, Steve; Reif, Karin; Safina, Brian S; Salphati, Laurent; Staben, Steven; Seward, Eileen M; Shuttleworth, Stephen; Sohal, Sukhjit; Sweeney, Zachary K; Ultsch, Mark; Waszkowycz, Bohdan; Wei, Binqing.

Bioorg Med Chem Lett ; 22(13): 4296-302, 2012 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-22672799

8.

CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosis.

Liu, Yingru; Bando, Yoshio; Vargas-Lowy, David; Elyaman, Wassim; Khoury, Samia J; Huang, Tao; Reif, Karin; Chitnis, Tanuja.

J Neurosci ; 30(6): 2025-38, 2010 Feb 10.

Artigo em Inglês | MEDLINE | ID: mdl-20147531

9.

Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy.

Liu, Lichuan; Di Paolo, Julie; Barbosa, Jim; Rong, Hong; Reif, Karin; Wong, Harvey.

J Pharmacol Exp Ther ; 338(1): 154-63, 2011 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-21521773

10.

Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity.

Crawford, James J; Lee, Wendy; Johnson, Adam R; Delatorre, Kelly J; Chen, Jacob; Eigenbrot, Charles; Heidmann, Julia; Kakiuchi-Kiyota, Satoko; Katewa, Arna; Kiefer, James R; Liu, Lichuan; Lubach, Joseph W; Misner, Dinah; Purkey, Hans; Reif, Karin; Vogt, Jennifer; Wong, Harvey; Yu, Christine; Young, Wendy B.

ACS Med Chem Lett ; 11(8): 1588-1597, 2020 Aug 13.

Artigo em Inglês | MEDLINE | ID: mdl-32832028

11.

The CDM protein DOCK2 in lymphocyte migration.

Reif, Karin; Cyster, Jason.

Trends Cell Biol ; 12(8): 368-73, 2002 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-12191913

12.

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.

Crawford, James J; Johnson, Adam R; Misner, Dinah L; Belmont, Lisa D; Castanedo, Georgette; Choy, Regina; Coraggio, Melis; Dong, Liming; Eigenbrot, Charles; Erickson, Rebecca; Ghilardi, Nico; Hau, Jonathan; Katewa, Arna; Kohli, Pawan Bir; Lee, Wendy; Lubach, Joseph W; McKenzie, Brent S; Ortwine, Daniel F; Schutt, Leah; Tay, Suzanne; Wei, BinQing; Reif, Karin; Liu, Lichuan; Wong, Harvey; Young, Wendy B.

J Med Chem ; 61(6): 2227-2245, 2018 03 22.

Artigo em Inglês | MEDLINE | ID: mdl-29457982

13.

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.

Wang, Xiaojing; Barbosa, James; Blomgren, Peter; Bremer, Meire C; Chen, Jacob; Crawford, James J; Deng, Wei; Dong, Liming; Eigenbrot, Charles; Gallion, Steve; Hau, Jonathon; Hu, Huiyong; Johnson, Adam R; Katewa, Arna; Kropf, Jeffrey E; Lee, Seung H; Liu, Lichuan; Lubach, Joseph W; Macaluso, Jen; Maciejewski, Pat; Mitchell, Scott A; Ortwine, Daniel F; DiPaolo, Julie; Reif, Karin; Scheerens, Heleen; Schmitt, Aaron; Wong, Harvey; Xiong, Jin-Ming; Xu, Jianjun; Zhao, Zhongdong; Zhou, Fusheng; Currie, Kevin S; Young, Wendy B.

ACS Med Chem Lett ; 8(6): 608-613, 2017 Jun 08.

Artigo em Inglês | MEDLINE | ID: mdl-28626519

14.

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.

Katewa, Arna; Wang, Yugang; Hackney, Jason A; Huang, Tao; Suto, Eric; Ramamoorthi, Nandhini; Austin, Cary D; Bremer, Meire; Chen, Jacob Zhi; Crawford, James J; Currie, Kevin S; Blomgren, Peter; DeVoss, Jason; DiPaolo, Julie A; Hau, Jonathan; Johnson, Adam; Lesch, Justin; DeForge, Laura E; Lin, Zhonghua; Liimatta, Marya; Lubach, Joseph W; McVay, Sami; Modrusan, Zora; Nguyen, Allen; Poon, Chungkee; Wang, Jianyong; Liu, Lichuan; Lee, Wyne P; Wong, Harvey; Young, Wendy B; Townsend, Michael J; Reif, Karin.

JCI Insight ; 2(7): e90111, 2017 04 06.

Artigo em Inglês | MEDLINE | ID: mdl-28405610

15.

Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.

Rajapaksa, Kathila S; Huang, Tao; Sharma, Neeraj; Liu, Shannon; Solon, Margaret; Reyes, Arthur; Paul, Sarah; Yee, Angie; Tao, Janet; Chalasani, Sreedevi; Bien-Ly, Nga; Barck, Kai; Carano, Richard A D; Wang, Jianyong; Rangell, Linda; Bremer, Meire; Danilenko, Dimitry M; Katavolos, Paula; Hotzel, Isidro; Reif, Karin; Austin, Cary D.

Toxicol Sci ; 152(1): 72-84, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27103662

16.

Depletion of major pathogenic cells in asthma by targeting CRTh2.

Huang, Tao; Hazen, Meredith; Shang, Yonglei; Zhou, Meijuan; Wu, Xiumin; Yan, Donghong; Lin, Zhonghua; Solon, Margaret; Luis, Elizabeth; Ngu, Hai; Shi, Yongchang; Katewa, Arna; Choy, David F; Ramamoorthi, Nandhini; Castellanos, Erick R; Balazs, Mercedesz; Xu, Min; Lee, Wyne P; Matsumoto, Marissa L; Payandeh, Jian; Arron, Joseph R; Hongo, Jo-Anne; Wang, Jianyong; Hötzel, Isidro; Austin, Cary D; Reif, Karin.

JCI Insight ; 1(7): e86689, 2016 05 19.

Artigo em Inglês | MEDLINE | ID: mdl-27699264

17.

Discovery of novel PI3-kinase Î´ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.

Safina, Brian S; Baker, Stewart; Baumgardner, Matt; Blaney, Paul M; Chan, Bryan K; Chen, Yung-Hsiang; Cartwright, Matthew W; Castanedo, Georgette; Chabot, Christine; Cheguillaume, Arnaud J; Goldsmith, Paul; Goldstein, David M; Goyal, Bindu; Hancox, Timothy; Handa, Raj K; Iyer, Pravin S; Kaur, Jasmit; Kondru, Rama; Kenny, Jane R; Krintel, Sussie L; Li, Jun; Lesnick, John; Lucas, Matthew C; Lewis, Cristina; Mukadam, Sophie; Murray, Jeremy; Nadin, Alan J; Nonomiya, Jim; Padilla, Fernando; Palmer, Wylie S; Pang, Jodie; Pegg, Neil; Price, Steve; Reif, Karin; Salphati, Laurent; Savy, Pascal A; Seward, Eileen M; Shuttleworth, Stephen; Sohal, Sukhjit; Sweeney, Zachary K; Tay, Suzanne; Tivitmahaisoon, Parcharee; Waszkowycz, Bohdan; Wei, Binqing; Yue, Qin; Zhang, Chenghong; Sutherlin, Daniel P.

J Med Chem ; 55(12): 5887-900, 2012 Jun 28.

Artigo em Inglês | MEDLINE | ID: mdl-22626259

18.

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.

Reif, Karin; Okkenhaug, Klaus; Sasaki, Takehiko; Penninger, Joseph M; Vanhaesebroeck, Bart; Cyster, Jason G.

J Immunol ; 173(4): 2236-40, 2004 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-15294934

19.

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position.

Reif, Karin; Ekland, Eric H; Ohl, Lars; Nakano, Hideki; Lipp, Martin; Förster, Reinhold; Cyster, Jason G.

Nature ; 416(6876): 94-9, 2002 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-11882900

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