Detalhe da pesquisa
1.
Toxins in Botanical Drugs and Plant-derived Food and Feed - from Science to Regulation: A Workshop Review.
Planta Med
; 90(3): 219-242, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38198805
2.
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls.
Regul Toxicol Pharmacol
; 146: 105525, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37972849
3.
Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery.
Arch Toxicol
; 97(5): 1413-1428, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36928417
4.
OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects.
Arch Toxicol
; 97(12): 3259-3271, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37676300
5.
Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment-A Workshop Report.
Planta Med
; 88(2): 98-117, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-34715696
6.
Metabolic Pattern of Hepatotoxic Pyrrolizidine Alkaloids in Liver Cells.
Chem Res Toxicol
; 34(4): 1101-1113, 2021 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33719395
7.
In vitro biotransformation of pyrrolizidine alkaloids in different species: part II-identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids.
Arch Toxicol
; 94(11): 3759-3774, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32880719
8.
Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells.
Arch Toxicol
; 94(12): 4159-4172, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32910235
9.
Correction to: Lack of adverse effects in subchronic and chronic toxicity/carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats.
Arch Toxicol
; 94(5): 1779-1781, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32328701
10.
Lack of adverse effects in subchronic and chronic toxicity/carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats.
Arch Toxicol
; 93(4): 1095-1139, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30756133
11.
In vitro biotransformation of pyrrolizidine alkaloids in different species. Part I: Microsomal degradation.
Arch Toxicol
; 92(3): 1089-1097, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-29143854
12.
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.
Nature
; 478(7368): 197-203, 2011 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21976023
13.
Comparative investigation of the mutagenicity of propenylic and allylic asarone isomers in the Ames fluctuation assay.
Mutagenesis
; 31(4): 443-51, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26895844
14.
Hepatic metabolism of carcinogenic ß-asarone.
Chem Res Toxicol
; 28(9): 1760-73, 2015 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26273788
15.
Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells.
Chem Res Toxicol
; 28(4): 641-50, 2015 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25654323
16.
Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2.
Carcinogenesis
; 35(4): 935-41, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24318996
17.
Generalized workflow for generating highly predictive in silico off-target activity models.
J Chem Inf Model
; 54(9): 2411-22, 2014 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25137615
18.
Editorial.
Regul Toxicol Pharmacol
; 101: A1-A2, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30642615
19.
Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food.
EFSA J
; 22(3): e8640, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38476320
20.
Guidance for the assessment of detoxification processes in feed.
EFSA J
; 22(1): e8528, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38205503