Detalhe da pesquisa
1.
A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues.
Proc Natl Acad Sci U S A
; 121(16): e2309211121, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593081
2.
Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase.
J Am Chem Soc
; 143(10): 3794-3807, 2021 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33496585
3.
A TRPV1-to-secretagogin regulatory axis controls pancreatic ß-cell survival by modulating protein turnover.
EMBO J
; 36(14): 2107-2125, 2017 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28637794
4.
A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
Bioorg Med Chem
; 30: 115898, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33388594
5.
A secretagogin locus of the mammalian hypothalamus controls stress hormone release.
EMBO J
; 34(1): 36-54, 2015 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25430741
6.
The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity.
Proteins
; 86(9): 912-923, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29722065
7.
Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis.
Bioorg Med Chem Lett
; 27(19): 4582-4587, 2017 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28882483
8.
Pyridoxal-phosphate dependent mycobacterial cysteine synthases: Structure, mechanism and potential as drug targets.
Biochim Biophys Acta
; 1854(9): 1175-83, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25484279
9.
Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 3): 721-31, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25760619
10.
GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.
Cereb Cortex
; 24(12): 3277-88, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23897649
11.
RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function.
Biochem J
; 457(1): 33-41, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24107184
12.
CysK2 from Mycobacterium tuberculosis is an O-phospho-L-serine-dependent S-sulfocysteine synthase.
J Bacteriol
; 196(19): 3410-20, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25022854
13.
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 3): 432-41, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23519418
14.
Discovery of novel inhibitors targeting the Mycobacterium tuberculosis O-acetylserine sulfhydrylase (CysK1) using virtual high-throughput screening.
Bioorg Med Chem Lett
; 23(5): 1182-6, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23391589
15.
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 69(Pt 1): 25-34, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23295481
16.
Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway.
ACS Chem Biol
; 18(4): 794-802, 2023 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37005433
17.
Crystal structure of NirD, the small subunit of the nitrite reductase NirbD from Mycobacterium tuberculosis at 2.0 Å resolution.
Proteins
; 80(12): 2799-803, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22965870
18.
Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens.
Eur J Med Chem
; 228: 113976, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34815129
19.
Structure of PA4019, a putative aromatic acid decarboxylase from Pseudomonas aeruginosa.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 10): 1184-8, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22102023
20.
N-Thio-ß-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis.
Cell Chem Biol
; 28(9): 1321-1332.e5, 2021 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33826941