Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Genomic and virulence analysis of in vitro cultured Cryptosporidium parvum.

Yarlett, Nigel; Morada, Mary; Schaefer, Deborah A; Ackman, Kevin; Carranza, Elizabeth; Baptista, Rodrigo de Paula; Riggs, Michael W; Kissinger, Jessica C.

PLoS Pathog ; 20(2): e1011992, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38416794

2.

Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis.

Hulverson, Matthew A; Choi, Ryan; Schaefer, Deborah A; Betzer, Dana P; McCloskey, Molly C; Whitman, Grant R; Huang, Wenlin; Lee, Sangun; Pranata, Andy; McLeod, Malcolm D; Marsh, Kennan C; Kempf, Dale J; LeRoy, Bruce E; Zafiratos, Mark T; Bielinski, Aimee L; Hackman, Robert C; Ojo, Kayode K; Arnold, Samuel L M; Barrett, Lynn K; Tzipori, Saul; Riggs, Michael W; Fan, Erkang; Van Voorhis, Wesley C.

Antimicrob Agents Chemother ; 67(4): e0142522, 2023 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-36920244

3.

Pharmacokinetics and Pharmacodynamics of Clofazimine for Treatment of Cryptosporidiosis.

Zhang, Cindy X; Love, Melissa S; McNamara, Case W; Chi, Victor; Woods, Ashley K; Joseph, Sean; Schaefer, Deborah A; Betzer, Dana P; Riggs, Michael W; Iroh Tam, Pui-Ying; Van Voorhis, Wesley C; Arnold, Samuel L M.

Antimicrob Agents Chemother ; 66(1): e0156021, 2022 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-34748385

4.

A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity.

O'Connor, Roberta M; Nepveux V, Felix J; Abenoja, Jaypee; Bowden, Gregory; Reis, Patricia; Beaushaw, Josiah; Bone Relat, Rachel M; Driskell, Iwona; Gimenez, Fernanda; Riggs, Michael W; Schaefer, Deborah A; Schmidt, Eric W; Lin, Zhenjian; Distel, Daniel L; Clardy, Jon; Ramadhar, Timothy R; Allred, David R; Fritz, Heather M; Rathod, Pradipsinh; Chery, Laura; White, John.

PLoS Pathog ; 16(5): e1008600, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32453775

5.

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection.

Arnold, Samuel L M; Choi, Ryan; Hulverson, Matthew A; Schaefer, Deborah A; Vinayak, Sumiti; Vidadala, Rama S R; McCloskey, Molly C; Whitman, Grant R; Huang, Wenlin; Barrett, Lynn K; Ojo, Kayode K; Fan, Erkang; Maly, Dustin J; Riggs, Michael W; Striepen, Boris; Van Voorhis, Wesley C.

J Infect Dis ; 216(1): 55-63, 2017 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-28541457

6.

Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.

Hulverson, Matthew A; Vinayak, Sumiti; Choi, Ryan; Schaefer, Deborah A; Castellanos-Gonzalez, Alejandro; Vidadala, Rama S R; Brooks, Carrie F; Herbert, Gillian T; Betzer, Dana P; Whitman, Grant R; Sparks, Hayley N; Arnold, Samuel L M; Rivas, Kasey L; Barrett, Lynn K; White, A Clinton; Maly, Dustin J; Riggs, Michael W; Striepen, Boris; Van Voorhis, Wesley C; Ojo, Kayode K.

J Infect Dis ; 215(8): 1275-1284, 2017 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-28329187

7.

5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum.

Huang, Wenlin; Choi, Ryan; Hulverson, Matthew A; Zhang, Zhongsheng; McCloskey, Molly C; Schaefer, Deborah A; Whitman, Grant R; Barrett, Lynn K; Vidadala, Rama Subba Rao; Riggs, Michael W; Maly, Dustin J; Van Voorhis, Wesley C; Ojo, Kayode K; Fan, Erkang.

Antimicrob Agents Chemother ; 61(8)2017 08.

Artigo em Inglês | MEDLINE | ID: mdl-28533246

8.

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.

Van Voorhis, Wesley C; Doggett, J Stone; Parsons, Marilyn; Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Riggs, Michael W; Hemphill, Andrew; Howe, Daniel K; Mealey, Robert H; Lau, Audrey O T; Merritt, Ethan A; Maly, Dustin J; Fan, Erkang; Ojo, Kayode K.

Exp Parasitol ; 180: 71-83, 2017 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-28065755

9.

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.

Schaefer, Deborah A; Betzer, Dana P; Smith, Kylie D; Millman, Zachary G; Michalski, Hannah C; Menchaca, Sarah E; Zambriski, Jennifer A; Ojo, Kayode K; Hulverson, Matthew A; Arnold, Samuel L M; Rivas, Kasey L; Vidadala, Rama S R; Huang, Wenlin; Barrett, Lynn K; Maly, Dustin J; Fan, Erkang; Van Voorhis, Wesley C; Riggs, Michael W.

J Infect Dis ; 214(12): 1856-1864, 2016 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-27923949

10.

The secreted effector protein EspZ is essential for virulence of rabbit enteropathogenic Escherichia coli.

Wilbur, John Scott; Byrd, Wyatt; Ramamurthy, Shylaja; Ledvina, Hannah E; Khirfan, Khaldoon; Riggs, Michael W; Boedeker, Edgar C; Vedantam, Gayatri; Viswanathan, V K.

Infect Immun ; 83(3): 1139-49, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-25561713

11.

One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases.

Van Voorhis, Wesley C; Hulverson, Matthew A; Choi, Ryan; Huang, Wenlin; Arnold, Samuel L M; Schaefer, Deborah A; Betzer, Dana P; Vidadala, Rama S R; Lee, Sangun; Whitman, Grant R; Barrett, Lynn K; Maly, Dustin J; Riggs, Michael W; Fan, Erkang; Kennedy, Thomas J; Tzipori, Saul; Doggett, J Stone; Winzer, Pablo; Anghel, Nicoleta; Imhof, Dennis; Müller, Joachim; Hemphill, Andrew; Ferre, Ignacio; Sanchez-Sanchez, Roberto; Ortega-Mora, Luis Miguel; Ojo, Kayode K.

Vet Parasitol ; 289: 109336, 2021 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-33418437

12.

Antibodies fused to innate immune molecules reduce initiation of Cryptosporidium parvum infection in mice.

Imboden, Michael; Riggs, Michael W; Schaefer, Deborah A; Homan, E Jane; Bremel, Robert D.

Antimicrob Agents Chemother ; 54(4): 1385-92, 2010 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-20086143

13.

Calf Clinical Model of Cryptosporidiosis for Efficacy Evaluation of Therapeutics.

Riggs, Michael W; Schaefer, Deborah A.

Methods Mol Biol ; 2052: 253-282, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-31452167

14.

Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells.

VanDussen, Kelli L; Funkhouser-Jones, Lisa J; Akey, Marianna E; Schaefer, Deborah A; Ackman, Kevin; Riggs, Michael W; Stappenbeck, Thaddeus S; Sibley, L David.

mBio ; 11(6)2020 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-33323514

15.

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.

Choi, Ryan; Hulverson, Matthew A; Huang, Wenlin; Vidadala, Rama S R; Whitman, Grant R; Barrett, Lynn K; Schaefer, Deborah A; Betzer, Dana P; Riggs, Michael W; Doggett, J Stone; Hemphill, Andrew; Ortega-Mora, Luis Miguel; McCloskey, Molly C; Arnold, Samuel L M; Hackman, Robert C; Marsh, Kennan C; Lynch, James J; Freiberg, Gail M; Leroy, Bruce E; Kempf, Dale J; Choy, Robert K M; de Hostos, Eugenio L; Maly, Dustin J; Fan, Erkang; Ojo, Kayode K; Van Voorhis, Wesley C.

Int J Parasitol ; 50(5): 413-422, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32224121

16.

Antigenic differences within the Cryptosporidium hominis and Cryptosporidium parvum surface proteins P23 and GP900 defined by monoclonal antibody reactivity.

Sturbaum, Gregory D; Schaefer, Deborah A; Jost, B Helen; Sterling, Charles R; Riggs, Michael W.

Mol Biochem Parasitol ; 159(2): 138-41, 2008 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-18400317

17.

Modelling Cryptosporidium infection in human small intestinal and lung organoids.

Heo, Inha; Dutta, Devanjali; Schaefer, Deborah A; Iakobachvili, Nino; Artegiani, Benedetta; Sachs, Norman; Boonekamp, Kim E; Bowden, Gregory; Hendrickx, Antoni P A; Willems, Robert J L; Peters, Peter J; Riggs, Michael W; O'Connor, Roberta; Clevers, Hans.

Nat Microbiol ; 3(7): 814-823, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29946163

18.

Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis.

Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Schaefer, Deborah A; Hemphill, Andrew; McCloskey, Molly C; Betzer, Dana P; Müller, Joachim; Vidadala, Rama S R; Whitman, Grant R; Rivas, Kasey L; Barrett, Lynn K; Hackman, Robert C; Love, Melissa S; McNamara, Case W; Shaughnessy, Thomas K; Kondratiuk, Alison; Kurnick, Matthew; Banfor, Patricia N; Lynch, James J; Freiberg, Gail M; Kempf, Dale J; Maly, Dustin J; Riggs, Michael W; Ojo, Kayode K; Van Voorhis, Wesley C.

Int J Parasitol ; 47(12): 753-763, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28899690

19.

Recent advances in cryptosporidiosis: the immune response.

Riggs, Michael W.

Microbes Infect ; 4(10): 1067-80, 2002 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-12191657

20.

Association of IL-10 expression by mucosal lymphocytes with increased expression of Cryptosporidium parvum epitopes in infected epithelium.

Wyatt, Carol R; Barrett, Wendy J; Brackett, E Joan; Schaefer, Deborah A; Riggs, Michael W.

J Parasitol ; 88(2): 281-6, 2002 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-12053998

BVS Doenças Infecciosas e Parasitárias

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: