Detalhe da pesquisa
1.
Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block ß-amyloid aggregation.
Arch Pharm (Weinheim)
; 357(2): e2300447, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38072670
2.
Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease.
Molecules
; 29(2)2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38257233
3.
Rapid Pacing Decreases L-type Ca2+ Current and Alters Cacna1c Isogene Expression in Primary Cultured Rat Left Ventricular Myocytes.
J Membr Biol
; 256(3): 257-269, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36995425
4.
Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease.
Int J Mol Sci
; 24(3)2023 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36768608
5.
Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease.
Int J Mol Sci
; 23(22)2022 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430413
6.
Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile.
Molecules
; 27(3)2022 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35164325
7.
Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity.
Molecules
; 27(22)2022 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36431823
8.
Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals.
Molecules
; 28(1)2022 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36615256
9.
Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment.
Bioorg Chem
; 112: 104974, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34029971
10.
Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands.
Molecules
; 26(18)2021 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34576998
11.
Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation.
Bioorg Chem
; 94: 103387, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31735356
12.
New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment.
Molecules
; 25(17)2020 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32867324
13.
New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment.
Molecules
; 25(24)2020 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33322783
14.
Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
Bioorg Med Chem Lett
; 29(23): 126716, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31640885
15.
Synthesis, molecular docking, and biological evaluation of 3-oxo-2-tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors.
Bioorg Chem
; 91: 103097, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31323527
16.
Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.
Bioorg Med Chem
; 26(16): 4716-4725, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104121
17.
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.
Bioorg Med Chem
; 25(21): 5981-5994, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28986116
18.
Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.
Bioorg Med Chem
; 25(15): 3997-4007, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28578994
19.
Neuropathy target esterase in mouse whole blood as a biomarker of exposure to neuropathic organophosphorus compounds.
J Appl Toxicol
; 36(11): 1468-75, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26970094
20.
Localization of Kv4.2 and KChIP2 in lipid rafts and modulation of outward K+ currents by membrane cholesterol content in rat left ventricular myocytes.
Pflugers Arch
; 467(2): 299-309, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24793047