Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

The histone variant H2A.Z promotes splicing of weak introns.

Nissen, Kelly E; Homer, Christina M; Ryan, Colm J; Shales, Michael; Krogan, Nevan J; Patrick, Kristin L; Guthrie, Christine.

Genes Dev ; 31(7): 688-701, 2017 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-28446597

2.

Paralog dispensability shapes homozygous deletion patterns in tumor genomes.

De Kegel, Barbara; Ryan, Colm J.

Mol Syst Biol ; 19(12): e11987, 2023 Dec 06.

Artigo em Inglês | MEDLINE | ID: mdl-37963083

3.

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.

Parkhitko, Andrey A; Singh, Arashdeep; Hsieh, Sharon; Hu, Yanhui; Binari, Richard; Lord, Christopher J; Hannenhalli, Sridhar; Ryan, Colm J; Perrimon, Norbert.

PLoS Genet ; 17(2): e1009354, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33591981

4.

Exploiting Cancer Synthetic Lethality in Cancer-Lessons Learnt from PARP Inhibitors.

Pettitt, Stephen J; Ryan, Colm J; Lord, Christopher J.

Cancer Treat Res ; 186: 13-23, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37978128

5.

Paralog buffering contributes to the variable essentiality of genes in cancer cell lines.

De Kegel, Barbara; Ryan, Colm J.

PLoS Genet ; 15(10): e1008466, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31652272

6.

Accurate prediction of kinase-substrate networks using knowledge graphs.

Novácek, Vít; McGauran, Gavin; Matallanas, David; Vallejo Blanco, Adrián; Conca, Piero; Muñoz, Emir; Costabello, Luca; Kanakaraj, Kamalesh; Nawaz, Zeeshan; Walsh, Brian; Mohamed, Sameh K; Vandenbussche, Pierre-Yves; Ryan, Colm J; Kolch, Walter; Fey, Dirk.

PLoS Comput Biol ; 16(12): e1007578, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33270624

7.

Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan, Colm J; Roguev, Assen; Patrick, Kristin; Xu, Jiewei; Jahari, Harlizawati; Tong, Zongtian; Beltrao, Pedro; Shales, Michael; Qu, Hong; Collins, Sean R; Kliegman, Joseph I; Jiang, Lingli; Kuo, Dwight; Tosti, Elena; Kim, Hyun-Soo; Edelmann, Winfried; Keogh, Michael-Christopher; Greene, Derek; Tang, Chao; Cunningham, Pádraig; Shokat, Kevan M; Cagney, Gerard; Svensson, J Peter; Guthrie, Christine; Espenshade, Peter J; Ideker, Trey; Krogan, Nevan J.

Mol Cell ; 46(5): 691-704, 2012 Jun 08.

Artigo em Inglês | MEDLINE | ID: mdl-22681890

8.

MED12-related XLID disorders are dose-dependent of immediate early genes (IEGs) expression.

Donnio, Lise-Marie; Bidon, Baptiste; Hashimoto, Satoru; May, Melanie; Epanchintsev, Alexey; Ryan, Colm; Allen, William; Hackett, Anna; Gecz, Jozef; Skinner, Cindy; Stevenson, Roger E; de Brouwer, Arjan P M; Coutton, Charles; Francannet, Christine; Jouk, Pierre-Simon; Schwartz, Charles E; Egly, Jean-Marc.

Hum Mol Genet ; 26(11): 2062-2075, 2017 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-28369444

9.

High-resolution network biology: connecting sequence with function.

Ryan, Colm J; Cimermancic, Peter; Szpiech, Zachary A; Sali, Andrej; Hernandez, Ryan D; Krogan, Nevan J.

Nat Rev Genet ; 14(12): 865-79, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24197012

10.

First quantum computers need smart software.

Zeng, Will; Johnson, Blake; Smith, Robert; Rubin, Nick; Reagor, Matt; Ryan, Colm; Rigetti, Chad.

Nature ; 549(7671): 149-151, 2017 09 13.

Artigo em Inglês | MEDLINE | ID: mdl-28905929

11.

Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast.

Patrick, Kristin L; Ryan, Colm J; Xu, Jiewei; Lipp, Jesse J; Nissen, Kelly E; Roguev, Assen; Shales, Michael; Krogan, Nevan J; Guthrie, Christine.

PLoS Genet ; 11(3): e1005074, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-25825871

12.

Ultrahigh Q whispering gallery mode electro-optic resonators on a silicon photonic chip.

Soltani, Mohammad; Ilchenko, Vladimir; Matsko, Andrey; Savchenkov, Anatoliy; Schlafer, John; Ryan, Colm; Maleki, Lute.

Opt Lett ; 41(18): 4375-8, 2016 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-27628401

13.

Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression.

Fitzpatrick, Darren J; Ryan, Colm J; Shah, Naisha; Greene, Derek; Molony, Cliona; Shields, Denis C.

BMC Genomics ; 16: 109, 2015 Feb 21.

Artigo em Inglês | MEDLINE | ID: mdl-25765234

14.

The yeast SR-like protein Npl3 links chromatin modification to mRNA processing.

Moehle, Erica A; Ryan, Colm J; Krogan, Nevan J; Kress, Tracy L; Guthrie, Christine.

PLoS Genet ; 8(11): e1003101, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-23209445

15.

Genetic interactions under the microscope.

Ryan, Colm J.

Cell Syst ; 14(5): 341-342, 2023 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-37201505

16.

Antibody reliability influences observed mRNA-protein correlations in tumour samples.

Upadhya, Swathi Ramachandra; Ryan, Colm J.

Life Sci Alliance ; 6(8)2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37169592

17.

Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity.

Tudose, Cosmin; Bond, Jonathan; Ryan, Colm J.

NAR Cancer ; 5(4): zcad056, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-38035131

18.

Targeting synthetic lethal paralogs in cancer.

Ryan, Colm J; Mehta, Ishan; Kebabci, Narod; Adams, David J.

Trends Cancer ; 9(5): 397-409, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36890003

19.

Complex synthetic lethality in cancer.

Ryan, Colm J; Devakumar, Lovely Paul Solomon; Pettitt, Stephen J; Lord, Christopher J.

Nat Genet ; 55(12): 2039-2048, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-38036785

20.

Practical experimental certification of computational quantum gates using a twirling procedure.

Moussa, Osama; da Silva, Marcus P; Ryan, Colm A; Laflamme, Raymond.

Phys Rev Lett ; 109(7): 070504, 2012 Aug 17.

Artigo em Inglês | MEDLINE | ID: mdl-23006350

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