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Diagn Cytopathol ; 50(6): E163-E169, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35128846

RESUMO

Myoepithelial tumors (MET) constitute a group of neoplasms with a variety of morphologic, immunophenotypic, and molecular features. Approximately half of MET of soft tissue harbor EWSR1 gene rearrangements with a subset showing EWSR1-POU5F1 fusions and demonstrating distinctive tendency towards aggressive behavior in children. Histologically, EWSR1-POU5F1-positive MET typically show clear-cell morphology with malignant features including marked pleomorphism and atypical mitotic figures. The cytomorphology of these tumors has not been well characterized. Reported here are the cytomorphologic features of two cases of EWSR1-POUF1-positive MET with histology correlation.


Assuntos
Mioepitelioma , Neoplasias de Tecidos Moles , Biomarcadores Tumorais/genética , Criança , Humanos , Imunofenotipagem , Mioepitelioma/genética , Mioepitelioma/patologia , Fator 3 de Transcrição de Octâmero/genética , Proteínas de Fusão Oncogênica/genética , Proteína EWS de Ligação a RNA/genética , Neoplasias de Tecidos Moles/genética , Neoplasias de Tecidos Moles/patologia
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