pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions.

Detailed annotation of an IncHI2 plasmid, pSTM6-275, from Salmonella enterica serotype 1,4,5,12:i:- strain TW-Stm6 revealed a composite structure, including antimicrobial resistance genes on mobile genetic elements. The plasmid was thermosensitive for transfer to Escherichia coli and conferred reduced susceptibility to antibiotics, copper sulfate, and silver nitrate. Metal ion susceptibility was dependent on physiological conditions, giving an insight into the environments where this trait might confer a fitness advantage.

Synchronous cancers of gallbladder carcinoma and combined hepatocellular cholangiocarcinoma: an unusual case and literature review.

BACKGROUND: Synchronous primary cancers in gallbladder and liver are rarely reported. Here we report an unusual case of synchronous cancers of gallbladder carcinoma and combined hepatocellular cholangiocarcinoma. CASE PRESENTATION: Several lesions in the gallbladder and in adjacent parenchyma of liver were discovered in a 65-years-old woman by imaging examination. Surgical resection was performed following a diagnosis of primary gallbladder carcinoma with local hepatic metastasis. Histological examination confirmed the diagnosis of primary gallbladder carcinoma, and the lesions in the liver consisted of hepatocellular carcinoma simultaneously with cholangiocarcinoma. Adjuvant chemoradiation therapy was not performed due to the patient's refusal of the treatment. Unfortunately, the patient died of widespread metastasis 8 months after the operation. CONCLUSIONS: The disease needed to be differentially diagnosed from gallbladder carcinoma with hepatic metastasis. Aggressive surgical approach should be based on a balance between the risk of surgery (morbidity and mortality) and the outcome.

Idealised media images: The effect of fitspiration imagery on body satisfaction and exercise behaviour.

Recent studies have documented a shift in the cultural ideal of physical attractiveness, with women subscribing to a visibly toned ideal that emphasises health and fitness. The present study experimentally investigated the impact of athletic and muscular fitness-idealised images compared to traditional thin ideal images on women's body dissatisfaction and exercise behaviour, under the framework of Social Comparison Theory. Participants were 106 female undergraduate students randomly assigned to view one of three sets of images (thin ideal, athletic ideal, or muscular ideal) followed by a bout of exercise. Acute exposure to athletic ideal and thin ideal images led to increased body dissatisfaction, but exposure to muscular ideal images did not. Relative to thin ideal images, fitness-idealised images did not motivate participants to engage in higher levels of exercise suggesting that this type of fitness inspiration might not motivate actual exercise behaviour.