Fundamental behavioral and neurophysiologic relationships between sensory processing, intolerance of uncertainty, and autistic traits in children: A hybrid approach.

Sensory differences are common and often challenging for autistic children. Furthermore, atypical sensory processing is associated with autistic traits and other autism-related behaviors, such as intolerance of uncertainty (IU). Such traits and their relatedness vary continuously across autistic and non-autistic children alike. However, the underlying neural correlates of these continuous variables, and their associations, are not well understood. Therefore, this study examined relationships between sensory processing, IU, autistic traits, and associated resting state brain connectivity, across a sample of both autistic (n = 30) and non-autistic (n = 26) children. In addition to computing behavioral correlations between these factors, we carried out independent component network functional connectivity analysis to investigate associations between cortical and cerebellar networks and behavioral results between groups and across our entire sample. Across-group correlations between sensory processing, autistic traits, and IU were significant. In addition, data demonstrated overlapping sensory processing and intolerance of uncertainty scores, spanning the groups. Brain (rs-fMRI)-behavioral relationships revealed strong associations between sensory, large-scale resting state, and cerebellar networks and behavioral scores. Overall, our findings suggest that sensory differences are related to IU and autistic traits across the population. Neurophysiologic data pointed to functional connectivity between sensory cortices and supramodal brain networks. These findings provide evidence for the continuous variation of behaviors common to autism throughout the entire population and their neurobiological correlates.

Spacious Environments Make Us Tolerant-The Role of Emotion and Metaphor.

The physical environment plays an important role in moral cognition. Previous research has demonstrated that the physical environment affects individual moral judgment. Investigators have argued that the environment influences moral judgment through emotion and cognition, such as during metaphor processing. Following the intensification of urbanization and increases in population size, the phenomenon of a narrow environment has become more common. However, the relation between environmental spaciousness and moral judgment has not been thoroughly examined. We examined the effect of environmental spaciousness (spaciousness vs. narrowness) on moral judgments in Experiment 1 and Experiment 2. Results showed that participants report a higher rating score of moral judgment in more spacious environments compared with narrow environments. We further explored the roles of emotion and metaphor in the relation between environmental spaciousness and moral judgments. We found support for a partial mediation effect of emotion in the relationship between environmental spaciousness and moral judgment. The results also supported an association between the concept of spaciousness and tolerant cognition. Spacious environments may elicit positive emotions and more tolerant cognition, which in turn influences moral judgment. These results provide new evidence for the influence of the environment on moral judgments, and more attention may be warranted to incorporate this relationship in environmental design.

Residual effects of cannabis use on attentional bias towards fearful faces.

Cannabis use has increased since legalization in various states within the United States of America. Although much of the research on the neurological and psychological effects of cannabis has been on non-human animals, the current research suggests that it can have anxiolytic effects and also decrease some cognitive functioning (e.g. memory, emotional processing, etc.). Individuals with high anxiety have been suggested to have increased attentional bias towards threat-related stimuli. The current study measured event-related potential (ERP) during a dot-probe task with fearful and neutral facial expression to examine the residual effects of cannabis use on attentional bias. The results indicated that there was reduced attentional bias, as measured by the P1 component in cannabis users, which is similar to low anxious individuals. Additionally, there was no difference between users and non-users in N170, indicating that the residual effects of cannabis did not interfere with face processing. However, an exploratory correlation indicated that higher cannabis use was associated with reduced N170 towards fearful faces. Cannabis use was associated with enhanced N2pc, which would indicate greater spatial orientation of attention. These results suggest that cannabis use did have an effect on attentional bias towards fearful faces.

Imaging decision about whether to benefit self by harming others: Adolescents with conduct and substance problems, with or without callous-unemotionality, or developing typically.

We sought to identify brain activation differences in conduct-problem youth with limited prosocial emotions (LPE) compared to conduct-problem youth without LPE and community adolescents, and to test associations between brain activation and severity of callous-unemotional traits. We utilized a novel task, which asks subjects to repeatedly decide whether to accept offers where they will benefit but a beneficent other will be harmed. Behavior on this task has been previously associated with levels of prosocial emotions and severity of callous-unemotional traits, and is related to empathic concern. During fMRI acquisition, 66 male adolescents (21 conduct-problem patients with LPE, 21 without, and 24 typically-developing controls) played this novel game. Within typically-developing controls, we identified a network engaged during decision involving bilateral insula, and inferior parietal and medial frontal cortices, among other regions. Group comparisons using non-parametric (distribution-free) permutation tests demonstrated LPE patients had lower activation estimates than typically-developing adolescents in right anterior insula. Additional significant group differences emerged with our a priori parametric cluster-wise inference threshold. These results suggest measurable functional brain activation differences in conduct-problem adolescents with LPE compared to typically-developing adolescents. Such differences may underscore differential treatment needs for conduct-problem males with and without LPE.

Free will, determinism, and punishment.

Determinists were compared with weak, moderate, and strong libertarians with respect to philosophy of punishment. Data provided support for the contention that determinists are less punitive than libertarians.