Detalhe da pesquisa
1.
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.
Diabetologia
; 62(9): 1601-1615, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31203377
2.
Empagliflozin compared with glimepiride in metformin-treated patients with type 2 diabetes: 208-week data from a masked randomized controlled trial.
Diabetes Obes Metab
; 20(12): 2768-2777, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29961998
3.
Estimating the impact of changes in HbA1c, body weight and insulin injection regimen on health related quality-of-life: a time trade off study.
Health Qual Life Outcomes
; 14: 13, 2016 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26801908
4.
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.
Diabetologia
; 57(6): 1132-42, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695864
5.
Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 ß-cells accompany functional adaptations to lipotoxicity.
J Biol Chem
; 288(17): 11973-87, 2013 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23476019
6.
Personalized Intervention Based on Early Detection of Atherosclerosis: JACC State-of-the-Art Review.
J Am Coll Cardiol
; 83(21): 2112-2127, 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38777513
7.
The association of cardiometabolic, diet and lifestyle parameters with plasma glucagon-like peptide-1: An IMI DIRECT study.
J Clin Endocrinol Metab
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38686701
8.
Rationale, design and baseline characteristics of a 4-year (208-week) phase III trial of empagliflozin, an SGLT2 inhibitor, versus glimepiride as add-on to metformin in patients with type 2 diabetes mellitus with insufficient glycemic control.
Cardiovasc Diabetol
; 12: 129, 2013 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24007456
9.
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
Nat Genet
; 34(3): 267-73, 2003 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12808457
10.
Precision medicine for cardiometabolic disease: a framework for clinical translation.
Lancet Diabetes Endocrinol
; 11(11): 822-835, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37804856
11.
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.
Nat Commun
; 14(1): 5062, 2023 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37604891
12.
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study.
Cell Rep Med
; 3(1): 100477, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35106505
13.
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.
J Clin Endocrinol Metab
; 106(1): 80-90, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32944759
14.
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study.
Diabetes Care
; 44(2): 511-518, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33323478
15.
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study.
Diabetes
; 70(9): 2092-2106, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233929
16.
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.
Gastroenterology
; 137(3): 865-72, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19524579
17.
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study.
Genome Med
; 12(1): 109, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33261667
18.
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study.
PLoS One
; 15(11): e0242360, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33253307
19.
Genetic dissection of type 2 diabetes.
Mol Cell Endocrinol
; 297(1-2): 10-7, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19000735
20.
Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain.
PLoS One
; 14(9): e0222445, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31560688