Detalhe da pesquisa
1.
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
J Am Chem Soc
; 144(7): 2905-2920, 2022 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35142215
2.
An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice.
Bioorg Med Chem Lett
; 28(14): 2446-2450, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29929882
3.
Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease.
Bioorg Med Chem
; 24(12): 2603-20, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27160057
4.
Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.
Bioorg Med Chem
; 22(23): 6595-6615, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25456385
5.
Aminocarbonylation of 4-iodo-1H-imidazoles with an amino acid amide nucleophile: synthesis of constrained H-Phe-Phe-NH2 analogues.
J Org Chem
; 78(23): 12251-6, 2013 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24171628
6.
The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system.
Mol Pain
; 7: 85, 2011 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22040520
7.
P2-P1' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis.
Bioorg Med Chem
; 19(16): 4917-27, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782454
8.
The amino-terminal heptapeptide of the algesic substance P provides analgesic effect in relieving chronic neuropathic pain.
Eur J Pharmacol
; 892: 173820, 2021 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33345847
9.
Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation.
Eur J Med Chem
; 224: 113699, 2021 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34352713
10.
Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors.
Antiviral Res
; 190: 105074, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872674
11.
Discovery of achiral inhibitors of the hepatitis C virus NS3 protease based on 2(1H)-pyrazinones.
Bioorg Med Chem
; 18(17): 6512-25, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20673728
12.
Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents.
Bioorg Med Chem
; 18(14): 5413-24, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20541424
13.
Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease.
J Biomol Struct Dyn
; 38(18): 5526-5536, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31880199
14.
Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP).
RSC Med Chem
; 11(2): 234-244, 2020 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479630
15.
A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones.
Org Biomol Chem
; 7(13): 2809-15, 2009 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19532999
16.
Small peptides mimicking substance P (1-7) and encompassing a C-terminal amide functionality.
Neuropeptides
; 42(1): 31-7, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18093649
17.
Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety.
Bioorg Med Chem
; 16(6): 2955-67, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18194867
18.
Beta-amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors.
Bioorg Med Chem
; 16(10): 5590-605, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18434166
19.
From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidomimetics.
Curr Protein Pept Sci
; 19(11): 1038-1048, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29745331
20.
Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold.
Eur J Med Chem
; 148: 453-464, 2018 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29477077