Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Basic science under threat: Lessons from the Skirball Institute.

Sfeir, Agnel; Fishell, Gord; Schier, Alexander F; Dustin, Michael L; Gan, Wen-Biao; Joyner, Alexandra; Lehmann, Ruth; Ron, David; Roth, David; Talbot, William S; Yelon, Deborah; Zychlinsky, Arturo.

Cell ; 185(5): 755-758, 2022 03 03.

Artigo em Inglês | MEDLINE | ID: mdl-35245477

2.

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.

Amin-Wetzel, Niko; Saunders, Reuben A; Kamphuis, Maarten J; Rato, Claudia; Preissler, Steffen; Harding, Heather P; Ron, David.

Cell ; 171(7): 1625-1637.e13, 2017 Dec 14.

Artigo em Inglês | MEDLINE | ID: mdl-29198525

3.

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.

Zyryanova, Alisa F; Kashiwagi, Kazuhiro; Rato, Claudia; Harding, Heather P; Crespillo-Casado, Ana; Perera, Luke A; Sakamoto, Ayako; Nishimoto, Madoka; Yonemochi, Mayumi; Shirouzu, Mikako; Ito, Takuhiro; Ron, David.

Mol Cell ; 81(1): 88-103.e6, 2021 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-33220178

4.

The IRE1ß-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells.

Neidhardt, Lisa; Cloots, Eva; Friemel, Natalie; Weiss, Caroline A M; Harding, Heather P; McLaughlin, Stephen H; Janssens, Sophie; Ron, David.

EMBO J ; 43(5): 719-753, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38177498

5.

Substrate recruitment via eIF2Î³ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.

Yan, Yahui; Shetty, Maithili; Harding, Heather P; George, Ginto; Zyryanova, Alisa; Labbé, Katherine; Mafi, Amirhossein; Hao, Qi; Sidrauski, Carmela; Ron, David.

Proc Natl Acad Sci U S A ; 121(14): e2320013121, 2024 Apr 02.

Artigo em Inglês | MEDLINE | ID: mdl-38547060

6.

Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.

Coll, Anthony P; Chen, Michael; Taskar, Pranali; Rimmington, Debra; Patel, Satish; Tadross, John A; Cimino, Irene; Yang, Ming; Welsh, Paul; Virtue, Samuel; Goldspink, Deborah A; Miedzybrodzka, Emily L; Konopka, Adam R; Esponda, Raul Ruiz; Huang, Jeffrey T-J; Tung, Y C Loraine; Rodriguez-Cuenca, Sergio; Tomaz, Rute A; Harding, Heather P; Melvin, Audrey; Yeo, Giles S H; Preiss, David; Vidal-Puig, Antonio; Vallier, Ludovic; Nair, K Sreekumaran; Wareham, Nicholas J; Ron, David; Gribble, Fiona M; Reimann, Frank; Sattar, Naveed; Savage, David B; Allan, Bernard B; O'Rahilly, Stephen.

Nature ; 578(7796): E24, 2020 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-32051582

7.

GDF15 mediates the effects of metformin on body weight and energy balance.

Coll, Anthony P; Chen, Michael; Taskar, Pranali; Rimmington, Debra; Patel, Satish; Tadross, John A; Cimino, Irene; Yang, Ming; Welsh, Paul; Virtue, Samuel; Goldspink, Deborah A; Miedzybrodzka, Emily L; Konopka, Adam R; Esponda, Raul Ruiz; Huang, Jeffrey T-J; Tung, Y C Loraine; Rodriguez-Cuenca, Sergio; Tomaz, Rute A; Harding, Heather P; Melvin, Audrey; Yeo, Giles S H; Preiss, David; Vidal-Puig, Antonio; Vallier, Ludovic; Nair, K Sreekumaran; Wareham, Nicholas J; Ron, David; Gribble, Fiona M; Reimann, Frank; Sattar, Naveed; Savage, David B; Allan, Bernard B; O'Rahilly, Stephen.

Nature ; 578(7795): 444-448, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31875646

8.

An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.

Perera, Luke A; Rato, Claudia; Yan, Yahui; Neidhardt, Lisa; McLaughlin, Stephen H; Read, Randy J; Preissler, Steffen; Ron, David.

EMBO J ; 38(21): e102177, 2019 10 04.

Artigo em Inglês | MEDLINE | ID: mdl-31531998

9.

Diabetes, insulin and new therapeutic strategies for Parkinson's disease: Focus on glucagon-like peptide-1 receptor agonists.

Labandeira, Carmen M; Fraga-Bau, Arturo; Arias Ron, David; Muñoz, Ana; Alonso-Losada, Gema; Koukoulis, Antonio; Romero-Lopez, Jesus; Rodriguez-Perez, Ana I.

Front Neuroendocrinol ; 62: 100914, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-33845041

10.

Effect of antiangiogenic-based treatment and systemic inflammatory factors on outcomes in patients with BRAF v600-mutated metastatic colorectal cancer: a real-world study in Spain.

Martínez-Lago, Nieves; Fernández-Montes, Ana; Covela, Marta; Brozos, Elena M; De la Cámara, Juan; Méndez Méndez, José C; Jorge-Fernández, Mónica; Cousillas Castiñeiras, Antía; Reboredo, Cristina; Arias Ron, David; Pellón Augusto, María L; González Villarroel, Paula; Graña, Begoña; Salgado Fernández, Mercedes; Carral Maseda, Alberto; Vázquez Rivera, Francisca; Candamio Folgar, Sonia; Reboredo López, Margarita.

BMC Cancer ; 21(1): 64, 2021 Jan 14.

Artigo em Inglês | MEDLINE | ID: mdl-33446148

11.

SnapShot: The unfolded protein response.

Wiseman, R Luke; Haynes, Cole M; Ron, David.

Cell ; 140(4): 590-590.e2, 2010 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-20178750

12.

Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice.

Zito, Ester; Hansen, Henning Gram; Yeo, Giles S H; Fujii, Junichi; Ron, David.

Mol Cell ; 48(1): 39-51, 2012 Oct 12.

Artigo em Inglês | MEDLINE | ID: mdl-22981861

13.

A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α.

Crespillo-Casado, Ana; Claes, Zander; Choy, Meng S; Peti, Wolfgang; Bollen, Mathieu; Ron, David.

J Biol Chem ; 293(20): 7766-7776, 2018 05 18.

Artigo em Inglês | MEDLINE | ID: mdl-29618508

14.

The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.

Huang, Huai-Wei; Zeng, Xiaomei; Rhim, Taiyoun; Ron, David; Ryoo, Hyung Don.

J Cell Sci ; 130(18): 3040-3049, 2017 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-28775151

15.

Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin.

Zito, Ester; Melo, Eduardo Pinho; Yang, Yun; Wahlander, Åsa; Neubert, Thomas A; Ron, David.

Mol Cell ; 40(5): 787-97, 2010 Dec 10.

Artigo em Inglês | MEDLINE | ID: mdl-21145486

16.

The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.

Haynes, Cole M; Yang, Yun; Blais, Steven P; Neubert, Thomas A; Ron, David.

Mol Cell ; 37(4): 529-40, 2010 Feb 26.

Artigo em Inglês | MEDLINE | ID: mdl-20188671

17.

Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.

Wiseman, R Luke; Zhang, Yuhong; Lee, Kenneth P K; Harding, Heather P; Haynes, Cole M; Price, Joshua; Sicheri, Frank; Ron, David.

Mol Cell ; 38(2): 291-304, 2010 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-20417606

18.

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H₂O₂.

Melo, Eduardo Pinho; Lopes, Carlos; Gollwitzer, Peter; Lortz, Stephan; Lenzen, Sigurd; Mehmeti, Ilir; Kaminski, Clemens F; Ron, David; Avezov, Edward.

BMC Biol ; 15(1): 24, 2017 03 27.

Artigo em Inglês | MEDLINE | ID: mdl-28347335

19.

PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis.

Ho, Yeung; Li, Xiting; Jamison, Stephanie; Harding, Heather P; McKinnon, Peter J; Ron, David; Lin, Wensheng.

Am J Pathol ; 186(7): 1939-1951, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27181404

20.

Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism.

Miyake, Masato; Nomura, Akitoshi; Ogura, Atsushi; Takehana, Kenji; Kitahara, Yoshihiro; Takahara, Kazuna; Tsugawa, Kazue; Miyamoto, Chinobu; Miura, Naoko; Sato, Ryosuke; Kurahashi, Kiyoe; Harding, Heather P; Oyadomari, Miho; Ron, David; Oyadomari, Seiichi.

FASEB J ; 30(2): 798-812, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26487695

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