Detalhe da pesquisa
1.
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis.
Sci Transl Med
; 15(725): eadh0908, 2023 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38055803
2.
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 64(9): 6037-6058, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33939425
3.
Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.
J Med Chem
; 64(19): 14557-14586, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34581584
4.
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.
Bioorg Med Chem Lett
; 20(15): 4447-50, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20594841
5.
Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG.
Bioorg Med Chem Lett
; 20(21): 6237-41, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20843687
6.
Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.
Bioorg Med Chem Lett
; 20(5): 1524-7, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149657
7.
The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis.
J Clin Med
; 9(4)2020 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32316235
8.
Antitumorigenic Effects of Inhibiting Ephrin Receptor Kinase Signaling by GLPG1790 against Colorectal Cancer Cell Lines In Vitro and In Vivo.
J Oncol
; 2020: 9342732, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184826
9.
Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
J Med Chem
; 63(22): 13526-13545, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902984
10.
The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models.
Cancers (Basel)
; 11(3)2019 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30871240
11.
Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells.
J Hematol Oncol
; 10(1): 161, 2017 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28985758
12.
Reinvestigation of the Branimycin Stereochemistry at Position 17-C.
Org Lett
; 18(4): 780-3, 2016 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26849068
13.
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
J Med Chem
; 57(23): 10044-57, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25380412