RESUMO
The authors studied the expression of CD1 and HLA-Dr antigen in benign and malignant melanic tumors to known if were the melanoma's cells or Langerhans cells, presents on the tumor, which exhibited the HLA-Dr antigens, and if the HLA-Dr expression was related to volume, depth and metastatic characteristics. These antigens were studied with the monoclonal antibodies labelled to avidin-biotin-peroxidase system. The results shows than the proportion between the number of Langerhans cells and HLA-Dr positive cells is inverse. No differences were found between the expression of the HLA-Dr antigens and number of Langerhans cells and volume, depth or metastatic characteristics.
Assuntos
Antígenos de Diferenciação/análise , Antígenos HLA-DR/análise , Células de Langerhans/patologia , Melanoma/imunologia , Nevo Pigmentado/imunologia , Neoplasias Cutâneas/imunologia , Antígenos CD1 , Humanos , Melanoma/patologia , Nevo Pigmentado/patologia , Neoplasias Cutâneas/patologiaRESUMO
The authors studied human epidermal differentiation in normal skin and skin cultured according to Green's method. No differences was observed except for the filaggrin and involucrin patterns; the lectins revealed identical patterns in normal and cultured human epidermis. The ultrastructural study verified a similar morphology in both types of epidermis.