Detalhe da pesquisa
1.
Oxygen-insensitive nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate.
Proteins
; 91(5): 585-592, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36443029
2.
Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci
; 24(6)2023 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36983061
3.
The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
Biochem J
; 478(13): 2601-2617, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34142705
4.
Long-term proliferation of functional human NK cells, with conversion of CD56(dim) NK cells to a CD56 (bright) phenotype, induced by carcinoma cells co-expressing 4-1BBL and IL-12.
Cancer Immunol Immunother
; 61(5): 615-28, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22021067
5.
The 3D-structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism.
FEBS Lett
; 596(18): 2425-2440, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35648111
6.
Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.
Bioorg Med Chem Lett
; 21(13): 3986-91, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21620697
7.
Minimal RB-responsive E1A promoter modification to attain potency, selectivity, and transgene-arming capacity in oncolytic adenoviruses.
Mol Ther
; 18(11): 1960-71, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20808288
8.
CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus.
Mol Cancer
; 9: 52, 2010 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20211016
9.
A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984].
Mol Ther
; 17(7): 1292-9, 2009 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19367257
10.
Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.
Biochemistry
; 48(32): 7665-72, 2009 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19580253
11.
4-1BBL costimulation retrieves CD28 expression in activated T cells.
Cell Immunol
; 256(1-2): 39-46, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217084
12.
Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.
J Mol Biol
; 368(2): 481-92, 2007 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350040
13.
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
J Med Chem
; 49(14): 4333-43, 2006 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16821793
14.
Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.
Cancer Res
; 63(17): 5532-7, 2003 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14500391
15.
Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer.
J Clin Oncol
; 22(9): 1546-52, 2004 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15051757
16.
Human Leukocyte Antigen (HLA) A*1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma.
Cancer Immunol Res
; 3(10): 1138-47, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25711537
17.
Adenovirus-mediated expression of dominant negative fibroblast growth factor (FGF) receptor 1 in thyroid cells blocks FGF effects and reduces goitrogenesis in mice.
J Clin Endocrinol Metab
; 88(9): 4472-80, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12970326
18.
Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy.
J Med Chem
; 46(23): 4818-21, 2003 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-14584930
19.
Synergistic anti-tumor effects of nitroreductase mutants and p53.
J Cancer Res Ther
; 10(3): 665-70, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25313757
20.
Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.
Biochem Pharmacol
; 79(2): 102-11, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19665450