Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Cryo-EM in molecular and cellular biology.

Saibil, Helen R.

Mol Cell ; 82(2): 274-284, 2022 01 20.

Artigo em Inglês | MEDLINE | ID: mdl-35063096

2.

Structural basis of ubiquitin-independent PP1 complex disassembly by p97.

van den Boom, Johannes; Marini, Guendalina; Meyer, Hemmo; Saibil, Helen R.

EMBO J ; 42(14): e113110, 2023 07 17.

Artigo em Inglês | MEDLINE | ID: mdl-37264685

3.

ATP-triggered conformational changes delineate substrate-binding and -folding mechanics of the GroEL chaperonin.

Clare, Daniel K; Vasishtan, Daven; Stagg, Scott; Quispe, Joel; Farr, George W; Topf, Maya; Horwich, Arthur L; Saibil, Helen R.

Cell ; 149(1): 113-23, 2012 Mar 30.

Artigo em Inglês | MEDLINE | ID: mdl-22445172

4.

Cooperative amyloid fibre binding and disassembly by the Hsp70 disaggregase.

Beton, Joseph George; Monistrol, Jim; Wentink, Anne; Johnston, Erin C; Roberts, Anthony John; Bukau, Bernd Gerhard; Hoogenboom, Bart W; Saibil, Helen R.

EMBO J ; 41(16): e110410, 2022 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-35698800

5.

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.

Peskett, Thomas R; Rau, Frédérique; O'Driscoll, Jonathan; Patani, Rickie; Lowe, Alan R; Saibil, Helen R.

Mol Cell ; 70(4): 588-601.e6, 2018 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-29754822

6.

Structural basis of substrate progression through the bacterial chaperonin cycle.

Gardner, Scott; Darrow, Michele C; Lukoyanova, Natalya; Thalassinos, Konstantinos; Saibil, Helen R.

Proc Natl Acad Sci U S A ; 120(50): e2308933120, 2023 Dec 12.

Artigo em Inglês | MEDLINE | ID: mdl-38064510

7.

A structural basis for prion strain diversity.

Manka, Szymon W; Wenborn, Adam; Betts, Jemma; Joiner, Susan; Saibil, Helen R; Collinge, John; Wadsworth, Jonathan D F.

Nat Chem Biol ; 19(5): 607-613, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36646960

8.

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.

Gao, Xuechao; Carroni, Marta; Nussbaum-Krammer, Carmen; Mogk, Axel; Nillegoda, Nadinath B; Szlachcic, Anna; Guilbride, D Lys; Saibil, Helen R; Mayer, Matthias P; Bukau, Bernd.

Mol Cell ; 59(5): 781-93, 2015 Sep 03.

Artigo em Inglês | MEDLINE | ID: mdl-26300264

9.

The PDB and protein homeostasis: From chaperones to degradation and disaggregase machines.

Saibil, Helen R.

J Biol Chem ; 296: 100744, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33957121

10.

Spiers Memorial Lecture: Challenges in cryo electron microscopy.

Saibil, Helen R.

Faraday Discuss ; 240(0): 10-17, 2022 11 08.

Artigo em Inglês | MEDLINE | ID: mdl-36218050

11.

Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress.

Hale, Victoria L; Watermeyer, Jean M; Hackett, Fiona; Vizcay-Barrena, Gema; van Ooij, Christiaan; Thomas, James A; Spink, Matthew C; Harkiolaki, Maria; Duke, Elizabeth; Fleck, Roland A; Blackman, Michael J; Saibil, Helen R.

Proc Natl Acad Sci U S A ; 114(13): 3439-3444, 2017 03 28.

Artigo em Inglês | MEDLINE | ID: mdl-28292906

12.

REMBI: Recommended Metadata for Biological Images-enabling reuse of microscopy data in biology.

Sarkans, Ugis; Chiu, Wah; Collinson, Lucy; Darrow, Michele C; Ellenberg, Jan; Grunwald, David; Hériché, Jean-Karim; Iudin, Andrii; Martins, Gabriel G; Meehan, Terry; Narayan, Kedar; Patwardhan, Ardan; Russell, Matthew Robert Geoffrey; Saibil, Helen R; Strambio-De-Castillia, Caterina; Swedlow, Jason R; Tischer, Christian; Uhlmann, Virginie; Verkade, Paul; Barlow, Mary; Bayraktar, Omer; Birney, Ewan; Catavitello, Cesare; Cawthorne, Christopher; Wagner-Conrad, Stephan; Duke, Elizabeth; Paul-Gilloteaux, Perrine; Gustin, Emmanuel; Harkiolaki, Maria; Kankaanpää, Pasi; Lemberger, Thomas; McEntyre, Jo; Moore, Josh; Nicholls, Andrew W; Onami, Shuichi; Parkinson, Helen; Parsons, Maddy; Romanchikova, Marina; Sofroniew, Nicholas; Swoger, Jim; Utz, Nadine; Voortman, Lenard M; Wong, Frances; Zhang, Peijun; Kleywegt, Gerard J; Brazma, Alvis.

Nat Methods ; 18(12): 1418-1422, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34021280

13.

The membrane attack complex, perforin and cholesterol-dependent cytolysin superfamily of pore-forming proteins.

Lukoyanova, Natalya; Hoogenboom, Bart W; Saibil, Helen R.

J Cell Sci ; 129(11): 2125-33, 2016 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-27179071

14.

A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes.

Watermeyer, Jean M; Hale, Victoria L; Hackett, Fiona; Clare, Daniel K; Cutts, Erin E; Vakonakis, Ioannis; Fleck, Roland A; Blackman, Michael J; Saibil, Helen R.

Blood ; 127(3): 343-51, 2016 Jan 21.

Artigo em Inglês | MEDLINE | ID: mdl-26637786

15.

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova, Natalya; Kondos, Stephanie C; Farabella, Irene; Law, Ruby H P; Reboul, Cyril F; Caradoc-Davies, Tom T; Spicer, Bradley A; Kleifeld, Oded; Traore, Daouda A K; Ekkel, Susan M; Voskoboinik, Ilia; Trapani, Joseph A; Hatfaludi, Tamas; Oliver, Katherine; Hotze, Eileen M; Tweten, Rodney K; Whisstock, James C; Topf, Maya; Saibil, Helen R; Dunstone, Michelle A.

PLoS Biol ; 13(2): e1002049, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25654333

16.

Blob-ology and biology of cryo-EM: an interview with Helen Saibil.

Saibil, Helen R.

BMC Biol ; 15(1): 77, 2017 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-28859647

17.

Map/model validation and machine learning in EM: general discussion.

Bakker, Saskia E; Bergeron, Julien; Bharadwaj, Alok; Bhella, David; Bullough, Per; Chau, Pak-Lee; Frank, René A W; Jakobi, Arjen J; Joseph, Agnel Praveen; Kühlbrandt, Werner; Lahiri, Indrajit; Menday, Rebbekah; Muench, Stephen P; Nakasone, Mark; Nerukh, Dmitry; Paris, Giulia; Russo, Christopher J; Saibil, Helen R; Scheres, Sjors H W; Sehrawat, Vidhi; Shah, Archna R; Thorn, Andrea; Vilas, José Luis; Zanetti, Giulia.

Faraday Discuss ; 240(0): 229-242, 2022 11 08.

Artigo em Inglês | MEDLINE | ID: mdl-36254744

18.

Sample preparation in single particle cryo-EM: general discussion.

Al-Otaibi, Natalie; Aminian J, Atieh; Anane, Rex Frimpong; Baatsen, Pieter; Bakker, Saskia E; Bergeron, Julien; Bharadwaj, Alok; Bhella, David; Braun, Thomas; Brescia, Rosaria; Bullough, Per; Clare, Daniel K; Daum, Bertram; Esser, Tim K; Farinas Lucas, Irene Del Mar; Frank, René A W; Gold, Vicki A M; Harrison, Peter J; Hirst, Isobel Jackson; Klebl, David P; Kühlbrandt, Werner; Morton, Christopher; Muench, Stephen P; Nakasone, Mark; Russo, Christopher J; Saibil, Helen R; Scheres, Sjors H W; Sehrawat, Vidhi; Shah, Archna R; Smith, Corinne; Thompson, Rebecca F; Thorn, Andrea; Zanetti, Giulia.

Faraday Discuss ; 240(0): 81-100, 2022 11 08.

Artigo em Inglês | MEDLINE | ID: mdl-36278863

19.

Cryo electron microscopy to determine the structure of macromolecular complexes.

Carroni, Marta; Saibil, Helen R.

Methods ; 95: 78-85, 2016 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-26638773

20.

Motor mechanism for protein threading through Hsp104.

Wendler, Petra; Shorter, James; Snead, David; Plisson, Celia; Clare, Daniel K; Lindquist, Susan; Saibil, Helen R.

Mol Cell ; 34(1): 81-92, 2009 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-19362537

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Cryo-EM in molecular and cellular biology.

Structural basis of ubiquitin-independent PP1 complex disassembly by p97.

ATP-triggered conformational changes delineate substrate-binding and -folding mechanics of the GroEL chaperonin.

Cooperative amyloid fibre binding and disassembly by the Hsp70 disaggregase.

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.

Structural basis of substrate progression through the bacterial chaperonin cycle.

A structural basis for prion strain diversity.

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.

The PDB and protein homeostasis: From chaperones to degradation and disaggregase machines.

Spiers Memorial Lecture: Challenges in cryo electron microscopy.

Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress.

REMBI: Recommended Metadata for Biological Images-enabling reuse of microscopy data in biology.

The membrane attack complex, perforin and cholesterol-dependent cytolysin superfamily of pore-forming proteins.

A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes.

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Blob-ology and biology of cryo-EM: an interview with Helen Saibil.

Map/model validation and machine learning in EM: general discussion.

Sample preparation in single particle cryo-EM: general discussion.

Cryo electron microscopy to determine the structure of macromolecular complexes.

Motor mechanism for protein threading through Hsp104.