Detalhe da pesquisa
1.
Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.
Bioorg Med Chem Lett
; 30(12): 127174, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32334912
2.
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
Bioorg Med Chem Lett
; 30(12): 127205, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32336498
3.
Identification and biological evaluation of thiazole-based inverse agonists of RORγt.
Bioorg Med Chem Lett
; 28(9): 1446-1455, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29631962
4.
Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties.
Bioorg Med Chem Lett
; 26(15): 3746-53, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27268696
5.
αPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes.
J Immunol
; 192(7): 3228-38, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24591366
6.
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and RORγt.
Bioorg Med Chem Lett
; 24(22): 5265-7, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25305688
7.
Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice.
J Pharmacol Exp Ther
; 343(3): 556-67, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22918042
8.
Non-esterified polyunsaturated fatty acids distinctly modulate the mitochondrial and cellular ROS production in normoxia and hypoxia.
J Neurochem
; 118(1): 69-78, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21517851
9.
A Water-free 0.1% Cyclosporine A Solution for Treatment of Dry Eye Disease: Results of the Randomized Phase 2B/3 ESSENCE Study.
Cornea
; 40(10): 1290-1297, 2021 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34481407
10.
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.
Bioorg Med Chem Lett
; 20(16): 4911-7, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20638278
11.
Numb3 is an endocytosis adaptor for the inflammatory marker P-selectin.
Biochem Biophys Res Commun
; 379(4): 909-13, 2009 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19138666
12.
Regulation of IL-1 signaling by the decoy receptor IL-1R2.
J Mol Med (Berl)
; 96(10): 983-992, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30109367
13.
Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.
Mol Biol Cell
; 15(7): 3095-105, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15121882
14.
CRISPR/Cas9-mediated knockout of c-REL in HeLa cells results in profound defects of the cell cycle.
PLoS One
; 12(8): e0182373, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28767691
15.
Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.
J Mol Biol
; 347(4): 813-25, 2005 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15769472
16.
FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.
PLoS One
; 7(10): e43044, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23056173
17.
Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1.
Biochem Biophys Res Commun
; 345(3): 1264-72, 2006 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16712798
18.
[Therapy goals, change of goals and goal attainment in the process of psychoanalytically oriented and behavior long-term therapy--a comparative study from the private practices of insurance-registered psychotherapists]. / Therapieziele, Zieländerungen und Zielerreichung im Verlauf psychoanalytisch orientierter und verhaltenstherapeutischer Langzeittherapie--Eine vergleichende Untersuchung aus der Praxis niedergelassener Psychotherapeuten.
Psychother Psychosom Med Psychol
; 53(3-4): 163-70, 2003.
Artigo
em Alemão
| MEDLINE | ID: mdl-12649760