Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity.

Hickey, Bradley W; Lumsden, Joanne M; Reyes, Sharina; Sedegah, Martha; Hollingdale, Michael R; Freilich, Daniel A; Luke, Thomas C; Charoenvit, Yupin; Goh, Lucy M; Berzins, Mara P; Bebris, Lolita; Sacci, John B; De La Vega, Patricia; Wang, Ruobing; Ganeshan, Harini; Abot, Esteban N; Carucci, Daniel J; Doolan, Denise L; Brice, Gary T; Kumar, Anita; Aguiar, Joao; Nutman, Thomas B; Leitman, Susan F; Hoffman, Stephen L; Epstein, Judith E; Richie, Thomas L.

Malar J ; 15(1): 377, 2016 Jul 22.

Artigo em Inglês | MEDLINE | ID: mdl-27448805

2.

CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes.

Chakravarty, Sumana; Cockburn, Ian A; Kuk, Salih; Overstreet, Michael G; Sacci, John B; Zavala, Fidel.

Nat Med ; 13(9): 1035-41, 2007 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-17704784

3.

Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites.

Mikolajczak, Sebastian A; Sacci, John B; De La Vega, Patricia; Camargo, Nelly; VanBuskirk, Kelly; Krzych, Urszula; Cao, Jun; Jacobs-Lorena, Marcelo; Cowman, Alan F; Kappe, Stefan H I.

Cell Microbiol ; 13(8): 1250-60, 2011 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-21569184

4.

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.

VanBuskirk, Kelley M; O'Neill, Matthew T; De La Vega, Patricia; Maier, Alexander G; Krzych, Urszula; Williams, Jack; Dowler, Megan G; Sacci, John B; Kangwanrangsan, Niwat; Tsuboi, Takafumi; Kneteman, Norman M; Heppner, Donald G; Murdock, Brant A; Mikolajczak, Sebastian A; Aly, Ahmed S I; Cowman, Alan F; Kappe, Stefan H I.

Proc Natl Acad Sci U S A ; 106(31): 13004-9, 2009 Aug 04.

Artigo em Inglês | MEDLINE | ID: mdl-19625622

5.

Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase.

Nicoll, William S; Sacci, John B; Rodolfo, Carlo; Di Giacomo, Giuseppina; Piacentini, Mauro; Holland, Zoe Jm; Doerig, Christian; Hollingdale, Michael R; Lanar, David E.

Malar J ; 10: 14, 2011 Jan 21.

Artigo em Inglês | MEDLINE | ID: mdl-21255444

6.

Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages.

Mackellar, Drew C; O'Neill, Matthew T; Aly, Ahmed S I; Sacci, John B; Cowman, Alan F; Kappe, Stefan H I.

Eukaryot Cell ; 9(5): 784-94, 2010 May.

Artigo em Inglês | MEDLINE | ID: mdl-20228203

7.

Novel malaria antigen Plasmodium yoelii E140 induces antibody-mediated sterile protection in mice against malaria challenge.

Smith, Emily C; Limbach, Keith J; Rangel, Nonenipha; Oda, Kyosuke; Bolton, Jessica S; Du, Mengyan; Gowda, Kalpana; Wang, Jianyang; Moch, J Kathleen; Sonawane, Sharvari; Velasco, Rachel; Belmonte, Arnel; Danner, Rebecca; Lumsden, Joanne M; Patterson, Noelle B; Sedegah, Martha; Hollingdale, Michael R; Richie, Thomas L; Sacci, John B; Villasante, Eileen D; Aguiar, Joao C.

PLoS One ; 15(5): e0232234, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-32407410

8.

Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals.

Nguyen, Thanh V; Sacci, John B; de la Vega, Patricia; John, Chandy C; James, Anthony A; Kang, Angray S.

Malar J ; 8: 235, 2009 Oct 23.

Artigo em Inglês | MEDLINE | ID: mdl-19852802

9.

Cellular immune response to DNA and vaccinia prime-boost immunization kills Plasmodium yoelii-infected hepatocytes in vitro.

Sacci, John B; Hollingdale, Michael R; Sedegah, Martha.

Pathog Dis ; 75(4)2017 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-28475711

10.

Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers.

Sacci, John B; Alam, Uzma; Douglas, Donna; Lewis, Jamie; Tyrrell, D Lorne J; Azad, Abdu F; Kneteman, Norman M.

Int J Parasitol ; 36(3): 353-60, 2006 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-16442544

11.

Overexpression of Plasmodium berghei ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites.

Voss, Christiane; Ehrenman, Karen; Mlambo, Godfree; Mishra, Satish; Kumar, Kota Arun; Sacci, John B; Sinnis, Photini; Coppens, Isabelle.

mBio ; 7(3)2016 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-27353755

12.

Transcriptional analysis of in vivo Plasmodium yoelii liver stage gene expression.

Sacci, John B; Ribeiro, Jose M C; Huang, Fengying; Alam, Uzma; Russell, Joshua A; Blair, Peter L; Witney, Adam; Carucci, Daniel J; Azad, Abdu F; Aguiar, Joao C.

Mol Biochem Parasitol ; 142(2): 177-83, 2005 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-15876462

13.

Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development.

Aguiar, Joao C; Bolton, Jessica; Wanga, Joyce; Sacci, John B; Iriko, Hideyuki; Mazeika, Julie K; Han, Eun-Taek; Limbach, Keith; Patterson, Noelle B; Sedegah, Martha; Cruz, Ann-Marie; Tsuboi, Takafumi; Hoffman, Stephen L; Carucci, Daniel; Hollingdale, Michael R; Villasante, Eileen D; Richie, Thomas L.

PLoS One ; 10(8): e0136109, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-26292257

14.

Gene expression analysis during liver stage development of Plasmodium.

Sacci, John B; Azad, Abdu F.

Int J Parasitol ; 32(13): 1551-7, 2002 Dec 04.

Artigo em Inglês | MEDLINE | ID: mdl-12435439

15.

Subcellular localization of rickettsial invasion protein, InvA.

Gaywee, Jariyanart; Sacci, John B; Radulovic, Suzana; Beier, Magda S; Azad, Abdu F.

Am J Trop Med Hyg ; 68(1): 92-6, 2003 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-12556155

16.

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA.

Richie, Thomas L; Charoenvit, Yupin; Wang, Ruobing; Epstein, Judith E; Hedstrom, Richard C; Kumar, Sanjai; Luke, Thomas C; Freilich, Daniel A; Aguiar, Joao C; Sacci, John B; Sedegah, Martha; Nosek, Ronald A; De La Vega, Patricia; Berzins, Mara P; Majam, Victoria F; Abot, Esteban N; Ganeshan, Harini; Richie, Nancy O; Banania, Jo Glenna; Baraceros, Maria Fe B; Geter, Tanya G; Mere, Robin; Bebris, Lolita; Limbach, Keith; Hickey, Bradley W; Lanar, David E; Ng, Jennifer; Shi, Meng; Hobart, Peter M; Norman, Jon A; Soisson, Lorraine A; Hollingdale, Michael R; Rogers, William O; Doolan, Denise L; Hoffman, Stephen L.

Hum Vaccin Immunother ; 8(11): 1564-84, 2012 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-23151451

17.

Laser capture microdissection and molecular analysis of Plasmodium yoelii liver-stage parasites.

Sacci, John B; Aguiar, Joao C; Lau, Audrey O; Hoffman, Stephen L.

Mol Biochem Parasitol ; 119(2): 285-9, 2002 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-11814581

18.

Hepatic portal branch inoculation.

Sacci, John B.

Methods Mol Med ; 72: 499-501, 2002.

Artigo em Inglês | MEDLINE | ID: mdl-12125146

19.

Hepatocyte perfusion, isolation, and culture.

Sacci, John B.

Methods Mol Med ; 72: 503-5, 2002.

Artigo em Inglês | MEDLINE | ID: mdl-12125147

20.

Inhibition of liver-stage development assay.

Sacci, John B.

Methods Mol Med ; 72: 517-20, 2002.

Artigo em Inglês | MEDLINE | ID: mdl-12125149

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Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity.

CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes.

Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites.

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.

Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase.

Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages.

Novel malaria antigen Plasmodium yoelii E140 induces antibody-mediated sterile protection in mice against malaria challenge.

Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals.

Cellular immune response to DNA and vaccinia prime-boost immunization kills Plasmodium yoelii-infected hepatocytes in vitro.

Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers.

Overexpression of Plasmodium berghei ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites.

Transcriptional analysis of in vivo Plasmodium yoelii liver stage gene expression.

Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development.

Gene expression analysis during liver stage development of Plasmodium.

Subcellular localization of rickettsial invasion protein, InvA.

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA.

Laser capture microdissection and molecular analysis of Plasmodium yoelii liver-stage parasites.

Hepatic portal branch inoculation.

Hepatocyte perfusion, isolation, and culture.

Inhibition of liver-stage development assay.