Detalhe da pesquisa
1.
cART Restores Transient Responsiveness to IFN Type 1 in HIV-Infected Humanized Mice.
J Virol
; 96(21): e0082722, 2022 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36250708
2.
PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis.
J Biol Chem
; 295(3): 868-882, 2020 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31819009
3.
Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication.
PLoS Pathog
; 14(8): e1007246, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30142226
4.
Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation.
Diabetologia
; 59(9): 2005-12, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27272237
5.
PASylated Coversin, a C5-Specific Complement Inhibitor with Extended Pharmacokinetics, Shows Enhanced Anti-Hemolytic Activity in Vitro.
Bioconjug Chem
; 27(10): 2359-2371, 2016 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27598771
6.
Enhanced in vivo efficacy of a type I interferon superagonist with extended plasma half-life in a mouse model of multiple sclerosis.
J Biol Chem
; 289(42): 29014-29, 2014 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25193661
7.
PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy.
Mol Pharm
; 12(5): 1431-42, 2015 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25811325
8.
Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats.
Toxicol Appl Pharmacol
; 263(3): 352-9, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22820422
9.
Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM.
Sci Rep
; 12(1): 18269, 2022 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36310334
10.
Hsp70 in Liquid Biopsies-A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer.
Cancers (Basel)
; 13(15)2021 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34359606
11.
First In-Human Medical Imaging with a PASylated 89Zr-Labeled Anti-HER2 Fab-Fragment in a Patient with Metastatic Breast Cancer.
Nucl Med Mol Imaging
; 54(2): 114-119, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32377263
12.
PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice.
Antiviral Res
; 161: 134-143, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30439382
13.
Regeneration After Radiation- and Immune-Mediated Tissue Injury Is Not Enhanced by Type III Interferon Signaling.
Int J Radiat Oncol Biol Phys
; 103(4): 970-976, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30503785
14.
Fusion of a recombinant antibody fragment with a homo-amino-acid polymer: effects on biophysical properties and prolonged plasma half-life.
Protein Eng Des Sel
; 20(6): 273-84, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17595342
15.
A system for concomitant overexpression of four periplasmic folding catalysts to improve secretory protein production in Escherichia coli.
Protein Eng Des Sel
; 19(8): 385-90, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16720693
16.
Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lep(ob/ob) Mice.
Endocrinology
; 157(1): 233-44, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26492472
17.
Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity.
Mol Metab
; 5(10): 869-881, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27689000
18.
High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation.
MAbs
; 7(1): 96-109, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25484039
19.
Functional humanization of an anti-CD30 Fab fragment for the immunotherapy of Hodgkin's lymphoma using an in vitro evolution approach.
Protein Eng Des Sel
; 17(12): 847-60, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15708864
20.
PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins.
Protein Eng Des Sel
; 26(8): 489-501, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23754528