Detalhe da pesquisa
1.
Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.
Mol Cell
; 83(12): 2020-2034.e6, 2023 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37295429
2.
Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression.
Neurobiol Dis
; 152: 105289, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33577922
3.
Revisiting the complex architecture of ALS in Turkey: Expanding genotypes, shared phenotypes, molecular networks, and a public variant database.
Hum Mutat
; 41(8): e7-e45, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32579787
4.
Mid-Gestation lethality of Atxn2l-Ablated Mice.
Int J Mol Sci
; 21(14)2020 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32698485
5.
Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule-Purkinje Neuron Synaptic Strength.
Int J Mol Sci
; 21(18)2020 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32932600
6.
Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation.
Neurobiol Dis
; 132: 104559, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31376479
7.
SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes.
Int J Mol Sci
; 20(13)2019 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31277379
8.
In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.
Int J Mol Sci
; 20(23)2019 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31766565
9.
Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations.
Mol Cell Proteomics
; 15(5): 1728-39, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26850065
10.
Elevated Global DNA Methylation Is Not Exclusive to Amyotrophic Lateral Sclerosis and Is Also Observed in Spinocerebellar Ataxia Types 1 and 2.
Neurodegener Dis
; 18(1): 38-48, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29428949
11.
Quantitative Global Proteomics of Yeast PBP1 Deletion Mutants and Their Stress Responses Identifies Glucose Metabolism, Mitochondrial, and Stress Granule Changes.
J Proteome Res
; 16(2): 504-515, 2017 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27966978
12.
Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels.
Neurobiol Dis
; 96: 115-126, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27597528
13.
TR-FRET-Based Immunoassay to Measure Ataxin-2 as a Target Engagement Marker in Spinocerebellar Ataxia Type 2.
Mol Neurobiol
; 60(6): 3553-3567, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36894829
14.
Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence.
Cells
; 9(10)2020 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33023155
15.
Efficient Prevention of Neurodegenerative Diseases by Depletion of Starvation Response Factor Ataxin-2.
Trends Neurosci
; 40(8): 507-516, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28684172
16.
Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
PLoS One
; 10(3): e0121089, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25790475
17.
The distinct genetic pattern of ALS in Turkey and novel mutations.
Neurobiol Aging
; 36(4): 1764.e9-1764.e18, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25681989