1.
Bioorg Med Chem Lett
; 17(6): 1765-8, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17239592
RESUMO
A series of non-covalent inhibitors of the serine protease dipeptidyl peptidase IV (DPP-IV) were found to adopt a U-shaped binding conformation in X-ray co-crystallization studies. Remarkably, Tyr547 undergoes a 70 degrees side-chain rotation to accommodate the inhibitor and allows access to a previously unexposed area of the protein backbone for hydrogen bonding.