Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Kidney macrophages tap the stream.

Saavedra, Pedro H V; Perry, Justin S A.

Immunity ; 57(1): 3-5, 2024 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-38198853

2.

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

Vande Walle, Lieselotte; Stowe, Irma B; Sácha, Pavel; Lee, Bettina L; Demon, Dieter; Fossoul, Amelie; Van Hauwermeiren, Filip; Saavedra, Pedro H V; Simon, Petr; Subrt, Vladimír; Kostka, Libor; Stivala, Craig E; Pham, Victoria C; Staben, Steven T; Yamazoe, Sayumi; Konvalinka, Jan; Kayagaki, Nobuhiko; Lamkanfi, Mohamed.

PLoS Biol ; 17(9): e3000354, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31525186

3.

Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

Walle, Lieselotte Vande; Stowe, Irma B; Sácha, Pavel; Lee, Bettina L; Demon, Dieter; Fossoul, Amelie; Van Hauwermeiren, Filip; Saavedra, Pedro H V; Simon, Petr; Subr, Vladimír; Kostka, Libor; Stivala, Craig E; Pham, Victoria C; Staben, Steven T; Yamazoe, Sayumi; Konvalinka, Jan; Kayagaki, Nobuhiko; Lamkanfi, Mohamed.

PLoS Biol ; 17(10): e3000529, 2019 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-31618263

4.

Cryptococcus neoformans Secretes Small Molecules That Inhibit IL-1ß Inflammasome-Dependent Secretion.

Bürgel, Pedro Henrique; Marina, Clara Luna; Saavedra, Pedro H V; Albuquerque, Patrícia; de Oliveira, Stephan Alberto Machado; Veloso Janior, Paulo Henrique de Holanda; de Castro, Raffael Araújo; Heyman, Heino M; Coelho, Carolina; Cordero, Radames J B; Casadevall, Arturo; Nosanchuk, Joshua D; Nakayasu, Ernesto S; May, Robin C; Tavares, Aldo Henrique; Bocca, Anamelia Lorenzetti.

Mediators Inflamm ; 2020: 3412763, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-33380899

5.

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.

Van Gorp, Hanne; Saavedra, Pedro H V; de Vasconcelos, Nathalia M; Van Opdenbosch, Nina; Vande Walle, Lieselotte; Matusiak, Magdalena; Prencipe, Giusi; Insalaco, Antonella; Van Hauwermeiren, Filip; Demon, Dieter; Bogaert, Delfien J; Dullaers, Melissa; De Baere, Elfride; Hochepied, Tino; Dehoorne, Joke; Vermaelen, Karim Y; Haerynck, Filomeen; De Benedetti, Fabrizio; Lamkanfi, Mohamed.

Proc Natl Acad Sci U S A ; 113(50): 14384-14389, 2016 12 13.

Artigo em Inglês | MEDLINE | ID: mdl-27911804

6.

Immunology: Gut sensor halts viral attack.

Saavedra, Pedro H V; Lamkanfi, Mohamed.

Nature ; 546(7660): 606-608, 2017 06 29.

Artigo em Inglês | MEDLINE | ID: mdl-28636602

7.

WNK1 enforces macrophage lineage fidelity.

Trzeciak, Alissa J; Rojas, Waleska Saitz; Liu, Zong-Lin; Krebs, Adam S; Wang, Zhaoquan; Saavedra, Pedro H V; Miranda, Isabella C; Lipshutz, Allie; Xie, Jian; Huang, Chou-Long; Overholtzer, Michael; Glickman, Michael S; Parkhurst, Christopher N; Vierbuchen, Thomas; Lucas, Christopher D; Perry, Justin S A.

bioRxiv ; 2023 Apr 28.

Artigo em Inglês | MEDLINE | ID: mdl-37383948

8.

Early life high fructose exposure disrupts microglia function and impedes neurodevelopment.

Wang, Zhaoquan; Lipshutz, Allie; Liu, Zong-Lin; Trzeciak, Alissa J; Miranda, Isabella C; Martínez de la Torre, Celia; Schild, Tanya; Lazarov, Tomi; Rojas, Waleska Saitz; Saavedra, Pedro H V; Romero-Pichardo, Jesús E; Baako, Ann; Geissmann, Frederic; Faraco, Giuseppe; Gan, Li; Etchegaray, Jon Iker; Lucas, Christopher D; Parkhurst, Christopher N; Zeng, Melody Y; Keshari, Kayvan R; Perry, Justin S A.

bioRxiv ; 2023 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-37645894

9.

Immunometabolism of Tissue-Resident Macrophages - An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies.

Zago, Giulia; Saavedra, Pedro H V; Keshari, Kayvan R; Perry, Justin S A.

Front Immunol ; 12: 665782, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34025667

10.

Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice.

Dufies, Océane; Doye, Anne; Courjon, Johan; Torre, Cédric; Michel, Gregory; Loubatier, Celine; Jacquel, Arnaud; Chaintreuil, Paul; Majoor, Alissa; Guinamard, Rodolphe R; Gallerand, Alexandre; Saavedra, Pedro H V; Verhoeyen, Els; Rey, Amaury; Marchetti, Sandrine; Ruimy, Raymond; Czerucka, Dorota; Lamkanfi, Mohamed; Py, Bénédicte F; Munro, Patrick; Visvikis, Orane; Boyer, Laurent.

Nat Microbiol ; 6(3): 401-412, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33432150

11.

IL1ß Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D.

Kiss, Máté; Vande Walle, Lieselotte; Saavedra, Pedro H V; Lebegge, Els; Van Damme, Helena; Murgaski, Aleksandar; Qian, Junbin; Ehling, Manuel; Pretto, Samantha; Bolli, Evangelia; Keirsse, Jiri; Bardet, Pauline M R; Arnouk, Sana M; Elkrim, Yvon; Schmoetten, Maryse; Brughmans, Jan; Debraekeleer, Ayla; Fossoul, Amelie; Boon, Louis; Raes, Geert; van Loo, Geert; Lambrechts, Diether; Mazzone, Massimiliano; Beschin, Alain; Wullaert, Andy; Lamkanfi, Mohamed; Van Ginderachter, Jo A; Laoui, Damya.

Cancer Immunol Res ; 9(3): 309-323, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33361087

12.

Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections.

Amaral, Andre Correa; Saavedra, Pedro H V; Oliveira Souza, Ana Camila; de Melo, Maryanne Trafani; Tedesco, Antonio Claudio; Morais, Paulo Cesar; Soares Felipe, Maria Sueli; Bocca, Anamelia Lorenzetti.

Colloids Surf B Biointerfaces ; 174: 409-415, 2019 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-30481701

13.

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.

Saavedra, Pedro H V; Huang, Linyan; Ghazavi, Farzaneh; Kourula, Stephanie; Vanden Berghe, Tom; Takahashi, Nozomi; Vandenabeele, Peter; Lamkanfi, Mohamed.

Nat Commun ; 9(1): 4846, 2018 11 19.

Artigo em Inglês | MEDLINE | ID: mdl-30451870

14.

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever.

Kanneganti, Apurva; Malireddi, R K Subbarao; Saavedra, Pedro H V; Vande Walle, Lieselotte; Van Gorp, Hanne; Kambara, Hiroto; Tillman, Heather; Vogel, Peter; Luo, Hongbo R; Xavier, Ramnik J; Chi, Hongbo; Lamkanfi, Mohamed.

J Exp Med ; 215(6): 1519-1529, 2018 06 04.

Artigo em Inglês | MEDLINE | ID: mdl-29793924

15.

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.

Van Opdenbosch, Nina; Van Gorp, Hanne; Verdonckt, Maarten; Saavedra, Pedro H V; de Vasconcelos, Nathalia M; Gonçalves, Amanda; Vande Walle, Lieselotte; Demon, Dieter; Matusiak, Magdalena; Van Hauwermeiren, Filip; D'Hont, Jinke; Hochepied, Tino; Krautwald, Stefan; Kanneganti, Thirumala-Devi; Lamkanfi, Mohamed.

Cell Rep ; 21(12): 3427-3444, 2017 Dec 19.

Artigo em Inglês | MEDLINE | ID: mdl-29262324

16.

Protective and detrimental roles of inflammasomes in disease.

Saavedra, Pedro H V; Demon, Dieter; Van Gorp, Hanne; Lamkanfi, Mohamed.

Semin Immunopathol ; 37(4): 313-22, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-25895577

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