Detalhe da pesquisa
1.
Highly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response.
Proc Natl Acad Sci U S A
; 120(52): e2306090120, 2023 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38117854
2.
Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain.
Pharmacol Rev
; 73(1): 59-88, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33203717
3.
Identification of the gene that codes for the σ2 receptor.
Proc Natl Acad Sci U S A
; 114(27): 7160-7165, 2017 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28559337
4.
Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease.
J Neurochem
; 140(4): 561-575, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27926996
5.
Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification.
Org Biomol Chem
; 12(39): 7659-72, 2014 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25135846
6.
MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.
Neuroscience
; 515: 96-107, 2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36764601
7.
MNK1 and MNK2 expression in the human dorsal root and trigeminal ganglion.
bioRxiv
; 2023 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711529
8.
Highly specific σ2R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress response.
bioRxiv
; 2023 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37090527
9.
APPLICATIONS OF MULTICOMPONENT ASSEMBLY PROCESSES TO THE FACILE SYNTHESES OF DIVERSELY FUNCTIONALIZED NITROGEN HETEROCYCLES.
Heterocycles
; 84(2): 1089-1112, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22451742
10.
Targeting σ2R/TMEM97 with novel aminotetralins.
Eur J Med Chem
; 243: 114696, 2022 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36088757
11.
Neuroprotective Effects of σ2R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington's Disease.
ACS Chem Neurosci
; 13(19): 2852-2862, 2022 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36108101
12.
σ2R/TMEM97 in retinal ganglion cell degeneration.
Sci Rep
; 12(1): 20753, 2022 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36456686
13.
Facile Syntheses of Substituted, Conformationally-Constrained Benzoxazocines and Benzazocines via Sequential Multicomponent Assembly and Cyclization.
Tetrahedron Lett
; 52(51): 6855-6858, 2011 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22711939
14.
The Sigma-2 receptor / transmembrane protein 97 (σ2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice.
Neuropharmacology
; 184: 108409, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33221481
15.
[2 + 2] Photochemical cycloaddition/ring opening of 6-alkenyl-2,3-dihydro-4-pyridones.
J Org Chem
; 75(19): 6728-31, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20806926
16.
Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury.
ACS Chem Neurosci
; 10(3): 1595-1602, 2019 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30421909
17.
Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties.
Eur J Med Chem
; 151: 557-567, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29656199
18.
Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors.
Neuropsychopharmacology
; 43(9): 1867-1875, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29728649
19.
High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model.
ACS Chem Neurosci
; 9(5): 1014-1026, 2018 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29426225
20.
Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity.
ACS Med Chem Lett
; 8(4): 455-460, 2017 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28435536