Detalhe da pesquisa
1.
The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.
Bioorg Med Chem Lett
; 41: 127973, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753261
2.
Late-Stage Functionalization by Chan-Lam Amination: Rapid Access to Potent and Selective Integrin Inhibitors.
Chemistry
; 26(34): 7678-7684, 2020 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32129907
3.
The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists.
Bioorg Med Chem Lett
; 26(24): 5855-5859, 2016 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27866818
4.
A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1.
SLAS Discov
; 28(1): 3-11, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36414185
5.
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
J Med Chem
; 64(18): 13780-13792, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34510892
6.
Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin.
EMBO Mol Med
; 13(3): e13167, 2021 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33512066
7.
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.
Bioorg Med Chem Lett
; 20(15): 4683-8, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20566291
8.
Discovery of the first potent and selective αvß5 integrin inhibitor based on an amide-containing core.
Eur J Med Chem
; 208: 112719, 2020 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32865176
9.
Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase δ.
ACS Med Chem Lett
; 11(7): 1386-1391, 2020 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32676144
10.
Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target.
J Med Chem
; 63(2): 638-655, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31855425
11.
The Design of Potent, Selective and Drug-Like RGD αvß1 Small-Molecule Inhibitors Derived from non-RGD α4ß1 Antagonists.
ChemMedChem
; 14(14): 1315-1320, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31207080
12.
Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.
J Med Chem
; 62(19): 8796-8808, 2019 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31497959
13.
Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvß6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.
J Med Chem
; 62(16): 7543-7556, 2019 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31381331
14.
Free-Wilson Analysis of Comprehensive Data on Phosphoinositide-3-kinase (PI3K) Inhibitors Reveals Importance of N-Methylation for PI3Kδ Activity.
J Med Chem
; 62(22): 10402-10422, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31647659
15.
Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach.
J Med Chem
; 61(24): 11061-11073, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30532965
16.
Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvß6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 61(18): 8417-8443, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30215258
17.
Determining the True Selectivity Profile of αv Integrin Ligands Using Radioligand Binding: Applying an Old Solution to a New Problem.
SLAS Discov
; 22(8): 962-973, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28414923
18.
Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis.
ACS Med Chem Lett
; 8(5): 577-581, 2017 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28523114
19.
Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ) Inhibitors.
J Med Chem
; 60(4): 1534-1554, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28128944
20.
Relative binding affinities of integrin antagonists by equilibrium dialysis and liquid chromatography-mass spectrometry.
ACS Med Chem Lett
; 6(2): 221-4, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25699153