Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma.

Craig, Amanda J; Garcia-Lezana, Teresa; Ruiz de Galarreta, Marina; Villacorta-Martin, Carlos; Kozlova, Edgar G; Martins-Filho, Sebastiao N; von Felden, Johann; Ahsen, Mehmet Eren; Bresnahan, Erin; Hernandez-Meza, Gabriela; Labgaa, Ismail; D'Avola, Delia; Schwartz, Myron; Llovet, Josep M; Sia, Daniela; Thung, Swan; Losic, Bojan; Lujambio, Amaia; Villanueva, Augusto.

PLoS Genet ; 17(6): e1009589, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-34166362

2.

Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma.

Molina-Sánchez, Pedro; Ruiz de Galarreta, Marina; Yao, Melissa A; Lindblad, Katherine E; Bresnahan, Erin; Bitterman, Elizabeth; Martin, Tiphaine C; Rubenstein, Troy; Nie, Kai; Golas, Jonathan; Choudhary, Shambhunath; Bárcena-Varela, Marina; Elmas, Abdulkadir; Miguela, Veronica; Ding, Ying; Kan, Zhengyan; Grinspan, Lauren Tal; Huang, Kuan-Lin; Parsons, Ramon E; Shields, David J; Rollins, Robert A; Lujambio, Amaia.

Gastroenterology ; 159(6): 2203-2220.e14, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-32814112

3.

Cell type-specific pharmacological kinase inhibition for cancer chemoprevention.

Deshmukh, Manjeet; Nakagawa, Shigeki; Higashi, Takaaki; Vincek, Adam; Venkatesh, Anu; Ruiz de Galarreta, Marina; Koh, Anna P; Goossens, Nicolas; Hirschfield, Hadassa; Bian, C Billie; Fujiwara, Naoto; Ono, Atsushi; Hoshida, Hiroki; El-Abtah, Mohamed; Ahmad, Noor B; Lujambio, Amaia; Sanchez, Roberto; Fuchs, Bryan C; Poelstra, Klaas; Prakash, Jai; Hoshida, Yujin.

Nanomedicine ; 14(2): 317-325, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29157977

4.

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma.

Bollard, Julien; Miguela, Verónica; Ruiz de Galarreta, Marina; Venkatesh, Anu; Bian, C Billie; Roberto, Mark P; Tovar, Victoria; Sia, Daniela; Molina-Sánchez, Pedro; Nguyen, Christie B; Nakagawa, Shigeki; Llovet, Josep M; Hoshida, Yujin; Lujambio, Amaia.

Gut ; 66(7): 1286-1296, 2017 07.

Artigo em Inglês | MEDLINE | ID: mdl-27849562

5.

Therapeutic editing of hepatocyte genome in vivo.

Ruiz de Galarreta, Marina; Lujambio, Amaia.

J Hepatol ; 67(4): 818-828, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28527665

6.

Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis.

Magdaleno, Fernando; Arriazu, Elena; Ruiz de Galarreta, Marina; Chen, Yu; Ge, Xiaodong; Conde de la Rosa, Laura; Nieto, Natalia.

J Hepatol ; 65(5): 963-971, 2016 11.

Artigo em Inglês | MEDLINE | ID: mdl-27318326

7.

Fibronectin peptides as potential regulators of hepatic fibrosis through apoptosis of hepatic stellate cells.

Mòdol, Teresa; Brice, Natalia; Ruiz de Galarreta, Marina; García Garzón, Antonia; Iraburu, María J; Martínez-Irujo, Juan J; López-Zabalza, María J.

J Cell Physiol ; 230(3): 546-53, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24976518

8.

Hepatocellular carcinoma: killing one bird with two stones.

Ruiz de Galarreta, Marina; Lujambio, Amaia.

Gut ; 68(9): 1543-1544, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31076399

9.

GCN2 kinase is a key regulator of fibrogenesis and acute and chronic liver injury induced by carbon tetrachloride in mice.

Arriazu, Elena; Ruiz de Galarreta, Marina; López-Zabalza, María J; Leung, Tung Ming; Nieto, Natalia; Iraburu, María J.

Lab Invest ; 93(3): 303-10, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23318883

10.

Antifibrogenic and apoptotic effects of Ocoxin in cultured rat hepatic stellate cells.

Ruiz de Galarreta, Marina; Arriazu, Elena; Pérez de Obanos, María P; Ansorena, Eduardo; Iraburu, María J.

J Physiol Biochem ; 79(4): 881-890, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-35239161

11.

WNTinib is a multi-kinase inhibitor with specificity against ß-catenin mutant hepatocellular carcinoma.

Rialdi, Alex; Duffy, Mary; Scopton, Alex P; Fonseca, Frank; Zhao, Julia Nanyi; Schwarz, Megan; Molina-Sanchez, Pedro; Mzoughi, Slim; Arceci, Elisa; Abril-Fornaguera, Jordi; Meadows, Austin; Ruiz de Galarreta, Marina; Torre, Denis; Reyes, Kyna; Lim, Yan Ting; Rosemann, Felix; Khan, Zaigham M; Mohammed, Kevin; Wang, Xuedi; Yu, Xufen; Lakshmanan, Manikandan; Rajarethinam, Ravisankar; Tan, Soo Yong; Jin, Jian; Villanueva, Augusto; Michailidis, Eleftherios; De Jong, Ype P; Rice, Charles M; Marazzi, Ivan; Hasson, Dan; Llovet, Josep M; Sobota, Radoslaw M; Lujambio, Amaia; Guccione, Ernesto; Dar, Arvin C.

Nat Cancer ; 4(8): 1157-1175, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37537299

12.

Manipulating and tracking single hepatocyte behavior during mouse liver regeneration by performing hydrodynamic tail vein injection.

Wang, Shuang; Ruiz de Galarreta, Marina; Sadler, Kirsten C; Lujambio, Amaia.

STAR Protoc ; 2(2): 100440, 2021 06 18.

Artigo em Inglês | MEDLINE | ID: mdl-33899021

13.

Tumor-Intrinsic Mechanisms Regulating Immune Exclusion in Liver Cancers.

Lindblad, Katherine E; Ruiz de Galarreta, Marina; Lujambio, Amaia.

Front Immunol ; 12: 642958, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33981303

14.

Mouse Models of Oncoimmunology in Hepatocellular Carcinoma.

Bresnahan, Erin; Lindblad, Katherine E; Ruiz de Galarreta, Marina; Lujambio, Amaia.

Clin Cancer Res ; 26(20): 5276-5286, 2020 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-32327473

15.

Cold-Inducible RNA Binding Protein as a Vaccination Platform to Enhance Immunotherapeutic Responses Against Hepatocellular Carcinoma.

Silva, Leyre; Egea, Josune; Villanueva, Lorea; Ruiz, Marta; Llopiz, Diana; Repáraz, David; Aparicio, Belén; Lasarte-Cia, Aritz; Lasarte, Juan José; Ruiz de Galarreta, Marina; Lujambio, Amaia; Sangro, Bruno; Sarobe, Pablo.

Cancers (Basel) ; 12(11)2020 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-33207844

16.

Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology.

Yu, Jia Xin; Craig, Amanda J; Duffy, Mary E; Villacorta-Martin, Carlos; Miguela, Verónica; Ruiz de Galarreta, Marina; Scopton, Alexander P; Silber, Lisa; Maldonado, Andres Y; Rialdi, Alexander; Guccione, Ernesto; Lujambio, Amaia; Villanueva, Augusto; Dar, Arvin C.

Mol Cancer Ther ; 18(9): 1506-1519, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31213506

17.

Genetic Modification of CD8⁺ T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies.

Lozano, Teresa; Chocarro, Silvia; Martin, Celia; Lasarte-Cia, Aritz; Del Valle, Cynthia; Gorraiz, Marta; Sarrión, Patricia; Ruiz de Galarreta, Marina; Lujambio, Amaia; Hervás-Stubbs, Sandra; Sarobe, Pablo; Casares, Noelia; Lasarte, Juan J.

Front Immunol ; 10: 2990, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31921216

18.

ß-Catenin Activation Promotes Immune Escape and Resistance to Anti-PD-1 Therapy in Hepatocellular Carcinoma.

Ruiz de Galarreta, Marina; Bresnahan, Erin; Molina-Sánchez, Pedro; Lindblad, Katherine E; Maier, Barbara; Sia, Daniela; Puigvehi, Marc; Miguela, Verónica; Casanova-Acebes, María; Dhainaut, Maxime; Villacorta-Martin, Carlos; Singhi, Aatur D; Moghe, Akshata; von Felden, Johann; Tal Grinspan, Lauren; Wang, Shuang; Kamphorst, Alice O; Monga, Satdarshan P; Brown, Brian D; Villanueva, Augusto; Llovet, Josep M; Merad, Miriam; Lujambio, Amaia.

Cancer Discov ; 9(8): 1124-1141, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31186238

19.

Erratum: DNA sensing in senescence.

Ruiz de Galarreta, Marina; Lujambio, Amaia.

Nat Cell Biol ; 19(12): 1441, 2017 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-29184173

20.

DNA sensing in senescence.

Ruiz de Galarreta, Marina; Lujambio, Amaia.

Nat Cell Biol ; 19(9): 1008-1009, 2017 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-28855731

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Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma.

Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma.

Cell type-specific pharmacological kinase inhibition for cancer chemoprevention.

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma.

Therapeutic editing of hepatocyte genome in vivo.

Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis.

Fibronectin peptides as potential regulators of hepatic fibrosis through apoptosis of hepatic stellate cells.

Hepatocellular carcinoma: killing one bird with two stones.

GCN2 kinase is a key regulator of fibrogenesis and acute and chronic liver injury induced by carbon tetrachloride in mice.

Antifibrogenic and apoptotic effects of Ocoxin in cultured rat hepatic stellate cells.

WNTinib is a multi-kinase inhibitor with specificity against ß-catenin mutant hepatocellular carcinoma.

Manipulating and tracking single hepatocyte behavior during mouse liver regeneration by performing hydrodynamic tail vein injection.

Tumor-Intrinsic Mechanisms Regulating Immune Exclusion in Liver Cancers.

Mouse Models of Oncoimmunology in Hepatocellular Carcinoma.

Cold-Inducible RNA Binding Protein as a Vaccination Platform to Enhance Immunotherapeutic Responses Against Hepatocellular Carcinoma.

Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology.

Genetic Modification of CD8⁺ T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies.

ß-Catenin Activation Promotes Immune Escape and Resistance to Anti-PD-1 Therapy in Hepatocellular Carcinoma.

Erratum: DNA sensing in senescence.

DNA sensing in senescence.