Detalhe da pesquisa
1.
A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation.
J Pharmacol Exp Ther
; 386(1): 80-92, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37142443
2.
A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.
Nat Chem Biol
; 10(9): 760-767, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25038787
3.
Modeling the clinical phenotype of BTK inhibition in the mature murine immune system.
J Immunol
; 193(1): 185-97, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24899507
4.
Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.
J Immunol
; 191(9): 4540-50, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24068666
5.
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
Biochem J
; 444(1): 79-88, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22397330
6.
Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists.
ACS Med Chem Lett
; 14(2): 191-198, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793423
7.
Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis.
Bioorg Med Chem Lett
; 21(21): 6258-63, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21958547
8.
Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Bioorg Med Chem Lett
; 20(2): 576-80, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20005097
9.
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
ACS Med Chem Lett
; 10(1): 80-85, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655951
10.
Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition.
Bioorg Med Chem Lett
; 18(14): 3856-9, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18595689
11.
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
J Med Chem
; 61(23): 10415-10439, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30130103
12.
Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.
J Med Chem
; 60(6): 2562-2572, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28231433
13.
Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.
J Med Chem
; 59(1): 313-27, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26653735
14.
4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases.
J Med Chem
; 48(18): 5794-804, 2005 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16134946
15.
Structure analysis reveals the flexibility of the ADAMTS-5 active site.
Protein Sci
; 20(4): 735-44, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21370305
16.
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors.
J Biol Chem
; 284(36): 24185-91, 2009 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19586907
17.
2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases.
Bioorg Med Chem Lett
; 17(12): 3349-53, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17434304
18.
Inhibition of cytochrome P450 3A4 by a pyrimidineimidazole: Evidence for complex heme interactions.
Chem Res Toxicol
; 19(12): 1650-9, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17173379