Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.

Lagnado, Anthony; Leslie, Jack; Ruchaud-Sparagano, Marie-Helene; Victorelli, Stella; Hirsova, Petra; Ogrodnik, Mikolaj; Collins, Amy L; Vizioli, Maria Grazia; Habiballa, Leena; Saretzki, Gabriele; Evans, Shane A; Salmonowicz, Hanna; Hruby, Adam; Geh, Daniel; Pavelko, Kevin D; Dolan, David; Reeves, Helen L; Grellscheid, Sushma; Wilson, Colin H; Pandanaboyana, Sanjay; Doolittle, Madison; von Zglinicki, Thomas; Oakley, Fiona; Gallage, Suchira; Wilson, Caroline L; Birch, Jodie; Carroll, Bernadette; Chapman, James; Heikenwalder, Mathias; Neretti, Nicola; Khosla, Sundeep; Masuda, Claudio Akio; Tchkonia, Tamar; Kirkland, James L; Jurk, Diana; Mann, Derek A; Passos, João F.

EMBO J ; 40(9): e106048, 2021 05 03.

Artigo em Inglês | MEDLINE | ID: mdl-33764576

2.

The Telomerase Connection of the Brain and Its Implications for Neurodegenerative Diseases.

Saretzki, Gabriele.

Stem Cells ; 41(3): 233-241, 2023 03 17.

Artigo em Inglês | MEDLINE | ID: mdl-36330760

3.

Role of Telomeres and Telomerase in Cancer and Aging.

Saretzki, Gabriele.

Int J Mol Sci ; 24(12)2023 Jun 09.

Artigo em Inglês | MEDLINE | ID: mdl-37373080

4.

CRISPR/Cas: A New Tool in the Research of Telomeres and Telomerase as Well as a Novel Form of Cancer Therapy.

Porika, Mahendar; Tippani, Radhika; Saretzki, Gabriele Christine.

Int J Mol Sci ; 23(6)2022 Mar 10.

Artigo em Inglês | MEDLINE | ID: mdl-35328421

5.

Protective effect of argan oil on DNA damage in vivo and in vitro.

Bouchab, Habiba; Ishaq, Abbas; El Kebbaj, Riad; Nasser, Boubker; Saretzki, Gabriele.

Biomarkers ; 26(5): 425-433, 2021 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-33843382

6.

Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo, Clara; Marques, Francisco D M; Anderson, Rhys; Hewitt, Graeme; Hewitt, Rachael; Cole, John; Carroll, Bernadette M; Miwa, Satomi; Birch, Jodie; Merz, Alina; Rushton, Michael D; Charles, Michelle; Jurk, Diana; Tait, Stephen W G; Czapiewski, Rafal; Greaves, Laura; Nelson, Glyn; Bohlooly-Y, Mohammad; Rodriguez-Cuenca, Sergio; Vidal-Puig, Antonio; Mann, Derek; Saretzki, Gabriele; Quarato, Giovanni; Green, Douglas R; Adams, Peter D; von Zglinicki, Thomas; Korolchuk, Viktor I; Passos, João F.

EMBO J ; 35(7): 724-42, 2016 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-26848154

7.

Human Endometrial Carcinogenesis Is Associated with Significant Reduction in Long Non-Coding RNA, TERRA.

Adishesh, Meera; Alnafakh, Rafah; Baird, Duncan M; Jones, Rhiannon E; Simon, Shannon; Button, Lucy; Kamal, Areege M; Kirwan, John; DeCruze, S Bridget; Drury, Josephine; Saretzki, Gabriele; Hapangama, Dharani K.

Int J Mol Sci ; 21(22)2020 Nov 18.

Artigo em Inglês | MEDLINE | ID: mdl-33217925

8.

Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells.

Richardson, Gavin David; Sage, Andrew; Bennaceur, Karim; Al Zhrany, Nayef; Coelho-Lima, Jose; Dookun, Emily; Draganova, Lilia; Saretzki, Gabriele; Breault, David T; Mallat, Ziad; Spyridopoulos, Ioakim.

Arterioscler Thromb Vasc Biol ; 38(6): 1283-1296, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29599138

9.

Telomeres, Telomerase and Ageing.

Saretzki, Gabriele.

Subcell Biochem ; 90: 221-308, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30779012

10.

Telomerase Does Not Improve DNA Repair in Mitochondria upon Stress but Increases MnSOD Protein under Serum-Free Conditions.

Martens, Alexander; Schmid, Bianca; Akintola, Olasubomi; Saretzki, Gabriele.

Int J Mol Sci ; 21(1)2019 Dec 19.

Artigo em Inglês | MEDLINE | ID: mdl-31861522

11.

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.

Hallam, Dean; Collin, Joseph; Bojic, Sanja; Chichagova, Valeria; Buskin, Adriana; Xu, Yaobo; Lafage, Lucia; Otten, Elsje G; Anyfantis, George; Mellough, Carla; Przyborski, Stefan; Alharthi, Sameer; Korolchuk, Viktor; Lotery, Andrew; Saretzki, Gabriele; McKibbin, Martin; Armstrong, Lyle; Steel, David; Kavanagh, David; Lako, Majlinda.

Stem Cells ; 35(11): 2305-2320, 2017 11.

Artigo em Inglês | MEDLINE | ID: mdl-28913923

12.

The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.

Spilsbury, Alison; Miwa, Satomi; Attems, Johannes; Saretzki, Gabriele.

J Neurosci ; 35(4): 1659-74, 2015 Jan 28.

Artigo em Inglês | MEDLINE | ID: mdl-25632141

13.

Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress.

Ashor, Ammar W; Chowdhury, Shakir; Oggioni, Clio; Qadir, Othman; Brandt, Kirsten; Ishaq, Abbas; Mathers, John C; Saretzki, Gabriele; Siervo, Mario.

J Nutr ; 146(11): 2224-2232, 2016 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-27733522

14.

Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

Yung, Sun K; Tilgner, Katarzyna; Ledran, Maria H; Habibollah, Saba; Neganova, Irina; Singhapol, Chatchawan; Saretzki, Gabriele; Stojkovic, Miodrag; Armstrong, Lyle; Przyborski, Stefan; Lako, Majlinda.

Stem Cells ; 31(5): 1022-9, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23280624

15.

Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors.

Tilgner, Katarzyna; Neganova, Irina; Singhapol, Chatchawan; Saretzki, Gabriele; Al-Aama, Jumana Yousuf; Evans, Jerome; Gorbunova, Vera; Gennery, Andrew; Przyborski, Stefan; Stojkovic, Miodrag; Armstrong, Lyle; Jeggo, Penny; Lako, Majlinda.

Stem Cells ; 31(9): 2015-23, 2013 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-23818183

16.

Measuring telomerase activity using TRAP assays.

Saretzki, Gabriele.

Methods Cell Biol ; 181: 127-149, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38302235

17.

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.

Jiang, Yan; Cowley, Sally A; Siler, Ulrich; Melguizo, Dario; Tilgner, Katarzyna; Browne, Cathy; Dewilton, Angus; Przyborski, Stefan; Saretzki, Gabriele; James, William S; Seger, Reinhard A; Reichenbach, Janine; Lako, Majlinda; Armstrong, Lyle.

Stem Cells ; 30(4): 599-611, 2012 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-22311747

18.

The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult.

Tsolou, Avgi; Nelson, Glyn; Trachana, Varvara; Chondrogianni, Niki; Saretzki, Gabriele; von Zglinicki, Thomas; Gonos, Efstathios S.

IUBMB Life ; 64(5): 432-42, 2012 May.

Artigo em Inglês | MEDLINE | ID: mdl-22473755

19.

Telomerase and neurons: an unusual relationship.

Saretzki, Gabriele.

Neural Regen Res ; 17(11): 2364-2367, 2022 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-35535872

20.

Mitochondrial sirtuins in stem cells and cancer.

Jaiswal, Amit; Xudong, Zhu; Zhenyu, Ju; Saretzki, Gabriele.

FEBS J ; 289(12): 3393-3415, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-33866670

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Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.

The Telomerase Connection of the Brain and Its Implications for Neurodegenerative Diseases.

Role of Telomeres and Telomerase in Cancer and Aging.

CRISPR/Cas: A New Tool in the Research of Telomeres and Telomerase as Well as a Novel Form of Cancer Therapy.

Protective effect of argan oil on DNA damage in vivo and in vitro.

Mitochondria are required for pro-ageing features of the senescent phenotype.

Human Endometrial Carcinogenesis Is Associated with Significant Reduction in Long Non-Coding RNA, TERRA.

Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells.

Telomeres, Telomerase and Ageing.

Telomerase Does Not Improve DNA Repair in Mitochondria upon Stress but Increases MnSOD Protein under Serum-Free Conditions.

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.

The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.

Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress.

Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors.

Measuring telomerase activity using TRAP assays.

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.

The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult.

Telomerase and neurons: an unusual relationship.

Mitochondrial sirtuins in stem cells and cancer.