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1.
Neuropsychobiology ; 67(2): 122-6, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23406654

RESUMO

BACKGROUND: Quantitative electroencephalogram (qEEG) changes in chronic hepatitis C patients treated with interferon-α (IFN-α) have previously been reported. However, whether IFN-α-induced depression is related to changes in qEEG during IFN-α treatment remains unclear. METHOD: Fifty chronic hepatitis C patients were enrolled and IFN-α was administered intramuscularly at 9 × 10(6) IU daily for the first 4 weeks and then 3 times a week for the next 20 weeks. Serial EEGs obtained before and at 4 weeks after treatment were assessed. The absolute power for each frequency band was determined using qEEG techniques. Differences in the rate of change in absolute power for each of 6 frequency bands (δ, θ1, θ2, α1, α2 and ß) were assessed between patients with and without major depression using the Mann-Whitney U test. When significant differences in the rate of change in absolute power for each frequency band were observed, differences in the rate of change were also assessed between patients with and without psychological complications using the Mann-Whitney U test. RESULTS: Major depression due to psychological complications during IFN-α treatment was reported in 10 out of 50 patients. In the θ1 band, the difference in the rate of change was demonstrated to be significant (p = 0.0036). Moreover, at the central, frontal, parietal, and temporal locations, the rates of change were also significantly different. CONCLUSION: In IFN-α-treated chronic hepatitis C patients who were diagnosed with major depression, qEEG changes were more obvious and widely distributed.


Assuntos
Ondas Encefálicas/efeitos dos fármacos , Depressão/induzido quimicamente , Depressão/fisiopatologia , Eletroencefalografia , Fatores Imunológicos/efeitos adversos , Interferon-alfa/efeitos adversos , Adulto , Idoso , Mapeamento Encefálico , Feminino , Hepatite C Crônica/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Estatísticas não Paramétricas , Adulto Jovem
2.
Psychiatry Clin Neurosci ; 62(4): 396-403, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18778436

RESUMO

AIMS: Exploratory eye movement (EEM), P300 and reaction time (RT) tests may relate to the important parts of information processing in the human brain. Therefore the aim of the present study was to compare EEM, P300 and RT test data in schizophrenic and normal control groups to investigate whether schizophrenic patients have information processing abnormalities. In addition, the potential correspondence between the three tests was examined in order to investigate the information processing dysfunctions seen in schizophrenic patients. METHODS: The EEM, P300 and RT performances were recorded in 34 schizophrenic and 36 normal control subjects. Ten parameters were measured: four from the EEM test (number of eye fixations, total eye scanning length, cognitive search score and responsive search score [RSS]); two from the P300 test (amplitude and latency); and four from the RT test (simple reaction time, index of reaction time crossover [IRT-crossover], set index and coefficient of variation). RESULTS: These parameters in the schizophrenic patients differed significantly from those in the control group. Additionally, there was a significant correlation between the RSS and the IRT-crossover in the schizophrenic patients. CONCLUSION: The present group comparisons (schizophrenia vs normal controls) are consistent with previous studies in that the abnormalities in EEM, P300 and RT tests in schizophrenic patients were able to be replicated. Moreover, based on the former psychological theory, it is reasonable to propose that the RSS is associated with the IRT-crossover. The present results may contribute to elucidation of the pathophysiological signature of schizophrenia.


Assuntos
Atenção/fisiologia , Potenciais Evocados P300/fisiologia , Movimentos Oculares/fisiologia , Orientação/fisiologia , Reconhecimento Visual de Modelos/fisiologia , Tempo de Reação/fisiologia , Esquizofrenia/fisiopatologia , Adulto , Córtex Cerebral/fisiopatologia , Percepção de Cores/fisiologia , Aprendizagem por Discriminação/fisiologia , Feminino , Humanos , Masculino , Memória de Curto Prazo/fisiologia , Testes Neuropsicológicos , Desempenho Psicomotor/fisiologia , Valores de Referência , Esquizofrenia/diagnóstico
3.
J Clin Neurophysiol ; 22(1): 49-52, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15689713

RESUMO

The authors recently observed alterations in the quantitative EEG findings in patients with chronic hepatitis C who were treated with interferon-alpha (IFN-alpha). However, the factors that influenced such EEG alterations remain unclear. The authors evaluated the correlation between QEEG alterations that occurred during IFN-alpha treatment and the age of 98 patients with chronic hepatitis C. These patients underwent blind, prospective, and serial quantitative EEG examinations. IFN-alpha was administered intramuscularly at 9 x 10 IU daily for the first 4 weeks and then three times per week for the next 20 weeks. Serial EEGs were obtained before, at 2 and 4 weeks, and at 2 to 3 days after the treatment. The absolute powers of each frequency band at different stages of the treatment were determined by QEEG. The ages of the patients were classified into five groups: 20 to 29, 30 to 39, 40 to 49, 50 to 59, and > or =60 years. The relationship between the alterations in power values and age was statistically evaluated. As the age of the patients increased, the alterations in power values for the slow waves, alpha 2, and fast waves during IFN-alpha treatment became more remarkable, and significant (repeated-measure analysis of variance; P < 0.0001). The alterations of EEG occurring during IFN-alpha treatment were marked in older patients.


Assuntos
Envelhecimento/fisiologia , Eletroencefalografia/efeitos dos fármacos , Hepatite C Crônica/fisiopatologia , Interferon-alfa/farmacologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Método Duplo-Cego , Esquema de Medicação , Avaliação de Medicamentos , Hepatite C Crônica/tratamento farmacológico , Humanos , Interferon-alfa/uso terapêutico , Pessoa de Meia-Idade , Naftalenos , Oxepinas , Estudos Prospectivos , Reprodutibilidade dos Testes , Estudos Retrospectivos , Fatores de Tempo
5.
Intern Med ; 48(12): 975-80, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19525583

RESUMO

OBJECTIVE: We have observed alterations of quantitative (q)-EEG findings occurring in interferon (IFN)-alpha treated chronic hepatitis C (CH-C) patients, and found patient's age to be one factor influencing such EEG alterations. In the present study we evaluated the correlation between q-EEG alterations during IFN-alpha treatment and the severity of hepatitis based on liver biopsies. METHODS: A total of 102 CH-C patients underwent blind, prospective and serial q-EEG examinations. The IFN-alpha was administered under the same therapeutic regimen to all patients. Serial EEGs were obtained before, at 2 and 4 weeks, and at 2-3 days after the conclusion of treatment. The absolute powers of each frequency band in different periods were determined by q-EEG. Staging (of fibrosis) and grading (of inflammatory cell infiltration) were scaled according to Desmet's classification. We evaluated the relationship between q-EEG and scales of staging or grading. RESULTS: Age distributions did not differ significantly among stages or grades. As the stage or grade increased, the alterations of EEG during IFN-alpha treatment became more pronounced, and significant (repeated-measures analysis of variances; both, p<0.0001). CONCLUSION: Alterations of the EEG occurring during IFN-alpha treatment became pronounced with more severe pathological findings for CH-C. Alterations in the EEGs during IFN-alpha treatment should be carefully monitored in CH-C patients with severe pathological findings.


Assuntos
Antivirais/uso terapêutico , Eletroencefalografia , Hepatite C Crônica/tratamento farmacológico , Hepatite C Crônica/patologia , Interferon-alfa/uso terapêutico , Fígado/patologia , Adulto , Biópsia , Hepatite C Crônica/fisiopatologia , Humanos , Cirrose Hepática/patologia , Pessoa de Meia-Idade , Estudos Prospectivos , Estudos Retrospectivos , Índice de Gravidade de Doença , Método Simples-Cego
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