Detalhe da pesquisa
1.
Electrochemical Synthesis of a Sitagliptin Precursor.
J Org Chem
; 2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38655880
2.
Single step synthesis of ß- and γ- aryl-substituted ß- and γ-amino acid derivatives by electrochemistry.
Bioorg Med Chem Lett
; 100: 129614, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38199329
3.
Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
J Biol Chem
; 295(36): 12605-12617, 2020 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32647007
4.
Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney.
NMR Biomed
; 34(11): e4583, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34240478
5.
Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders.
Molecules
; 26(4)2021 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33668468
6.
Photoredox-Mediated Hydrogen Isotope Exchange Reactions of Amino-Acids, Peptides, and Peptide-Derived Drugs.
Chemistry
; 26(56): 12738-12742, 2020 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32716576
7.
Using Graph Databases to Investigate Trends in Structure-Activity Relationship Networks.
J Chem Inf Model
; 60(12): 6120-6134, 2020 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33245234
8.
Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity.
Amino Acids
; 51(1): 7-16, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29922921
9.
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.
Bioorg Med Chem Lett
; 28(5): 922-925, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29433927
10.
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
Biochem Biophys Res Commun
; 491(2): 416-422, 2017 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28720493
11.
Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.
J Biol Chem
; 290(47): 28446-28455, 2015 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26459563
12.
Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels.
J Transl Med
; 14(1): 153, 2016 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27246731
13.
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.
Biochem Biophys Res Commun
; 445(2): 451-6, 2014 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24530914
14.
Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Sci Rep
; 12(1): 15440, 2022 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36104373
15.
A Solid Supported Membrane-Based Technology for Electrophysical Screening of B0AT1-Modulating Compounds.
SLAS Discov
; 26(6): 783-797, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33955247
16.
The PROTACtable genome.
Nat Rev Drug Discov
; 20(10): 789-797, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34285415
17.
Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers.
Chem Sci
; 11(23): 6053-6057, 2020 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34094098
18.
Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion.
JACC Basic Transl Sci
; 4(3): 332-344, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-31312757
19.
A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Sci Rep
; 8(1): 3660, 2018 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29483571
20.
Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects.
Clin Pharmacol Drug Dev
; 5(1): 57-68, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27119579