Detalhe da pesquisa
1.
Species differences and human relevance of the toxicity of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors and a new approach method in vitro for investigation.
Arch Toxicol
; 97(4): 991-999, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36800004
2.
Boscalid shows increased thyroxin-glucuronidation in rat but not in human hepatocytes in vitro.
J Appl Toxicol
; 43(6): 828-844, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36549901
3.
Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis.
Int J Mol Sci
; 24(17)2023 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37686053
4.
Evaluation of human relevance of Nicofluprole-induced rat thyroid disruption.
Toxicol Appl Pharmacol
; 435: 115831, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34922950
5.
Bosentan Alters Endo- and Exogenous Bile Salt Disposition in Sandwich-Cultured Human Hepatocytes.
J Pharmacol Exp Ther
; 379(1): 20-32, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34349015
6.
Weight of evidence and human relevance evaluation of the benfluralin mode of action in rodents (Part I): Liver carcinogenesis.
Regul Toxicol Pharmacol
; 117: 104758, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32798612
7.
Weight of Evidence and Human Relevance Evaluation of the Benfluralin Mode of Action in Rats (Part II): Thyroid carcinogenesis.
Regul Toxicol Pharmacol
; 117: 104736, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32798613
8.
Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells.
Cancer Cell Int
; 18: 46, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29588626
9.
A human relevance investigation of PPARα-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in rats.
Regul Toxicol Pharmacol
; 95: 348-361, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29626562
10.
Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.
Pharm Res
; 34(6): 1309-1319, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28364304
11.
Evaluation of transcriptomic signature as a valuable tool to study drug-induced cholestasis in primary human hepatocytes.
Arch Toxicol
; 91(8): 2879-2893, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28188341
12.
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Arch Toxicol
; 91(3): 1385-1400, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27344343
13.
Hepatocyte-based in vitro model for assessment of drug-induced cholestasis.
Toxicol Appl Pharmacol
; 274(1): 124-36, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24211272
14.
Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures.
Toxicol In Vitro
; 96: 105763, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38142784
15.
Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors.
Environ Health Perspect
; 132(3): 37005, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38498338
16.
Transcriptomic hepatotoxicity signature of chlorpromazine after short- and long-term exposure in primary human sandwich cultures.
Drug Metab Dispos
; 41(10): 1835-42, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23913027
17.
Assessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy.
Xenobiotica
; 43(4): 320-35, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23153057
18.
Bupropion hydroxylation as a selective marker of rat CYP2B1 catalytic activity.
Drug Metab Dispos
; 40(1): 32-8, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21965622
19.
Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers.
Xenobiotica
; 42(10): 968-79, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22515431
20.
Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells.
FEBS Open Bio
; 12(5): 937-958, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35243817