Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL.

Lee, Jung Wha; Huang, Jiahn-Dar; Rodriguez, Ignacio R.

Biochim Biophys Acta ; 1851(5): 605-19, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25617738

2.

Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina.

Wang, Minhua; Wang, Xu; Zhao, Lian; Ma, Wenxin; Rodriguez, Ignacio R; Fariss, Robert N; Wong, Wai T.

J Neurosci ; 34(10): 3793-806, 2014 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-24599476

3.

7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen.

Rodriguez, Ignacio R; Clark, Mark E; Lee, Jung Wha; Curcio, Christine A.

Exp Eye Res ; 128: 151-5, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25261634

4.

Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization.

Huang, Jiahn-Dar; Amaral, Juan; Lee, Jung Wha; Larrayoz, Ignacio M; Rodriguez, Ignacio R.

Biochim Biophys Acta ; 1821(4): 637-46, 2012 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-22342272

5.

Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice.

Friedman, James S; Chang, Bo; Krauth, Daniel S; Lopez, Irma; Waseem, Naushin H; Hurd, Ron E; Feathers, Kecia L; Branham, Kari E; Shaw, Manessa; Thomas, George E; Brooks, Matthew J; Liu, Chunqiao; Bakeri, Hirva A; Campos, Maria M; Maubaret, Cecilia; Webster, Andrew R; Rodriguez, Ignacio R; Thompson, Debra A; Bhattacharya, Shomi S; Koenekoop, Robert K; Heckenlively, John R; Swaroop, Anand.

Proc Natl Acad Sci U S A ; 107(35): 15523-8, 2010 Aug 31.

Artigo em Inglês | MEDLINE | ID: mdl-20713727

6.

Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration.

Rodríguez, Ignacio R; Larrayoz, Ignacio M.

J Lipid Res ; 51(10): 2847-62, 2010 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-20567027

7.

Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage.

Pascual, Iranzu; Larrayoz, Ignacio M; Campos, Maria M; Rodriguez, Ignacio R.

Exp Eye Res ; 90(3): 420-8, 2010 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-20026324

8.

Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters.

Pascual, Iranzu; Larrayoz, Ignacio M; Rodriguez, Ignacio R.

Genomics ; 93(1): 62-71, 2009 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-18845237

9.

Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism.

Rodriguez, Ignacio R; Fliesler, Steven J.

Photochem Photobiol ; 85(5): 1116-25, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19500292

10.

Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity.

Ikeuchi, Tomoko; de Vega, Susana; Forcinito, Patricia; Doyle, Andrew D; Amaral, Juan; Rodriguez, Ignacio R; Arikawa-Hirasawa, Eri; Yamada, Yoshihiko.

Sci Rep ; 8(1): 17654, 2018 12 05.

Artigo em Inglês | MEDLINE | ID: mdl-30518776

11.

Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors.

Tserentsoodol, Nomingerel; Gordiyenko, Natalyia V; Pascual, Iranzu; Lee, Jung Wha; Fliesler, Steven J; Rodriguez, Ignacio R.

Mol Vis ; 12: 1319-33, 2006 Oct 27.

Artigo em Inglês | MEDLINE | ID: mdl-17110915

12.

Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated process.

Tserentsoodol, Nomingerel; Sztein, Jorge; Campos, Mercedes; Gordiyenko, Natalya V; Fariss, Robert N; Lee, Jung Wha; Fliesler, Steven J; Rodriguez, Ignacio R.

Mol Vis ; 12: 1306-18, 2006 Oct 27.

Artigo em Inglês | MEDLINE | ID: mdl-17110914

13.

7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration.

Indaram, Maanasa; Ma, Wenxin; Zhao, Lian; Fariss, Robert N; Rodriguez, Ignacio R; Wong, Wai T.

Sci Rep ; 5: 9144, 2015 Mar 16.

Artigo em Inglês | MEDLINE | ID: mdl-25775051

14.

Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1ß and IL-18.

Shi, Guangpu; Chen, Siqi; Wandu, Wambui S; Ogbeifun, Osato; Nugent, Lindsey F; Maminishkis, Arvydas; Hinshaw, Samuel J H; Rodriguez, Ignacio R; Gery, Igal.

Invest Ophthalmol Vis Sci ; 56(3): 1658-64, 2015 Feb 12.

Artigo em Inglês | MEDLINE | ID: mdl-25678688

15.

Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol.

Rodriguez, Ignacio R; Alam, Shahabuddin; Lee, Jung Wha.

Invest Ophthalmol Vis Sci ; 45(8): 2830-7, 2004 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-15277510

16.

RPE cells internalize low-density lipoprotein (LDL) and oxidized LDL (oxLDL) in large quantities in vitro and in vivo.

Gordiyenko, Nataliya; Campos, Maria; Lee, Jung Wha; Fariss, Robert N; Sztein, Jorge; Rodriguez, Ignacio R.

Invest Ophthalmol Vis Sci ; 45(8): 2822-9, 2004 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-15277509

17.

7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.

Huang, Jiahn-Dar; Amaral, Juan; Lee, Jung Wha; Rodriguez, Ignacio R.

PLoS One ; 9(7): e100985, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25036103

18.

7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model.

Amaral, Juan; Lee, Jung Wha; Chou, Joshua; Campos, Maria M; Rodríguez, Ignacio R.

PLoS One ; 8(2): e56099, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23409131

19.

7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation.

Larrayoz, Ignacio M; Huang, Jiahn-Dar; Lee, Jung Wha; Pascual, Iranzu; Rodríguez, Ignacio R.

Invest Ophthalmol Vis Sci ; 51(10): 4942-55, 2010 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-20554621

20.

Rapid analysis of oxysterols by HPLC and UV spectroscopy.

Rodriguez, Ignacio R.

Biotechniques ; 36(6): 952-4, 956, 958, 2004 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-15211745

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