Detalhe da pesquisa
1.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Angew Chem Int Ed Engl
; 55(33): 9601-5, 2016 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27355874
2.
Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 21(9): 2631-6, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21269825
3.
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014.
Bioorg Med Chem Lett
; 21(9): 2637-40, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21269827
4.
Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.
J Pharmacol Exp Ther
; 334(1): 269-77, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20363853
5.
Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 19(19): 5703-7, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700321
6.
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.
J Neurosci
; 27(12): 3090-7, 2007 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17376970
7.
Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models.
Biochem Pharmacol
; 75(5): 1093-103, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18076866
8.
Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.
J Pharmacol Exp Ther
; 319(2): 924-33, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16920992